Outros constituintes químicos de Diplotropis ferruginea Benth. (Fabaceae)

Almeida, Jackson Roberto Guedes da Silva; Cunha, Emídio Vasconcelos Leitão da; Silva, M.S.; Athayde-Filho, Petrônio Filgueiras de; Braz-Filho, Raimundo; Barbosa-Filho, José Maria

doi:10.1590/s0102-695x2003000400015

Cited by 3 publications

(4 citation statements)

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“…The crude ethanol extract (CEE) was obtained according to Almeida et al (2003). The dried and powdered stem-barks (10 kg) of D. ferruginea were extracted with EtOH (95%), yielding, 413 g of crude ethanolic extract (CEE).…”

Section: Extraction and Isolation Of Lupeolmentioning

confidence: 99%

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The triterpenoid lupeol attenuates allergic airway inflammation in a murine model

Vasconcelos

Teixeira

Barbosa-Filho

et al. 2008

International Immunopharmacology

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Asthma is a chronic inflammatory disease of the airways associated with a Th2 immune response. Despite their side effects, corticosteroids are the most used and effective drugs for treatment of asthma. In this work we investigated the efficacy of lupeol, a triterpenoid isolated from Lonchocarpus araripensis [corrected] Benth. (Fabaceae), in the treatment of bronchial asthma in BALB/c mice immunized with ovalbumin. Administration of lupeol caused the reduction of cellularity and eosinophils in the bronchoalveolar lavage fluid. Treatment with lupeol also reduced the production of mucus and overall inflammation in the lung. Levels of Type II cytokines IL-4, IL-5 and IL-13 were significantly reduced in mice treated with lupeol, an effect that was similar to that observed in dexamethasone-treated mice. In contrast, IgE production was not significantly altered after treatment with lupeol. In conclusion, our results demonstrate that lupeol attenuates the alterations' characteristics of allergic airway inflammation. The investigation of the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.

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Section: Extraction and Isolation Of Lupeolmentioning

confidence: 99%

“…It is also used in baths and washes external ulcers [20]. Previous chemical investigation has resulted in the isolation of flavonoids [21], benzenoids and a triterpene lupeol [22]. The flavonoid diplotropin isolated from D. ferruginea showed spasmolytic effect in guinea-pig ileum [23].…”

Section: Introductionmentioning

confidence: 99%

The triterpenoid lupeol attenuates allergic airway inflammation in a murine model

Vasconcelos

Teixeira

Barbosa-Filho

et al. 2008

International Immunopharmacology

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“…The % purity of lupeol used in the biological experiments as determined by highperformance liquid chromatography was 97%. Lupeol was identified based on nuclear magnetic resonance spectroscopic data and comparison with values reported in the literature (Almeida et al, 2003).…”

Section: Methodsmentioning

confidence: 99%

Antinociceptive Effect of Lupeol: Evidence for a Role of Cytokines Inhibition

Lima

Alves

Barbosa-Filho

et al. 2012

Phytotherapy Research

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The present study investigates the antinociceptive properties of lupeol in models of inflammatory and post-operative pain, as well as its mechanisms of action. The effects of lupeol were tested against acetic acid-induced writhing, formalin test, carrageenan-induced hyperalgesia, and post-operative pain model. Cytokine levels were determined by ELISA. Mice motor performance was evaluated in the rota rod and open-field tests. Pre-treatment of mice with lupeol (5-100 mg/kg IP) produced a dose-related inhibition of writhing in mice. The maximal antinociception produced by lupeol (60 mg/kg) was unaffected in mice pre-treated with yohimbine (α2 adrenoceptor antagonist; 2 mg/kg IP), L-arginine (substrate for nitric oxide synthase; 600 mg/kg IP), glibenclamide (the KATP-channel blocker; 2 mg/kg IP), and methysergide maleate (serotoninergic receptors antagonist; 5 mg/kg IP). Furthermore, lupeol (25-100 mg/kg) inhibited the late phase of formalin test. Pre-treatment with lupeol (50 and 100 mg/kg) inhibited the hyperalgesia and the local increase in tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels induced by carrageenan. In contrast, lupeol did not inhibit the post-operative pain. Lupeol-treated mice did not show any motor performance alterations or apparent systemic toxicity. Our results demonstrate that lupeol has consistent antinociceptive properties during inflammatory pain, but not post-operative pain, acting through the inhibition of IL-1β and TNF-α production.

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“…It is used in folk medicine for the treatment of rheumatism, arthritis and diabetes. 4 Recently, a chemical investigation of this species resulted in the isolation of lupeol, ethyl 2-hydroxy-4-methoxy-6-propyl benzoate 5 and of the flavonoid 3,4,5,8-tetramethoxy-6,7,2",3"-furanoflavan. 6 Spasmolytic activity was reported for the crude EtOH extract of this plant.…”

Section: Introductionmentioning

confidence: 99%