Diterpenos isolados de Humirianthera ampla. Miers.

Abstract

From Humirianthera ampla, Icacinaceae, were isolated a phthalate, lupeol, β-sitosterol, glycosyl-sitosterol, one known annonalide diterpene and two new diterpenes named Humirianthol and Acrenol. Humirianthol and Acrenol were determined by 1D and 2D NMR spectroscopic techniques to be 3 β, 20:14 β, 16-diepoxy-3 α, 15 α-dihydroxy-7-pimaren-19, 6 β-olide and 3 β, 20-epoxi-3 α, 15, 16-trihydroxy-7-pimaren-19, 6 β-olide, respectively. Acrenol has antimicrobial activity.A planta Humirianthera ampla, pertence a família das Icacinaceas e é predominante da Amazônia

Antinociceptive action of ethanolic extract obtained from roots of Humirianthera ampla Miers

“…Studies of chemical constituents of this plant revealed the presence of the di and triterpenoids: annonalide, humirianthol, acrenol and lupeol. In addition, substances as ␤-sitosterol and glycosylated sitosterol were also isolated from the ethanolic extract (EE) from the roots of Humirianthera ampla (Graebner et al, 2000(Graebner et al, , 2002. The presence of these compounds might explain the exceptional effect of the Humirianthera ampla against inflammation and pain caused by snake bite and consequently validates the large use of this plant by the Amazonia native people in this condition.…”

Semisynthesis and absolute configuration of a novel rearranged 19,20-δ-lactone (9βH)-pimarane diterpene

“…(9H)-Pimarane diterpenes are commonly found in Icacinacea species (Graebner et al, 2000(Graebner et al, , 2002Burrow et al, 2003;Adou et al, 2005;Onakpa et al, 2014;Zhao et al, 2015). Most of the representatives of this class of natural products, such as annonalide (1, Fig.…”