Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats

Torrico, Fátima; Cepeda, Mariana; Guerrero, Geraldine; Melendez, Fidel David Huitzil; Blanco, Zuleima; Canelón, Dilsia J.; Diaz, Beth; Compagnone, Reinaldo S.; Suárez, Alírica I.

doi:10.1590/s0102-695x2007000200005

Cited by 25 publications

(17 citation statements)

References 18 publications

(12 reference statements)

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“…In this context, a genus with several species used in the folk medicine to treat different disorders is the genus Croton. Some of Croton species have been exhaustively studied with their medicinal and toxicological properties being scientifi cally proven (Souza et al, 2006;Costa et al, 2007;Perazzo et al, 2007;Salatino et al, 2007;Torrico et al, 2007). Other species of this genus were poorly studied, and their pharmacological properties and collateral effects are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)

Rocha¹,

Neto-Neves²,

Costa³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: "Avaliação dos efeitos antinociceptivo e antiinfl amatório de Croton pullei var. glabrior Lanj. (Euphorbiaceae)". Croton pullei var. glabrior Lanj. (Euphorbiaceae) é uma liana, amplamente distribuída na Floresta Amazônica. Na medicina popular, diversas plantas do gênero Croton têm sido utilizadas com fi ns terapêuticos em patologias que envolvem dor e infl amação, o que justifi ca este trabalho. O objetivo deste estudo foi investigar as atividades antinociceptiva e antiinfl amatória do extrato metanólico das folhas de C. pullei (MECP). O MECP reduziu, de forma dose-dependente, o número de contorções abdominais (1,2 %) em camundongos, sugerindo uma atividade antinociceptiva da planta. Por outro lado, o MECP não alterou signifi cativamente a reatividade ao estímulo térmico no teste da placa quente e a reatividade à estimulação química na primeira fase do teste da formalina, indicando um mecanismo não-opioidérgico. O MECP reduziu a nocicepção na segunda fase do teste da formalina, inibiu o edema de orelha induzido pelo óleo de croton e reduziu a migração leucocitária no teste da peritonite induzida por carragenina, indicando uma atividade antiinfl amatória. Apesar dos mecanismos responsáveis pelos efeitos da planta ainda não estarem completamente esclarecidos, estes resultados parecem justifi car o uso medicinal potencial de Croton pullei var. glabrior Lanj. em patologias que envolvam dor e infl amação.Unitermos: Antiinfl amatório, antinociceptivo, Croton pullei var. glabrior, fi tomedicina. ABSTRACT:Croton pullei var. glabrior Lanj. (Euphorbiaceae) is a liana, vastly distributed in the Amazonian Forest. In the folk medicine, several plants of the Croton genus have been used with therapeutic purposes in pathologies that involve painful and infl ammatory diseases which justify this work. The aim of this study was to investigate the antinociceptive and antiinfl ammatory activities of the C. pullei leaves methanol extract (MECP). MECP reduced in a dose-dependent manner the number of acetic acid-induced abdominal writhing (1.2%) in mice, suggesting an antinociceptive activity of the plant. On the other hand, MECP did not signifi cantly modify the reactivity to the thermal stimulation in the hot-plate test and the reactivity to the chemical stimulation in the formalin test fi rst phase, indicating a non-opioid mechanism. MECP reduced the formalin-induced nociception in the second phase, inhibited the croton oil-induced ear edema and reduced the leukocytes migration in the test of the carrageenan-induced peritonitis, indicating an antiinfl ammatory activity. Although the mechanisms that underlie these plant effects are not completely elucidated, these results appear to support the potential medicinal use of Croton pullei var. glabrior Lanj. against painful and infl ammatory diseases.

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Section: Introductionmentioning

confidence: 99%

Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)

Rocha¹,

Neto-Neves²,

Costa³

et al. 2008

Rev. bras. farmacogn.

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“…A 10% w/v homogenate was prepared in cold potassium phosphate buffer (50 mM, pH 7.4) using a Remi homogenizer. The unbroken cells and cell debris were removed by centrifugation at 3000 rpm for 10 min, using Remi C-24 refrigerated centrifuge (Torrico et al, 2007). The obtained supernatant were used for the following estimations: catalase (CAT) was estimated following the method of Abei (1984), superoxide dismutase (SOD) was assayed by the method of Kakkar et al (1984), the activity of glutathione peroxidase (GPX) was estimated by using the method of Paglia and Valentine (1967), reduced glutathione (GSH) was assayed according to Sener et al (2007), glutathione reductase (GR) was determined by the method of Racker (1955), glucose-6-phosphate dehydrogenase (G-6-PD) was estimated by using the method followed by Sudnikovich et al (2007), thiobarbituric acid reactive substances (TBARS), xanthine oxidase (XO) and xanthine dehydrogenase (XDH) activities were assayed employing the method of Fraga et al (1988) and Wang et al (2004) respectively.…”

Section: Experimental Designmentioning

confidence: 99%

Protective effect of Asystasia gangetica reduced oxidative damage in the small intestine of streptozotocin-induced diabetic rats

Kumar¹,

Umamaheswari²,

Sivashanmugam³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYOxidative stress plays an important role in the pathogenesis of various diabetic complications and small intestine is vulnerable to damage resulting in morphological and functional changes. In this study, the effects of Asystasia gangetica leaf extract (AGLE) on oxidative stress status in small intestine of diabetic rats were examined. The leaves of Asystasia gangetica was extracted with 70% ethanol. Oral administration of AGLE once daily (100 mg/kg and 200 mg/kg b.w.) for 28 days to diabetic rats significantly (P < 0.05) increased antioxidant levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione, GSSH, carbohydrate metabolizing enzyme, glucose-6-phosphate dehydrogenase. The increased levels of protein carbonyl content, lipid peroxidation and xanthine oxidase/xanthine dehydrogenase in diabetic rats were reverted back to near normal levels on treatment with AGLE. Both doses of AGLE offered significant activity (P < 0.01) against oxidative damage and were comparable with standard, glibenclamide. The results revealed the occurrence of oxidative stress in small intestine during diabetes and suggest the potential of AGLE as an antioxidant in protecting the tissue defense system against oxidative damage in streptozotocin-induced diabetes.

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“…Although the increased risk of cardiovascular diseases in diabetes is multifactorial, dyslipidemia is certainly a major factor. Thus, patients with diabetes are at increased risk for all the manifestations of atherosclerosis, including coronary artery disease, cerebrovascular events, and peripheral vascular diseases (Mohamed et al, 1999;Cavalli et al, 2007;Torrico et al, 2007;Figueiredo & Modesto-Filho, 2008;Janebro et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels, Myrtaceae. in diabetic rats

Schoenfelder¹,

Warmlin²,

M³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Efeito hipoglicêmico e hipolipidêmico das folhas de Syzygium cumini Lam. em ratos diabeticos". Na região de Criciúma-SC, as folhas de Syzygium cumini (L.) Skeels, Myrtaceae, conhecida popularmente como jambolão, são utilizadas para diminuir níveis de glicose plasmática em pessoas diabéticas. Dentro deste contexto o presente trabalho teve o interesse de avaliar o efeito hipoglicêmico e hipolipidêmico do extrato bruto hidroalcoólico (EBH) das folhas de S. cumini (125, 250 e 500 mg/kg). Para tal os animais foram divididos em três grupos para o efeito hipoglicêmico: ratos normais, ratos normais submetidos a curva de glicose (hiperglicêmicos) e ratos diabéticos induzidos com aloxana. O efeito hipolipidêmico foi avaliado em animais diabéticos induzidos por aloxana. O efeito hipoglicêmico foi comparado com glibenclamida. O tratamento agudo com EBH de S. cumini causou uma diminuição estatisticamente significativa na glicose sanguínea em animais normais que foram submetidos à cura de glicose (250 mg/kg), e sobre os níveis de glicose (125 e 250 mg/kg), triglicerídeo (125 e 500 mg/kg) e colesterol (125 mg/kg) em animais diabéticos. Nenhuma das doses testadas apresentou efeito em animais normais. Dentro deste contexto pode-se sugerir que o EBH das folhas de S. cumini pode ser uma alternativa terapêutica no tratamento alternativo ou complementar na diabete, uma vez que apresentou atividade hipoglicêmica e hipolipidêmica em animais diabéticos.Unitermos: Syzygium cumini, Myrtaceae, diabete, hipoglicêmico, hipolipidêmico, plantas medicinais.ABSTRACT: Ethanolic crude extract (ECE) of leaves from Syzygium cumini (L.) Skeels, Myrtaceae was screened for its hypoglycemic and hypolipidemic activity (125, 250 and 500 mg/kg v.o.). Rats were divided into three groups for the evaluation of the hypoglycemic effect: normal rats, rats with alloxan-induced diabetes and hyperglycemic normal rats. Hypolipidemia was evaluated in rats with alloxan-induced diabetes. The antihyperglycemic activity was compared to treatment with glibenclamide, an oral hypoglycemic agent. The acute treatment with S. cumini ECE caused a significant decrease in the blood glucose in hyperglycemic normal rats (250 mg/kg), and in glucose (125 and 250 mg/kg), triglyceride (125 and 500 mg/kg) and cholesterol (125 mg/kg) levels of diabetic rats, but no effect was observed in the normal treated rats. Syzygium cumini leaves are a good candidate for alternative and/or complementary medicine in the management of diabetes mellitus, since they showed hypoglycemic activity in addition to a hypolipidemic action in diabetic animals.

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Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats

Cited by 25 publications

References 18 publications

Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)

Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)

Protective effect of Asystasia gangetica reduced oxidative damage in the small intestine of streptozotocin-induced diabetic rats

Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels, Myrtaceae. in diabetic rats

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