Isolamento, identificação e avaliação da atividade antileucêmica de alcaloides indólicos monoterpênicos de Tabernaemontana salzmannii (A. DC.), Apocynaceae

Figueiredo, Elaine Rodrigues; Vieira, Ivo José Curcino; Souza, Jucimar Jorgeane de; Braz-Filho, Raimundo; Mathias, Lêda; Kanashiro, Milton; Côrtes, Fernanda H.

doi:10.1590/s0102-695x2010005000019

Cited by 14 publications

(8 citation statements)

References 10 publications

(9 reference statements)

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“…These C-atoms are more shielded than in the normal series. Olivacine ( 8 , 5,0 mg) was isolated from the root bark through precipitation of the root bark EtOH extract acidic fraction (RBEEAF) and exhibited 1 H and 13 C-NMR data consistent with those found in the literature [35].…”

Section: Resultssupporting

confidence: 72%

Chemical Composition of Aspidosperma ulei Markgr. and Antiplasmodial Activity of Selected Indole Alkaloids

et al. 2013

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Abstract:A new indole alkaloid, 12-hydroxy-N-acetyl-21(N)-dehydroplumeran-18-oic acid (13), and 11 known indole alkaloids: 3,4,5,6-tetradehydro-β-yohimbine (3), 19(E)-hunteracine (4), β-yohimbine (5), yohimbine (6), 19,20-dehydro-17-α-yohimbine (7), uleine (10), 20-epi-dasycarpidone (11), olivacine (8), 20-epi-N-nor-dasycarpidone (14), N-demethyluleine (15) and 20(E)-nor-subincanadine E (12) and a boonein δ-lactone 9, ursolic acid (1) and 1D,1O-methyl-chiro-inositol (2) were isolated from the EtOH extracts of different parts of Aspidosperma ulei Markgr. (Apocynaceae). Identification and structural elucidation were based on IR, MS, 6282Plasmodium falciparum. IC 50 values of 14.0 (39.9), 4.5 (16.7) and 14.5 (54.3) μg/mL (μM) were determined for 3, 11 and 12, respectively. Inhibitory activity of 3, 4, 11, 12 and 13 was evaluated against NIH3T3 murine fibroblasts. None of these compounds exhibited toxicity to fibroblasts (IC 50 > 50 μg/mL). Of the five compounds screened for in vitro antiplasmodial activity, only 11 was active.

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Section: Resultssupporting

confidence: 72%

Chemical Composition of Aspidosperma ulei Markgr. and Antiplasmodial Activity of Selected Indole Alkaloids

et al. 2013

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“…Na abordagem fitoquímica, apresentaram resultados positivos na identificação de alcaloides totais das cascas do caule de P. cuspidata, não sendo realizado teste para as classes específicas deste metabólito. Esse metabólito secundário tem diversas propriedades biológicas, entre elas estão antibacteriana, antifúngica, antiplasmódica (SILVA et al, 2007;HENRIQUE;NUNOMURA;POHLIT, 2010), antitumoral (FIGUEIREDO, et al 2010), a presença desta classe de composto justifica, em parte, o uso pela medicina tradicional do Amapá e Guiana Francesa.…”

Section: Resultsunclassified

Estudo Fitoquímico, Toxicidade em Artemia salina Leach e Atividade Antibacteriana de Pseudoxandra cuspidata Maas

Hyacienth¹,

Almeida²

2015

Biota Amazônia

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RESUMO: A Pseudoxandra cuspidata Maas (Annonaceae Juss.), conhecida como Lamuci, é uma árvore de médio porte. Esta planta é empregada no Amapá para o tratamento de micoses superficiais e na Guiana Francesa é utilizada como antimalárico. O presente trabalho avaliou o perfil fitoquímico de P. cuspidata, toxicidade (ensaio de letalidade com Artemia salina Leach) e a atividade antibiótica do extrato pelo método de Kirby-Bauer modificado. Os resultados demonstraram que o extrato bruto etanólico apresenta média toxicidade (CL = 605, 92 mg/mL), além de ter a presença de alcaloides, compostos fenólicos e ácidos 50 orgânicos, sendo o primeiro o possível responsável por essa toxicidade e o último sendo responsável pela provável atividade antifúngica; porém no teste antibacteriano não houve inibição frente às cepas de Staphylococcus aureus, Klebsiella pneumoniae e Escherichia coli nas concentrações testadas.

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“…The results of the study revealed possible cytotoxicity (LC 50 = 1 µg/mL) in comparison to the positive control, vincristine sulphate (LC 50 = 0.3 µg/mL) [ 95 ]. Figueiredo et al [ 67 ] reported the cytotoxicity of T. salzmannii root and leaf extracts on human leukemia cells (THP-1). In this study, nine alkaloids were isolated; however, only two alkaloids, isovoacangine and voacangine ( Table 1 ), displayed extensive cancer cell death, with an IC 50 of 52.11 and 61.40 µM, respectively [ 67 ].…”

Section: Major Bioactive Components and Biological Activities Of mentioning

confidence: 99%

Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae)

Naidoo

Dewir

et al. 2021

Plants

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Several species belonging to the genus Tabernaemontana have been well researched and utilized for their wide-ranging biological activities. A few of the most prominent species include Tabernaemontana divaricata, Tabernaemontana catharinensis, Tabernaemontana crassa, and Tabernaemontana elegans. These species and many others within the genus often display pharmacological importance, which is habitually related to their chemical constituents. The secondary metabolites within the genus have demonstrated huge medicinal potential for the treatment of infections, pain, injuries, and various diseases. Regardless of the indispensable reports and properties displayed by Tabernaemontana spp., there remains a wide variety of plants that are yet to be considered or examined. Thus, an additional inclusive study on species within this genus is essential. The current review aimed to extensively analyze, collate, and describe an updated report of the current literature related to the major alkaloidal components and biological activities of species within the genus Tabernaemontana.

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Isolamento, identificação e avaliação da atividade antileucêmica de alcaloides indólicos monoterpênicos de Tabernaemontana salzmannii (A. DC.), Apocynaceae

Cited by 14 publications

References 10 publications

Chemical Composition of Aspidosperma ulei Markgr. and Antiplasmodial Activity of Selected Indole Alkaloids

Chemical Composition of Aspidosperma ulei Markgr. and Antiplasmodial Activity of Selected Indole Alkaloids

Estudo Fitoquímico, Toxicidade em Artemia salina Leach e Atividade Antibacteriana de Pseudoxandra cuspidata Maas

Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae)

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