Análise morfoanatômica das partes aéreas de Wedelia paludosa DC. (Acmela brasiliensis, Sphagneticola trilobata), Asteraceae

Baccarin, Thaisa; Czepula, Alexandra Ingrid dos Santos; Ferreira, Renê A.; Lucinda-Silva, Ruth Meri

doi:10.1590/s0102-695x2009000400018

Cited by 8 publications

(6 citation statements)

References 14 publications

(11 reference statements)

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“…Sphagneticola trilobata is used popularly to treat rheumatic inflammatory diseases and fever. 1,11 Of note, rheumatic diseases such as rheumatoid arthritis are accompanied by pain. 12 As a consequence, it has been demonstrated that 1 inhibits the acetic acid-induced writhing response in mice.…”

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confidence: 99%

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confidence: 99%

“…Kaurenoic acid [ ent -kaur-16-en-19-oic acid ( 1 )] is a diterpene obtained from a number of plants and is a major compound in Sphagneticola trilobata (L.) Pruski (syn. Wedelia paludosa , Acmella brasiliensis ; Asteraceae), which is known popularly in Brazil as “arnica-do-mato”, “pseudo-arnica”, “picão-da-praia”, and “vedélia”. There is evidence that 1 exhibits its biological effects by inhibiting the inflammatory process such as in the carrageenin-induced paw edema , and TPA-induced ear edema models .…”

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Kaurenoic Acid from Sphagneticola trilobata Inhibits Inflammatory Pain: Effect on Cytokine Production and Activation of the NO–Cyclic GMP–Protein Kinase G–ATP-Sensitive Potassium Channel Signaling Pathway

et al. 2012

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Kaurenoic acid [ent-kaur-16-en-19-oic acid (1)] is a diterpene present in several plants including Sphagneticola trilobata. The only documented evidence for its antinociceptive effect is that it inhibits the writhing response induced by acetic acid in mice. Therefore, the analgesic effect of 1 in different models of pain and its mechanisms in mice were investigated further. Intraperitoneal and oral treatment with 1 dose-dependently inhibited inflammatory nociception induced by acetic acid. Oral treatment with 1 also inhibited overt nociception-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), and both phases of the formalin test. Compound 1 also inhibited acute carrageenin- and PGE(2)-induced and chronic CFA-induced inflammatory mechanical hyperalgesia. Mechanistically, 1 inhibited the production of the hyperalgesic cytokines TNF-α and IL-1β. Furthermore, the analgesic effect of 1 was inhibited by l-NAME, ODQ, KT5823, and glybenclamide treatment, demonstrating that such activity also depends on activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway, respectively. These results demonstrate that 1 exhibits an analgesic effect in a consistent manner and that its mechanisms involve the inhibition of cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.

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Kaurenoic Acid from Sphagneticola trilobata Inhibits Inflammatory Pain: Effect on Cytokine Production and Activation of the NO–Cyclic GMP–Protein Kinase G–ATP-Sensitive Potassium Channel Signaling Pathway

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“…Our research group, in addition to morpho-anatomical (Baccarin et al 2009), phytochemical, efficacy (Block et al 1998a.b;Bresciani et al 2004) and oral safety studies (B€ urger et al 2005), has developed analytical methods to control the quality of S. trilobata hydroethanolic dried extracts (Fucina et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Topical anti-inflammatory phytomedicine based onSphagneticola trilobatadried extracts

Fucina¹,

Rocha²,

Silva³

et al. 2016

Pharmaceutical Biology

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Context: The aerial parts of Sphagneticola trilobata (L.) Pruski (Asteraceae) are popularly used to treat topical inflammation, but have not been fully investigated. Objective: To identify polar compounds in S. trilobata extracts and develop a new topical phytomedicine based on the kaurenoic acid (KA) content while monitoring and demonstrating its topical anti-inflammatory activity. Materials and methods: Ethanol spray-dried extract of S. trilobata was analysed by LC-MS while the KA content from semisolid was analysed by LC-UV. The extent of ear edema induced by applying 20 lL of croton oil (2.5%), arachidonic acid (AA; 2 mg/ear) and decanoylphorbol-13-acetate (TPA; 2.5 mg/ear) in mice was used to evaluate the biological activity of the semisolids, which were applied 30 min before the phlogistic agents. Results: Eight phenylpropanoids and four oleanane-type triterpenoid saponins were identified, majority of them reported for the first time in this species, in addition to KA. The semisolid containing 1.0% of dried extract reduced the ear edema induced by croton oil [77.2 6 4.5%; ID50 ¼ 0.49 (0.28-0.87%)], TPA (81.5 6 2.4%) and AA (39.1 6 6.9%), with decreasing effect at higher KA concentrations. This was accompanied by neutrophil migration inhibition as investigated by biochemical and histological assays. Discussion and conclusion: The anti-inflammatory effects were (at least in part) due to the interference in protein kinase C (PKC) activation, AA-cascade products and neutrophil migration inhibition, demonstrating the efficacy of the folk topical usage of this plant. The results support the development of a novel topical anti-inflammatory phytomedicine properly standardized to treat inflammatory dermatological diseases. ARTICLE HISTORY

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“…There are various reported studies of synthetic compounds and natural products as potential sources of leishmanicidal activity [ 6 , 7 ]. An interesting molecule towards this aim is kaurenoic acid [ ent -kaur-16-en-19-oic acid] (KA), a diterpene obtained from various Brazilian plants [ 8 , 9 ]. This molecule has been reported as showing a wide variety of biological activities such as antiprotozoal [ 10 , 11 ], antimicrobial [ 12 ], antinociceptive [ 13 ], vasorelaxant, hypotensive [ 14 , 15 ], and anti-inflammatory [ 13 , 16 , 17 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL‐1β/cNOS/NO Pathway

Miranda

Panis²,

Silva

et al. 2015

Mediators of Inflammation

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Leishmania amazonensis (L. amazonensis) infection can cause severe local and diffuse injuries in humans, a condition clinically known as American cutaneous leishmaniasis (ACL). Currently, the therapeutic approach for ACL is based on Glucantime, which shows high toxicity and poor effectiveness. Therefore, ACL remains a neglected disease with limited options for treatment. Herein, the in vitro antiprotozoal effect and mechanisms of the diterpene kaurenoic acid [ent-kaur-16-en-19-oic acid] (KA) against L. amazonensis were investigated. KA exhibited a direct antileishmanial effect on L. amazonensis promastigotes. Importantly, KA also reduced the intracellular number of amastigote forms and percentage of infected peritoneal macrophages of BALB/c mice. Mechanistically, KA treatment reestablished the production of nitric oxide (NO) in a constitutive NO synthase- (cNOS-) dependent manner, subverting the NO-depleting escape mechanism of L. amazonensis. Furthermore, KA induced increased production of IL-1β and expression of the inflammasome-activating component NLRP12. These findings demonstrate the leishmanicidal capability of KA against L. amazonensis in macrophage culture by triggering a NLRP12/IL-1β/cNOS/NO mechanism.

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Análise morfoanatômica das partes aéreas de Wedelia paludosa DC. (Acmela brasiliensis, Sphagneticola trilobata), Asteraceae

Cited by 8 publications

References 14 publications

Kaurenoic Acid from Sphagneticola trilobata Inhibits Inflammatory Pain: Effect on Cytokine Production and Activation of the NO–Cyclic GMP–Protein Kinase G–ATP-Sensitive Potassium Channel Signaling Pathway

Kaurenoic Acid from Sphagneticola trilobata Inhibits Inflammatory Pain: Effect on Cytokine Production and Activation of the NO–Cyclic GMP–Protein Kinase G–ATP-Sensitive Potassium Channel Signaling Pathway

Topical anti-inflammatory phytomedicine based onSphagneticola trilobatadried extracts

Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL‐1β/cNOS/NO Pathway

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