Constituintes químicos das folhas de Murraya paniculata (Rutaceae)

Mesquita, Sumaia G.; Martinez, Marcela F.; Romoff, Paulete; Fávero, Oriana A.; Lieber, Sofia Rocha; Lago, João Henrique G.

doi:10.1590/s0102-695x2008000400011

Cited by 10 publications

(9 citation statements)

References 15 publications

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“…Previous phytochemical studies showed two new coumarins from M paniculata (Mesquita et al, 2008;Saied et al, 2008), the identification of dioxin and dioxin-like polychlorbiphenyls in plant tissues and contaminated soils (Jou et al, 2007). Isoflavonoids in the Rutaceae family was found in Fortunella obovats, M. paniculata and four in Citrus species (Lapcik et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and bioactivity of leaves of Murraya paniculata (L.) Jack, Rutaceae

Sharker¹,

Shahid²,

Hasanuzzaman³

2009

Rev. bras. farmacogn.

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RESUMO: "Antinociceptiva e bioatividade das folhas de Murraya paniculata (L.) Jack, Rutaceae". Os resultados dos estudos de atividade antinociceptiva e toxicológicos do extrato etanólico de Murraya paniculata (L.) Jack, Rutaceae são relatados. O extrato (nas doses de 250 e 500 mg/kg) produziu um alta atividade antinociceptiva na forma dose-dependente. O extrato também mostrou considerável toxicidade no teste de Artemia salina (DL50 = 32 µg/mL). Unitermos:Murraya paniculata, Rutaceae, contorções, analgesico, citotóxico. ABSTRACT:The results of antinociceptive and toxicological studies on the ethanol extract of the leaves of Murraya paniculata (L.) Jack, Rutaceae, are reported. The extract (250 and 500 mg/kg dosages) was found to produce a profound antinociceptive activity in a dose dependent manner. The extract showed considerable brine shrimp toxicity (LD 50 = 32 µg/mL).

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Section: Introductionmentioning

confidence: 99%

Antinociceptive and bioactivity of leaves of Murraya paniculata (L.) Jack, Rutaceae

Sharker¹,

Shahid²,

Hasanuzzaman³

2009

Rev. bras. farmacogn.

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“…Phytochemical analysis shows that M. paniculata extract contains carbohydrates, proteins, amino acids, and phenolic compounds (Gautam et al, 2012a), phytosterol and coumarins (Ito et al, 2005;Mesquita et al, 2008), alkaloids and flavonoids (Alitheen, 2012), and flavone derivatives (Lu et al, 2012). The flavone occurring, 5,7,3 0 ,4 0 -tetramethoxyflavone, is one of the major polymethoxyflavones identified in M. paniculata (Lu et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and evaluation of acute toxicological, antimicrobial and modulatory resistance of the extract ofMurraya paniculata

Menezes

Santana

Varela

et al. 2014

Pharmaceutical Biology

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Context: Murraya paniculata (Linn) JACK (Rutaceae) is used in traditional medicine in the treatment of diabetes, inflammation, and microbial disorders. Objective: This study determined the polyphenol composition and antimicrobial and acute toxicological activity of the hydroethanolic extract of M. paniculata leaves (EEMp). Materials and methods: Chemical composition was evaluated by the Folin-Ciocalteu and AlCl 3 assays and by HPLC-DAD. Antibacterial and modulatory activity was determined by the microdilution method. Toxicity was assessed with a single dose of EEMp administered orally at doses of 2000 and 5000 mg/kg body weight/day in male and female Swiss mice. Results: Total phenolic content of the EEMp samples varied from 66.5 to 396.8 mg gallic acid equivalent/g of extract and flavonoid content varied from 0.3 to 31.1 mg quercetin equivalent/g of extract. The principal component identified by HPLC-DAD assay was ellagic acid. The results of oral acute toxicity showed no mortality, changes in hematological parameters, or CNS and ANS toxicities in rats. Biochemical analysis showed a significant increase in glucose and glutamic oxaloacetic transaminase activity and reduction in triglycerides and cholesterol for 5000 and 2000 mg/kg doses, respectively, when compared with the control group. Histopathological evaluation showed no significant microscopic changes. EEMp showed essentially no antimicrobial activity, but when aminoglycosides were combined with EEMp their MIC was reduced. Conclusions: Significant effects were observed in the acute toxicity assay, but they had no clinical relevance. The results suggest that M. paniculata could be used as a source of natural products with antibacterial resistance-modifying activity, with lower toxicity.

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“…The species M. paniculata (L.) Jack, which is a tree native to India, was brought to Brazil to be used for afforestation and garden ornamentation (Mesquita et al, 2008). In tropical and subtropical regions in Asia, besides China and Indonesia, this species is considered medicinal; thus, it has been used for treating intestine disorders, rheumatism and cough (Mesquita et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus

Silva

Fernandes

Santiago

et al. 2020

Braz. J. Pharm. Sci.

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This study aims to investigate chemical composition of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits and determine their in vitro antibacterial activity. Essential oils were extracted by hydrodistillation from Murraya paniculata (L.) Jack ripe and unripe fruits collected in the Cerrado, in Rio Verde, southwestern Goiás, Brazil. They were analyzed by gas chromatography with flame ionization detector (GC-FID) and by gas chromatography-mass spectrometry (GC-MS). Sesquiterpenes, which represent the most abundant class of compounds in oils, predominated in both ripe and unripe fruits. Major constituents of essential oils extracted from ripe fruits (RF-EO) were β-caryophyllene (21.3%), α-ylangene (13.3%), germacrene-D (10.9%) and α-zingiberene (9.7%) whereas the ones of unripe fruits (UF-EO) were sesquithujene (25.0%), α-zingiberene (18.2%), germacrene-D (13.1%) and α-copaene (12.7%). In vitro antibacterial activity of essential oils was evaluated in terms of its minimum inhibitory concentration (MIC) values by the broth microdilution method in 96-well microplates. Both essential oils under investigation showed moderate anti-streptococcal activity against the following bacteria: Streptococcus mutans, S. mitis, S. sanguinis, S. sobrinus and S. salivarius. MIC values ranged between 100 and 400 µg/mL. Regarding the antimycobacterial activity, essential oils from M. paniculata (L.) Jack unripe and ripe fruits were active against Mycobacterium kansasii (MIC = 250 µg/mL), moderately active against M. tuberculosis (MIC = 500 µg/mL) and inactive against M. avium (MIC = 2000 µg/mL). This study was pioneer in revealing similar chemical profiles of both essential oils extracted from Murraya paniculata (L.) Jack unripe and ripe fruits, besides describing their in vitro anti-streptococcal and antimycobacterial activities.

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Constituintes químicos das folhas de Murraya paniculata (Rutaceae)

Cited by 10 publications

References 15 publications

Antinociceptive and bioactivity of leaves of Murraya paniculata (L.) Jack, Rutaceae

Antinociceptive and bioactivity of leaves of Murraya paniculata (L.) Jack, Rutaceae

Chemical composition and evaluation of acute toxicological, antimicrobial and modulatory resistance of the extract ofMurraya paniculata

Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus

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