Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae

Paula-Zurron, Ana Claudia B. De; Petraglia, Nilva M. M. A.; Aur, Carlos R.; Moura, Sérgio Henrique Pereira; Imamura, Paulo M.; Freitas, José Carlos de; Catanzaro-Guimarães, S. A.

doi:10.1590/s0102-695x2010000200008

Cited by 7 publications

(2 citation statements)

References 22 publications

(20 reference statements)

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“…These results indicated a probable action mechanism in ciclooxigenase II (COX-2) enzyme. Paula-Zurron et al (2010) recently related that I. imperati showed analgesic and antiedematogenic properties. Additionally, the analgesic effect can be related to the opioid system, showing central analgesic property.…”

Section: Introductionmentioning

confidence: 99%

Anti-oxidative and anti-ulcerogenic activity of Ipomoea imperati

Miyahara¹,

Imamura²,

Freitas

et al. 2011

Rev. bras. farmacogn.

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Abstract:Ipomoea imperati (Vahl) Griseb., Convolvulaceae, is used in traditional medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains and stomach problems. This work evaluates the anti-oxidative activity by ESR (Electron Spin Resonance spectroscopy) and the preventive and curative actions of I. imperati in gastric ulcer animal model. Ipomoea imperati (200 mg/kg, p.o.) prevented the formation of gastric lesions in 78% (p<0.05) when compared with the negative control tween 80. Lanzoprazole, prevented in 85% the gastric lesions formation induced by ethanol (p<0.05). Therefore, the oral administration of I. imperati one hour before the ulcerogenic agent prevented the ulcer formation, conserving the citoprotection characteristics of the gastric mucosa and assuring the integrity of gastric glands and gastric fossets. The healing activity of I. imperati (200 mg/kg, p.o.) evaluated in chronic ulcer experiments induced by the acetic acid, was 72% (p<0.05). The positive control, ranitidine, healed 78% of the gastric lesions (p<0.05). The histological analysis confirmed the recovery of the mucosal layer and the muscle mucosal layer harmed by the acetic acid. Experiments in vitro with DPPH (2.2-diphenyl-1-picrylhydrazyl) of anti-oxidative activity demonstrated that I. imperati presents an IC50 of 0.73±0.01 mg/mL.

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Section: Introductionmentioning

confidence: 99%

Anti-oxidative and anti-ulcerogenic activity of Ipomoea imperati

Miyahara¹,

Imamura²,

Freitas

et al. 2011

Rev. bras. farmacogn.

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“…Rural communities in the Maranhão State, Brazil, have used this plant for antiparasitic purposes, in tick control and diarrhea treatment in ruminants (Costa Jr, personal communication). Based on pharmacological studies, the important therapeutic potential of this species involves antinociceptive [18], anti-oxidative, anti-ulcerogenic [19], anti-spasmodic and anti-inflammatory properties [20, 21]. In the face of the reports of indications of popular use for parasitic control and the lack of experimental verification regarding at antiparasitic property of this species, the present study aims to investigate differences in the chemical composition and effectiveness of extracts of different parts of I .…”

Section: Introductionmentioning

confidence: 99%

Antiparasitic activities of hydroethanolic extracts of Ipomoea imperati (Vahl) Griseb. (Convolvulaceae)

et al. 2019

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Ipomoea imperati is widely used in tropical areas to treat several pathological conditions. The effect of this plant against parasitic species has not been investigated even being used for this purpose in the Brazilian northeastern. This study aimed to evaluate the anthelmintic and acaricide potential of a hydroethanolic extract of I. imperati leaves and stolons. I. imperati leaves and stolons were crushed and subjected to maceration in ethanol 70% (v/v), after which the solvent was removed using a rotary evaporator. The chromatographic profile of the extract was obtained by UV Spectrum high-performance liquid chromatography and compounds were identified by liquid chromatography/electrospray ionization tandem mass spectrometry. Identification of the compounds present in the extract was achieved by comparing their retention times and UV spectra with data in the literature. Anthelmintic activity was evaluated by larval exsheathment inhibition assays using Haemonchus contortus larvae and five concentrations of each extract ranging from 0.07 to 1.2 mg/mL. Acaricide activity was evaluated via larval immersion of Rhipicephalus microplus in eight concentrations of each extract ranging from 5.0 to 25.0 mg/mL. Live and dead larvae were counted after 24 hours. The median inhibitory concentration (IC50) for H. contortus larvae and the median lethal concentration (LC50) for R. microplus larvae were calculated. Twelve compounds were observed in the hydroethanolic extract of leaves, with a predominance of the aglycone form of flavonoids and tannins. This extract was effective against H. contortus larvae, presenting an average inhibitory concentration of 0.22 mg/mL, but showed no activity toward R. microplus larvae. The stolon hydroethanolic extract presented 11 compounds, with phenolic acids and glycosylated flavonoids prevailing. This extract showed low activity on R. microplus and no effect on inhibiting H. contortus larval exsheathment at the concentrations tested. This study is the first to assess the anthelmintic and acaricidal activities of I. imperati. Data reported confirm promising potential of I. imperati leaves hydroethanolic extract against H. contortus. This effect could be due to its secondary compounds presents in this extract, such as procyanidin, kaempferol, isoquercitrin and rutin.

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Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

Chen

Liu

Yang

et al. 2018

Phytotherapy Research

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Central nervous system (CNS) disorders play a major impact on individual lives and place a severe strain on health care resources. Convolvulaceae is a family comprising approximately 1,600-1,700 species grouped in 55-60 genera, and many species are reported to have an effect on CNS functions. A systematic review of the literature studies was carried out to summarize available evidences on Convolvulaceae plants with CNS efficacies. This review is based on various data sources such as Google Scholar, Web of Science, Scopus, PubMed, and Wanfang Data. A total of 200 related articles were included in this review. According to the research result, 54 Convolvulaceae species are suggested to display CNS efficacies historically, and 46 species have been evaluated for their CNS efficacies. In addition, 67 compounds from 16 Convolvulaceae species are recognized to possess CNS efficacies. Despite great progress made through pharmacology and phytochemistry studies on CNS active Convolvulaceae species, more exploratory research is needed to gain a better understanding of the CNS efficacies of this plant family.

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Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae

Cited by 7 publications

References 22 publications

Anti-oxidative and anti-ulcerogenic activity of Ipomoea imperati

Anti-oxidative and anti-ulcerogenic activity of Ipomoea imperati

Antiparasitic activities of hydroethanolic extracts of Ipomoea imperati (Vahl) Griseb. (Convolvulaceae)

Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

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