Aqueous leaf extract of Averrhoa carambola L. (Oxalidaceae) reduces both the inotropic effect of BAY K 8644 on the guinea pig atrium and the calcium current on GH3cells

Vasconcelos, Carla Maria Lins de; Gondim, Antônio Nei Santana; Cruz, Jáder Santos; Mafra, Roberta Amaral; Silva, Bagnólia A.; Conde-Garcia, Eduardo Antônio

doi:10.1590/s0102-695x2008000400007

Cited by 5 publications

(3 citation statements)

References 17 publications

(18 reference statements)

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“…An alcoholic extract of the stems of A. carambola has been shown to exhibit selective activity against brain tumor cells while that of the leaves was effective against liver carcinoma cells (Tadros & Sleem, 2004). The aqueous leaf extract of A. carambola depresses atrial inotropism in the guinea pig (Vasconcelos et al, 2008). In this paper we describe the isolation of one sterol and three glycosyl fl avones from the leaves of A. carambola.…”

Section: Introductionmentioning

confidence: 97%

Chemical constituents and evaluation of the toxic and antioxidant activities of Averrhoa carambola leaves

Moresco¹,

Queiroz²,

Pizzolatti³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The liquid-liquid partitioning of a crude hydroalcoholic extract of Averrhoa carambola L., Oxalidaceae, leaves led to the isolation of a sterol and three flavone C-glycosides. From the n-hexane fraction β-sitosterol was isolated and from the ethyl acetate fraction apigenin-6-C-β-L-fucopyranoside (1) and apigenin- (3) was isolated from the n-butanol fraction. Compound 3 is new, while 1 and 2 have been previously isolated from A. carambola. The antioxidant activity was measured using the DPPH radical scavenging assay and reducing power of iron (III) to iron (II) ions. The ethyl acetate and n-butanol fractions showed the most antioxidant activity. As evaluated by ability of the sample to scavenge DPPH the IC50 values were 90.92 and 124.48 µg/ mL, respectively. In the assay of reducing power these fractions presented 135.64 and 125.12 of ascorbic acid equivalents, respectively. The antioxidant activity exhibited a significant relationship with the phenolic content (r 2 = 0.997), but a poor relationship with the flavonoids content (r 2 = 0.424). The n-hexane fraction was the only fraction to present good toxicity using A. salina with LC50 800.2 μg/mL.

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Section: Introductionmentioning

confidence: 97%

Chemical constituents and evaluation of the toxic and antioxidant activities of Averrhoa carambola leaves

Moresco¹,

Queiroz²,

Pizzolatti³

et al. 2012

Rev. bras. farmacogn.

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“…Later, Vasconcelos et al investigated the effects of the aqueous extract of A. carambola leaves on cellular calcium influx by examining the left atrium of guinea pigs. The aqueous extract (1,500 μg/ml) had a positive inotropic effect (Vasconcelos et al., 2008). Soncini et al studied the effects of the Averrhoa carambola aqueous extract (AEAc) of leaves, in anesthetized normotensive rats (Soncini et al., 2011).…”

Section: Results and Discussion Of Trendsmentioning

confidence: 99%

Nutritional and medicinal properties of Star fruit (Averrhoa carambola): A review

Lakmal

Yasawardene

Jayarajah

et al. 2021

Food Science & Nutrition

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Star fruit (Averrhoa carambola), a popular fruit in many parts of the world, is considered to have many beneficial nutritional and medicinal effects. However, harmful nephrotoxic and neurotoxic effects have also been described. In this review, we have discussed the reported beneficial effects of star fruit, explored the potential mechanisms for such beneficial effects, and outline factors that may affect the safe level of consumption. The beneficial effects include the following: antioxidant (mediated via L‐ascorbic acid, epicatechin, and gallic acid), hypoglycemic (mediated via high fiber levels and 2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione), hypotensive (mediated via apigenin), hypocholesterolemic (mediated via micronized fiber), anti‐inflammatory, anti‐infective, antitumor effects, and immune‐boosting effects. The presence of chronic kidney disease, gastroenteropathies, chronic pancreatitis, dehydration, consumption on an empty stomach, and higher concentration of oxalate in fruit/juice consumed predisposes to toxicity. The level of ingestion at which the beneficial effects transition to nephrotoxicity and neurotoxicity is still to be accurately ascertained. Furthermore, the relationship between the amount of star fruit ingested and the severity of toxicity is not certain and warrants further study.

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“…An aqueous extract of leaves has induced various depressive effects on guinea pig heart, including atrioventricular block and cardiac rate slowing [105]. The same extract, used on guinea pig left atrium and pituitary GH3 cells, has induced hypotensive effects by inhibiting the inotropic action of the L-type Ca 2+ channel agonist BAY K 8644, and by blocking the L-type, inward calcium current in GH3 cells [106]. In agreement with these data, the leaf aqueous extract has induced hypotension on normotensive rats, and has inhibited aortic responses to phenylephrine and extracellular Ca 2+ , suggesting that the hypotensive effect is due at least in part to the inhibition of Ca 2+ influx [107].…”

Section: Cardiovascular Protectionmentioning

confidence: 99%

Emerging Exotic Fruits: New Functional Foods in the European Market

Cornara

Xiao

Smeriglio

et al. 2020

eFood

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KeywordsSuperfruits functional food dragon fruit cherimoya finger lime star fruit A B S T R A C TThe consumption of exotic fruits is rapidly increasing in European countries. Some of these products have attracted much interest due to their alleged properties of preventing malnutrition, over-nutrition, and disease, maintaining a healthy body. Scientific studies on these fruits are multiplying, including chemical characterizations and biological investigations on in vitro and in vivo experimental models. This review concerns four edible fruits: Hylocereus undatus (dragon fruit), Annona cherimola (cherimoya), Citrus australasica (finger lime), and Averrhoa carambola (carambola or star fruit). By screening biomedical databases, viz. Scopus, WOS, and PubMed, a total of 131 papers have been selected. Data reveals a wide series of biological effects that confirm traditional medicinal uses or suggest new therapeutic applications. Most studies concern problems related to nutrition, such as body redox balance, metabolic syndrome, and hepatoprotective effects, but other properties have been highlighted, including anticancer, antimicrobial, anti-inflammatory, and neuroprotective effects, as well as cardiovascular and skin protection. Pharmacological investigations have also been focused on specific compounds, assuming a potential role in drug discovery. In summary, food products, byproducts, and single compounds derived from these plants could be exploited in the prevention of disease or for specific treatments of health problems.

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Aqueous leaf extract of Averrhoa carambola L. (Oxalidaceae) reduces both the inotropic effect of BAY K 8644 on the guinea pig atrium and the calcium current on GH3cells

Cited by 5 publications

References 17 publications

Chemical constituents and evaluation of the toxic and antioxidant activities of Averrhoa carambola leaves

Chemical constituents and evaluation of the toxic and antioxidant activities of Averrhoa carambola leaves

Nutritional and medicinal properties of Star fruit (Averrhoa carambola): A review

Emerging Exotic Fruits: New Functional Foods in the European Market

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