A new approach for quantifying furanodiene and curzerene: a case study on the essential oils of Eugenia uniflora L., Myrtaceae (pitangueira) leaves

Chang, Roberto; Morais, Sérgio Antônio Lemos de; Napolitano, Danielle R.; Duarte, Karina C.; Guzman, Valeska B.; Nascimento, Evandro A.

doi:10.1590/s0102-695x2011005000042

Cited by 19 publications

(6 citation statements)

References 22 publications

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“…Despite the prevalence of sesquiterpenes, the species has different chemotypes, with different major constituents being observed in different studies. The specimen analyzed in this study had curzerene as the major constituent, which again corroborated previous reported findings [32, 34]. According to Adio [35], germacrone is a heat-sensitive compound that may degrade to trans - β -elemenone during GC analysis.…”

Section: Discussionsupporting

confidence: 90%

Eugenia unifloraL. Essential Oil as a Potential Anti-LeishmaniaAgent: Effects onLeishmania amazonensisand Possible Mechanisms of Action

Rodrigues

Amorim

Oliveira

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Eugenia uniflora L. is a member of the Myrtaceae family and is commonly known as Brazilian cherry tree. In this study, we evaluated the chemical composition of Eugenia uniflora L. essential oil (EuEO) by using gas chromatography-mass spectrometry (GC-MS) and assessed its anti-Leishmania activity. We also explored the potential mechanisms of action and cytotoxicity of EuEO. Thirty-two compounds were identified, which constituted 92.65% of the total oil composition. The most abundant components were sesquiterpenes (91.92%), with curzerene (47.3%), γ-elemene (14.25%), and trans-β-elemenone (10.4%) being the major constituents. The bioactivity shown by EuEO against promastigotes (IC50, 3.04 μg·mL−1) and amastigotes (IC50, 1.92 μg·mL−1) suggested significant anti-Leishmania activity. In the cytotoxicity determination, EuEO was 20 times more toxic to amastigotes than to macrophages. Hemolytic activity was 63.22% at the highest concentration tested (400 μg·mL−1); however, there appeared to be no toxicity at 50 μg·mL−1. While the data show that EuEO activity is not mediated by nitric oxide production, they do suggest that macrophage activation may be involved in EuEO anti-Leishmania activity, as evidenced by increases in both the phagocytic capacity and the lysosomal activity. More studies are needed to determine in vivo activity as well as additional mechanisms of the anti-Leishmania activity.

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Section: Discussionsupporting

confidence: 90%

Eugenia unifloraL. Essential Oil as a Potential Anti-LeishmaniaAgent: Effects onLeishmania amazonensisand Possible Mechanisms of Action

Rodrigues

Amorim

Oliveira

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…A total of 78 compounds were identified in the essential oil samples (Table SIV -Supplementary Material), with an average of 67.26% of the identified compounds present in the genotypes. Most of the constituents were oxygenated sesquiterpenes (Table I), corroborating with findings described by other authors (Costa et al 2009, Gallucci et al 2010, Chang et al 2011, Rodrigues et al 2013.…”

Section: Essential Oil Yield and Compositionsupporting

confidence: 91%

Chemical variability of essential oils of Eugenia uniflora L. genotypes and their antioxidant activity.

Cipriano

Maia

Deschamps

2021

An. Acad. Bras. Ciênc.

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“…[ 10 ], E. brasiliensis Lam. [ 11 ], and E. uniflora L. [ 12 , 13 , 14 ]. Sesquiterpenes (hydrocarbon and oxygenated derivatives) were found as the main class of volatile constituents possessing antibacterial, antifungal, anti-inflammatory, and cytotoxic activities [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Biological Evaluation of Essential Oils from Two Species of Myrtaceae — Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel

et al. 2011

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The chemical composition and antimicrobial activity of essential oils obtained from leaves of two Myrtaceae species–Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel–were determined. Analysis by GC/MS as well as determination of Kovatz indexes indicated atractylone (26.78%) and curzerene (17.96%) as major constituents of E. uniflora oil and α-cadinol (19.15%), apiole (11.15%) and cubenol (5.43%) as main components in P. trunciflora oil. Both essential oils were tested for antimicrobial activity against yeasts and bacteria. E. uniflora and P. trunciflora essential oils were active towards two Gram-positive bacteria, Streptococcus equi and Staphylococcus epidermis. In addition, biological activity of both essential oils was detected for pathogenic yeasts of the genus Candida and Cryptococcus. E. uniflora was active towards all yeast tested and exhibited interesting minimal inhibitory concentrations (0.11 to 3.75 mg/mL) across a broad spectrum of activity.

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A new approach for quantifying furanodiene and curzerene: a case study on the essential oils of Eugenia uniflora L., Myrtaceae (pitangueira) leaves

Cited by 19 publications

References 22 publications

Eugenia unifloraL. Essential Oil as a Potential Anti-LeishmaniaAgent: Effects onLeishmania amazonensisand Possible Mechanisms of Action

Eugenia unifloraL. Essential Oil as a Potential Anti-LeishmaniaAgent: Effects onLeishmania amazonensisand Possible Mechanisms of Action

Chemical variability of essential oils of Eugenia uniflora L. genotypes and their antioxidant activity.

Chemical and Biological Evaluation of Essential Oils from Two Species of Myrtaceae — Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel

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