Aplicação da termogravimetria (TG) no controle de qualidade da milona (Cissampelos sympodialis Eichl.) Menispermaceae

Abstract

This work proposes the application of the thermogravimetry (TG) in the control of quality of Cissampelos sympodialis, known popularly as 'milona'. After the extraction process, the alkaloids became the majority substances and the extracts showed the kinetic behavior of the bisbenzylisoquinoline alkaloids. This seems to be an important and useful parameter for the quality control of the 'milona' extracts.

Cissampelos sympodialis Eichl. (Menispermaceae), a medicinal plant, presents antimotility and antidiarrheal activity in vivo

“…Several chemical compounds belonging to the alkaloids class have been isolated from the specie’s leaves and roots, as examples the: bisbenzylisoquinolinic (warifteine, methylwarifteine, roraimine, and simpodialine); morphinic (milonine); aporphinic (laurifolin) and oxo-aporphinic (liriodenine) alkaloids [ 13 , 14 ]. Quality control studies have shown that both alcoholic fractions of the leaves (AFLs), and alcoholic fractions of the roots (AFRs) present alkaloids as their principal compounds, being warifteine the chemical marker of both AFL and AFR [ 15 ]. Crude ethanolic extract (EtOHE- Cs ) was standardized using warifteine and methylwarifteine as markers that were also found in the total alkaloid fraction (TAF- Cs ) [ 16 ].…”

Processing and Quality Control of Herbal Drugs and Their Derivatives

“…Among several papers published in this area, the most outstanding ones are: application of thermogravimetry (TG) in quality control of Milon (Cissampelos sympodialis Eichi.) Minispermaceae (Aragão et al, 2002), thermal analysis and compatibility study of zidovudine with excipients (Araujo et al, 2003); study of thermal stability of metronidazole tablets ; Thermal analysis study of captopril coated tablets by thermogravimetry (TG) and differential scanning calorimetry (DSC) (Bazzo & SILVA, 2005); thermoanalytical study of glibenclamide and excipients (Oliveira et al, 2004); thermoanalitycal study (TG, DTG and DSC) of in natura and processed coffee ; study, characterization and determination of the purity of commercial samples of saccharin ; determination of moisture content and ash content of commercial samples of guarana using conventional methods and thermal analysis (ARAÚJO et al, 2006); physicochemical characterization of fluid and spray dried extracts of Symphytum officinale L. , assessing the compatibility between fluoxetine and excipients used in the manufacture of capsules (Stulz & Tagliari, 2006); thermoanalytical study and drug-excipient compatibility of rifampicin and some medications used in the treatment of Tuberculosis (Alves, 2007), thermal stability and compatibility of hydroquinone (Tagliari et al, 2008).…”