Atividade biológica de metabólitos secundários de algas marinhas do gênero Laurencia

Machado, Fernanda Lacerda da Silva; Kaiser, Carlos R.; Costa, Sônia Soares; Gestinari, Lísia Mônica de Souza; Soares, Angélica Ribeiro

doi:10.1590/s0102-695x2010000300024

Cited by 26 publications

(12 citation statements)

References 53 publications

(36 reference statements)

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“…The most active anti-HSV extracts were obtained from the species L. dendroidea, U. fasciata, C. decorticatum, S. zonale, S. cymosum, C. acicularis and P. capitatus. Red algae of the genus Laurencia are found in tropical and subtropical regions throughout the world and are an extremely rich source of secondary metabolites with diverse structural features, mainly halogenated terpenes and C15-acetogenins, with a broad spectrum of biological activity (Machado et al, 2010). The halogenated sesquiterpenes obtusol (1) and (-)-elatol (2) were identified as the major compounds of L. dendroidea.…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Soares¹,

Robaina²,

Mendes³

et al. 2012

Rev. bras. farmacogn.

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Organic extracts of 36 species of marine algae (sixteen species of Rhodophyta, eight species of Ochrophyta and twelve species of Chlorophyta) from seven locations on the Brazilian coast were evaluated for their anti-HSV-1 and anti-HSV-2 activity resistant to Acyclovir (ACV). Activity tests in crude extracts, followed by the identification of the major compounds present, were performed for all species. The chemical profiles of all crude extracts were obtained by 1 H-NMR and 13 C-NMR spectroscopy. The percentage of extracts with antiviral activity was higher for HSV-1 (86.1%) than for HSV-2 (55.5%). The green algae Ulva fasciata and Codium decorticatum both showed the highest activity (99.9%) against HSV-1, with triacylglycerols and fatty acids as the major components. The red alga Laurencia dendroidea showed good activity against HSV-1 (97.5%) and the halogenated sesquiterpenes obtusol and (-)-elatol were identified as the major components in the extract. Against HSV-2, the green alga Penicillus capitatus (Chlorophyta) and Stypopodium zonale (Ochrophyta) were the most active (96.0 and 95.8%). Atomaric acid, a meroditerpene, was identified as the major secondary metabolite in the S. zonale extract. These results reinforce the role of seaweeds as important sources of compounds with the potential to enter into the pipeline for development of new drugs against herpes simplex.

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Section: Discussionmentioning

confidence: 99%

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Soares¹,

Robaina²,

Mendes³

et al. 2012

Rev. bras. farmacogn.

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“…According to Smit, 2004 the discovery of metabolites with biological activity from algae increased substantially in the last three decades. These substances exhibit an appreciable number of distinct biological activities such as antitumor, antiviral, antifungal, insecticidal, cytotoxic, phytotoxic and antiproliferative actions (Machado et al, 2010). The majority of these compounds are terpenes and polyphenols (Blunt et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Screening of Antifungal Activities of Five Algal Crude Extracts

Musbah

Abouelkhair

Yousef

et al. 2019

Journal of Scientific Research in Science

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In the present study, four species of marine algae were collected during different seasons for one year (September 2013 to August 2014). The collected species belonged to Chlorophyta (Ulva lactuca), Phaeophyta (Sargassum denticulatum, Hormophysa triquetra) and Rhodophyta (Hypnea cornuta) in addition to one blue-green alga from freshwater (Spirulina platensis) was obtained from stock at Hydrobiology Lab, Qanater, Khayria, Qalubia, Egypt. Crude algal extracts were prepared by using different solvents (methanol, ethanol and chloroform) in addition to hot water and cold water extracts. The crude algal extracts were examined for their antifungal efficacy against oral Candida species (Candida albicans, C.tropicalis, C.krusei and C.glabrata) using agar well diffusion method. Results revealed that methanol was the best solvent suited for extraction of bioactive compounds from the tested algae. Chlorophyta (ulva lactuca) exhibited the highest antifungal effect followed by Phaeophyta, Rhodophyta and blue green algae. MIC of the most potent algal (ulva lactuca) methanol extract was 62.5 mg/ml and MFC was 125mg/ml for the same alga with all the tested oral Candida species. (comparison was made between MFC value of Ulva lactuca methanol extract with the anti chlorhexidine (0.1mg/ml)(which is a common antimicrobial agents in commercialized oral rinses). by using (PIDG) .The results shown that the Ulva lactuca methanol extract better than PIDG of chlorhexidine.

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“…According to Smit (2004) the discovery of metabolites with biological activity from algae increased substantially in the last three decades. These substances exhibit an appreciable number of distinct biological activities such as antitumoral, antiviral, antifungal, insecticidal, cytotoxic, phytotoxic, and antiproliferative actions (MACHADO et al, 2010(MACHADO et al, , 2011KLADI et al 2006;BHAKUNI;RAWAT, 2005). The majority of these compounds are terpenes and polyphenols (BLUNT et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antifungal activity of seaweed extracts

et al. 2012

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Seaweeds are subject to numerous biological interactions and sometimes to extreme abiotic conditions, so they have developed among other defense mechanisms, the ability to produce biologically active substances. Thus, these organisms produce mainly terpenes and phenols. Among others, the antifungal activity, due to its importance in human and animal health and the production of agricultural products, has been the subject of several studies. In the present work, this activity was investigated in ten seaweeds extracts, by direct bioautography assays, compared to Colletotrichum lagenarium and disk diffusion assay, compared to Aspergillus flavus. The organisms studied were: Stypopodium zonale, Laurencia dendroidea, Ascophyllum nodosum, Sargassum muticum, Pelvetia canaliculata, Fucus spiralis, Sargassum filipendula, Sargassum stenophyllum, Laminaria hyperborea and Gracilaria edulis. S. zonale, L. dendroidea, P. canaliculata, S. muticum, A. nodosum and F. spiralis extracts significantly inhibited the C. lagenarium growth, but not inhibited significantly the A. flavus growth. The presence of terpenes in all of these extracts was confirmed by thin layer chromatography whereas the presence of phenolic compounds was confirmed only in extracts of P. canaliculata, A. nodosum and S. muticum. In chemical study by column chromatography, followed by gas chromatography/mass spectrometry analysis, the terpenes neophytadiene, cartilagineol, obtusol elatol; and the ester ethyl hexadecanoate were identified in the L. dendroidea extract. This is the first report on the activity of seaweed extracts against C. lagenarium, a fungus bearing agricultural importance.Index terms: Etanolic extract, Colletotrichum lagenarium, Aspergillus flavus. RESUMOAs macroalgas marinhas, por estarem sujeitas a numerosas interações biológicas e, por vezes, a condições abióticas extremas, desenvolveram, entre outros mecanismos de defesa, a capacidade de produzir substâncias biologicamente ativas. Assim, esses organismos produzem, principalmente, terpenos e fenóis. Entre outras, a atividade antifúngica, por sua importância na saúde humana e animal e na preservação de produtos agrícolas, tem sido objeto de diversos estudos. No presente trabalho, esta atividade foi investigada em dez extratos de macroalgas marinhas, por ensaios de bioautografia direta, frente ao fungo Colletotrichum lagenarium e por ensaio de difusão em disco, frente ao Aspergillus flavus.

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Atividade biológica de metabólitos secundários de algas marinhas do gênero Laurencia

Cited by 26 publications

References 53 publications

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Screening of Antifungal Activities of Five Algal Crude Extracts

Evaluation of antifungal activity of seaweed extracts

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