Effects of the topical application of the extract of Vernonia scorpioides on excisional wounds in mice

Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats

“…The daily treatment presented enlarged damaged areas in the skin wounds after seven days, when compared with the control. However, this concentration did not inhibit the influx of mononuclear leukocytes, the proliferation of fibroblasts, or the formation of blood vessels observed after fourteen days (Dalazen et al, 2005).…”

“…Ulcers of the lower limb and foot frequently become infected with S. aureus, which is the most common pathogen in these infections (Nicolau & Stein, 2010) and if it is not treated promptly and appropriately, the treatment becomes more difficult, because the infection presents a barrier to healing (Bowling et al, 2009). It was demonstrated that non-infected skin ulcers treated with crude extract of V. scorpioides showed toxicity to the tissues when applied immediately after non-infected incision in mice (Dalazen et al, 2005). The crude extract can be dangerous in the initial wound healing stage in non-infected lesions, but our results showed that in infected ulcers this is not the case, indicating a possible antibacterial activity of V. scorpioides compounds.…”

Cytotoxic activity of the sub-fraction 2125 from Vernonia scorpioides against Sarcoma 180 tumor cells in mice

“…Previous studies of the Vernonia scorpioides crude extract have shown moderate bactericide activity and mild wound healing effects (Leite et al, 2002;Biavatti et al, 2007). We observed a pro-inflammatory profile of the crude extract from Vernonia scorpioides in healthy skin tissue (Dalazen et al, 2005). In our previous work we investigated the effect of the dichloromethane fraction (DCM) from the crude extract on Ehrlich ascitic and solid tumors in mice.…”

Avaliação dos efeitos da subfração Acetato de etila III de Vemonia scorpioides em modelo de melanoma murino in vivo e in vitro

“…Vários trabalhos encontrados na literatura referentes ao gênero Vernonia (Asteraceae) mostraram as atividades referentes a esse gênero de plantas (DALAZEN et al, 2005 TABOPTA et.al.2007;CHANG-LONG et al, 2008;ANDERSON et.al.2008;ROZENBLAT et.al. 2008 A ação citotóxica direta da subfração acetato de etila III, pode ser em parte, devido à presença de lactonas sesquiterpênicas contida nesta subfração, aos quais apresentam atividade antitumoral já descrita na literatura (BUSKUHL, 2007;KREUGER et al, 2009).…”

“…Estudos realizados indicaram atividade cicatrizante encontrada em Vernonia scorpioides, atividade antifúngica, o potencial de promoção de resposta reparadora, induzido por uma pomada contendo extrato bruto da planta, sendo que esta foi tóxica na fase aguda do processo inflamatório, o mesmo não aconteceu após 21 dias de tratamento, mostrando-se eficiente na resposta cicatricial, quando comparado ao grupo controle (ALMEIDA; PALHANO, 2001;CAMPOS, 2001;DALAZEN;MOLON, 2002).…”