Anxiolytic effects of Dolichandrone falcata Seem., Bignoniaceae, stem-bark in elevated plus maze and marble burying test on mice

Badgujar, Vishal Bhagwan; Surana, Sanjay J.

doi:10.1590/s0102-695x2010005000028

Cited by 9 publications

(9 citation statements)

References 30 publications

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“…As we alluded to earlier, the MBT can be carried out with marbles spaced evenly throughout the entire arena (Badgujar & Surana, 2010;Bruins Slot et al, 2008;Kinsey et al, 2011) or placed in one section of the arena only (Llaneza & Frye, 2009;Nicolas et al, 2006;Njung'e & Handley, 1991b;Savy et al, 2015;Schneider & Popik, 2007;Thomas et al, 2009). A core concept of the MBT when applied as a measure of anxiety is that animals unconditioned to the testing paradigm may experience neophobia-related anxiety when confronted with marbles for the first time, thereby invoking either active burying or passive avoidance behavior (Bruins Slot et al, 2008;Kinsey et al, 2011).…”

Section: Zone Configuration-a Question Of Choicementioning

confidence: 99%

“…It is perhaps with respect to the arenas used for studies relating to mouse burying behavior that the greatest variation is observed; in some cases, the arenas employed have been of similar dimensions, or even larger than, those employed in rat studies. These sizees range from 23 × 17 × 14 cm (25 marbles; Broekkamp et al, 1986) and 38 × 32 × 28 cm (25 marbles; Casarotto et al, 2010) to 45 × 60 × 25 cm (24 marbles; Badgujar & Surana, 2010). Arena size is important because the Bdensity^of marbles spread across the bedding material surface, depending on the number of marbles used, would differ between smaller and larger arenas.…”

Section: Arena Sizementioning

confidence: 99%

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A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

Brouwer

Fick

Harvey

et al. 2018

Cogn Affect Behav Neurosci

101

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Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety-and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds variably to a range of pharmacological interventions, and little consensus exists regarding specific methodologies for its execution. Regardless, the test is widely applied to investigate the effects of pharmacological, genetic, and behavioral manipulations on purported behaviors related to the said neuropsychiatric constructs. Therefore, in the present review we attempt to expound the collective translational significance of the MBT. We do this by (1) reviewing burying behavior as a natural behavioral phenotype, (2) highlighting key aspects of anxiety and obsessive-compulsive disorder from a translational perspective, (3) reviewing the history and proof of concept of the MBT, (4) critically appraising potential methodological confounds in execution of the MBT, and (5) dissecting responses of the MBT to various pharmacological interventions. We conclude by underlining that the collective translational value of the MBT will be strengthened by contextually valid experimental designs and objective reporting of data.

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Section: Zone Configuration-a Question Of Choicementioning

confidence: 99%

Section: Arena Sizementioning

confidence: 99%

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

Brouwer

Fick

Harvey

et al. 2018

Cogn Affect Behav Neurosci

101

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“…A desordem da ansiedade é considerada a doença mental mais comum em todo o mundo, sendo o diagnóstico psiquiátrico mais corrente em todo o globo, afligindo entre 10-30% da população (BADGUJAR;SURANA, 2010;NETTO et al, 2009).…”

Section: Resultsunclassified

“…A atividade ansiolítica dos BZD se deve a sua ligação com receptores próprios (receptores BZD ou ômega) localizados no complexo receptor BZD/receptor GABAA/canal de cloro, facilitando a ação do GABA que é um importante e abundante neurotransmissor inibitório no sistema nervoso dos mamíferos, possibilitando assim, a hiperpolarização celular pelo aumento do influxo de Cl -, ocasionando efeitos inibitórios no sistema nervoso (ANDREATINI et al, 2001, ROSENBAUM, 2005. No entanto, embora os benzodiazepínicos apresentem conhecidos benefícios, seus efeitos colaterais são proeminentes, incluindo sedação, amnésia anterógrada, prejuízos de cognição e funções motoras hábeis, além de provocarem tolerância e dependência (BADGUJAR; SURANA, 2010;BALDESSARINI, 2001;STAHL, 2000).…”

Section: Tratamento Farmacológico Para a Ansiedadeunclassified

Ansiedade: aspectos gerais e tratamento com enfoque nas plantas com potencial ansiolítico

Sousa¹,

Oliveira²,

Calou³

2018

REVINTER

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ResumoEstima-se que 10-30% da população mundial sofra de ansiedade. Essa doença se manifesta por sensações de mal-estar psíquico, traduzidos por uma variedade de perturbações somáticas relacionadas à hiperatividade autonômica. Neste contexto, o objetivo deste trabalho foi realizar uma revisão bibliográfica sobre os aspectos mais relevantes da ansiedade, dos seus tratamentos e das perspectivas de abordagens terapêuticas advindas das plantas medicinais. A indústria farmacêutica dispõe de um grande arsenal terapêutico para a ansiedade, não obstante, sua maioria é constituída por fármacos que atuam de forma poderosa sobre o Sistema Nervoso Central, gerando inúmeros efeitos adversos em seus usuários. Dessa forma, a busca por alternativas mais seguras e efetivas encontra nas plantas medicinais uma fonte promissora, sendo grande a variedade de plantas usadas com esse propósito, onde a maioria delas já passou por testes pré-clínicos, no entanto, estes devem ser complementados com testes clínicos a fim de atestar a segurança e a eficácia das mesmas. Foi percebido que a maioria das ervas medicinais devidamente testadas podem servir como alternativas aos ansiolíticos tradicionais em pacientes que não conseguem adesão à terapia convencional, entretanto, merecem destaque a Piper methysticum G. Forster e as plantas do genêro Passiflora, sendo essas bastante utilizadas e de eficácia comprovada, logo, a bioprospecção molecular objetivando a descoberta de novas drogas ansiolíticas tem ganhado impulso uma vez que a busca por terapias alternativas e/ou complementares está em franca ascensão por aqueles que padecem de desordens do humor e de ansiedade. Palavras-chave: Plantas medicinais. Propriedades ansiolíticas. Testes da atividade ansiolítica. Anxiety: general aspects and treatment with focus on plants with anxiolytic potential AbstractIt is estimated that 10-30% of the world population suffering from anxiety. This disease cause feelings of psychic malaise, translated by a variety of somatic disorders related to autonomic hyperactivity. In this context, the aim of this study was to perform a literature review of the most relevant aspects of anxiety, treatments and the prospects for therapeutic approaches arising from medicinal plants. There many drugs aimed at treating anxiety, however, are mostly

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“…In search of new therapeutic agents for treating neurological disorders, research on medicinal plants is being progressed continuously demonstrating the pharmacological effectiveness of a variety of plant species using various animal models [10]. A number of plants have been investigated for their anxiolytic activity: Cardiospermum halicacabum [9], Zanthoxylum budrunga [11], Dolichandrone falcate [12], Cissus quadrangularis [13], Pulsatilla nigaricus [14], Cassia occidentalis [8] and Byrsocarpus coccineus [15] have been already reported.…”

Section: Introductionmentioning

confidence: 99%

Experimental Evaluation of Antidepressant and Antianxiety Activities of Aqueous Leaf Extracts of Senna Alata (L.) Roxb. Using in Vitro Animal Models

Pamulaparthi

Prathap

Banala

et al. 2016

Int J Curr Pharm Sci

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Objective: In the present investigation antidepressant and antianxiety activities of aqueous leaf extracts of Senna alata (200 mg/Kg) were carried out to establish the species as a potent natural antidepressant and anxiolytic drug. Methods:Antidepressant activity was carried out using forced swim test and tail suspension test. In both these tests, the animals were subjected to external stress that results in alteration of the behavior of animal due to fear.The antianxiety activity of aqueous leaf extracts of S. alata has been studied by the elevated plus-maze test in rats. The mean number of entries and the time spent in the open arm after 45 min of the administration of test drug was noted to determine the antianxiety effect of the test drug. Results:For antidepressant activity administration of test drug (200 mg/Kg) showed a significant decrease in the time spent by the animal in state of depression in both the assays which clearly indicates that the aqueous leaf extracts of S. alata exhibited a strong antidepressant activity similar to that of the control drug (Imipramine).In the antianxiety activity, administration of aqueous leaf extract (200 mg/Kg) of S. alata significantly increased the mean number of entries (2.25±0.98) in the open arm and the time spent in open arm (2.23±0.04) compared to the control group. The activity of the extract was slightly greater than standard drug Diazepam. Conclusion:From the above-presented results, it can be concluded that administration of Senna alata aqueous leaf extracts (200 mg/Kg) showed a considerable decrease in both antidepressant and antianxiety activities in all the test animals and can be used in the replacement of commercially available synthetic drugs in the near future.

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Anxiolytic effects of Dolichandrone falcata Seem., Bignoniaceae, stem-bark in elevated plus maze and marble burying test on mice

Cited by 9 publications

References 30 publications

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

Ansiedade: aspectos gerais e tratamento com enfoque nas plantas com potencial ansiolítico

Experimental Evaluation of Antidepressant and Antianxiety Activities of Aqueous Leaf Extracts of Senna Alata (L.) Roxb. Using in Vitro Animal Models

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