Anticonvulsant effect of the ethanol extract of Caesalpiniapulcherrima (L.) Sw., Fabaceae, leaves

Kumar, Dinesh; Singh, Jasbir; Baghotia, Anupama; Kumar, Sunil

doi:10.1590/s0102-695x2010005000014

Cited by 12 publications

(9 citation statements)

References 16 publications

(13 reference statements)

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“…in mice: ethanol extracts of leaves of Casimiroa edulis [ 105 ] and Cnidoscolus chayamansa [ 106 ], ethanol extracts of aerial parts of Moussonia deppeana [ 107 ], Equisetum hyemale [ 93 ], and Ruta chalepensis [ 108 ], as well as methanol extracts of leaves of Chenopodium ambrosioides [ 109 ] and Rauvolfia tetraphylla [ 110 ]. The same pattern was also shown in aqueous extract of Cuphea aequipetala aerial parts [ 111 ], ethanol extract of Plumeria rubra flowers [ 112 ], aqueous extract of Larrea divaricata leaves [ 113 ], ethanol extract of Caesalpinia pulcherrima leaves and bark [ 114 , 115 ]. aqueous extract of Euphorbia prostrata whole plant [ 116 ], aqueous-methanol extract of Ceiba pentandra leaves [ 117 ], petroleum ether, chloroform, and methanol extracts of Gelsemium sempervirens roots [ 118 ], acetone extract of Capsicum annum fruits [ 119 ], and aqueous and ethanol extract of Scoparia dulcis leaves and whole plant [ 120 , 121 ].…”

Section: Toxicologysupporting

confidence: 58%

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The consumption of medicinal plants has notably increased over the past two decades. People consider herbal products as safe because of their natural origin, without taking into consideration whether these plants contain a toxic principle. This represents a serious health problem. A bibliographic search was carried out using published scientific material on native plants from Mexico, Central America, and the Caribbean, which describe the ethnobotanical and toxicological information of medicinal plants empirically considered to be toxic. A total of 216 medicinal plants belonging to 77 families have been reported as toxic. Of these plants, 76 had been studied, and 140 plants lacked studies regarding their toxicological effects. The toxicity of 16 plants species has been reported in clinical cases, particularly in children. From these plants, deaths have been reported with the consumption of Chenopodium ambrosioides, Argemone mexicana, and Thevetia peruviana. In most of the cases, the principle of the plant responsible for the toxicity is unknown. There is limited information about the toxicity of medicinal plants used in Mexico, Central America, and the Caribbean. More toxicological studies are necessary to contribute information about the safe use of the medicinal plants cited in this review.

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Section: Toxicologysupporting

confidence: 58%

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Epilepsy may be associated with factors such as trauma, oxygen deprivation, tumors and infection 3 . There are many antiepileptic drugs presently in clinical use like phenytoin, carbamazepine, Ethosuximide, phenobarbitone and clonazepam 2,4 . The current therapy of epilepsy with modern antiepileptic drugs is associated with side effects , dose related and chronic toxicity and teratogenicity 5 , and around 30% of the patients continue to have seizures with current antiepileptic drugs 3,6 .…”

Section: Introductionmentioning

confidence: 99%

“…Medicinal herbs had been used traditionally in the treatment of epilepsy as one alternative to synthetic drugs to avoid their side effects 4,7 . Achillea fragrantissima is a medicinal shrub plant that belongs to the Asteraceae family (formerly Compositae) 8 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Mudawi

El-wahab

Yassin

et al. 2017

AJPRHC

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In Kingdom of Saudi Arabia Achillea fragrantissima is a fragrant, perennial herb has long been used medicinally for its analgesic properties among Rafha residents. The present study concluded that Achillea fragrantissima (Gaisoom) possess a potent anticonvulsant activity against PTZ induced seizures which may be due to GABAA agonistic activity and /or antioxidant activity. The results of the current study showed that the ethanolic extract of Gaisoom at doses of 300 mg/kg and 600 mg/kg has anticonvulsant activity in pentylenetetrazole and maximum electroshock induced seizures models on mice. The Hexane extract have protected the mice against pentylenetetrazole -induced seizures with 100% protection rate and 100% animal survival similar to the anticonvulsant drug phenobarbital. HPLC-DAD fingerprints of different fractions were also carried out to find the pharmacological active compound. The studies are in progress to isolate the compounds by HPLC technique. Supplementary studies are required to explain the exact mechanism of action by which Gaisoom act as an anticonvulsant agent.

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“…Nearly 40 million people all over the world are affected 5 . Prevalence rate of epilepsy is about 5.59 per 1000 population in India 6 . Currently, many drugs are available for treating this disorder, but these drugs have draw backs like teratogenicity and other dose-related side effects.…”

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confidence: 99%

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2018

IJPSR

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To evaluate the anticonvulsant property of Zingiber officinale as well as its interaction with conventional anticonvulsant drug using Maximal electroshock seizures (MES) model and to evaluate possible mechanism involved in its action. Method: The present study was done after getting ethical clearance. The rhizomes of ginger were authenticated and extraction of dried rhizomes was done by using Soxhlet apparatus to obtain its ethanolic extract. Animals were divided into 4 groups using Phenytoin (25 mg/kg) as the standard drug. The alcoholic extract of Zingiber officinale was given at the doses of 200 mg/kg and 100 mg/kg. The test samples will be given one hour prior to induction of convulsions. Results: In MES model, the alcoholic extract of Zingiber officinale at the doses of 200 mg/kg and 100 mg/kg p.o significantly reduced the duration of tonic hind limb extension (THLE) in mice (P<0.05) in a dose dependent manner as compared to the vehicle control. The extract at a dose of 200 mg/kg body weight is found to be effective nearly similar to that of standard drug Phenytoin. Conclusion: The ethanolic extract of Zingiber officinale showed significant anticonvulsant activity in Maximal electroshock seizures (MES) model. INTRODUCTION: Ginger, the rhizome of Zingiber officinale, is one of the commonly used species of the ginger family Zingiberaceae and is used for various foods and beverages 1. Although probably a native of Asia, Z. officinale has become naturalized in many countries and is now widely distributed throughout tropical and subtropical parts of the world. Ginger has been cultivated for thousands of years for medicinal purposes and as a spice. It is used extensively in traditional medicine to treat cold, fever, headache, nausea, and digestive problems and is also used in western herbal medical practices for the treatment of arthritis, rheumatic disorders, and muscular discomfort 2 .

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Anticonvulsant effect of the ethanol extract of Caesalpiniapulcherrima (L.) Sw., Fabaceae, leaves

Cited by 12 publications

References 16 publications

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

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