Estudo da atividade antidiarréica e antisecretória intestinal do látex do Croton urucurana Baill

Gurgel, Luilma Albuquerque; Martins, Domingos Tabajara de Oliveira; Mattos, Paulo Orlandi; Rao, V. S. N.

doi:10.1590/s0102-695x2002000300019

Cited by 8 publications

(6 citation statements)

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“…Activated charcoal, employed in the gastrointestinal transit model as a marker, has been used for over 60 years as a simple tool for evaluating the effect of laxatives (Gaginella et al, 1994). This method is an indicator of the maximum distance traveled by the marker (activated charcoal) through its administration and the assessment of its path in the small intestine over a period of time (Gurgel, 2000). According to this model, the results of oral administration of atropine (2 mg/kg) show that there was significant inhibition of the distance traveled by charcoal in the intestine of mice of circa 32.7±3.6%, when compared to the negative control (0.9% saline+Cremophor ® ).…”

Section: Resultsmentioning

confidence: 99%

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Antidiarrheal activity of Solanum asterophorum in mice

Silva¹,

Neto²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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Several species of Solanum are used in folk medicine to treat diarrhea. Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of methanol extracts from roots (Sast-MeOH R ) and leaves (Sast-MeOH L ) of Solanum asterophorum Mart., Solanaceae, in mice. Sast-MeOH R was shown to significantly and dose-relatedly inhibit the frequency of both solid (ED50 309.6±28.5 mg/kg) and liquid (ED50 152.1±32.5 mg/kg) stools. Conversely, SastMeOH L significantly inhibited solid stool frequency only when dosed at 500 and 750 mg/kg (48.7±7.4 and 42.3±9.8%, respectively), but also significantly and doserelatedly inhibited liquid stools (ED50 268.4±35.2 mg/kg). Thus, Sast-MeOH R was twice as potent as Sast-MeOH L in diarrhea inhibition. Neither extracts (when dosed up to 500 mg/kg) inhibited intestinal transit. However, both extracts significantly and dose-relatedly inhibited intestinal fluids, and Sast-MeOH R (ED50 38.3±10.4 mg/kg) was again twice as potent as Sast-MeOH L (ED50 78.6±6.4 mg/kg). Results suggest that antidiarrheal effects of Sast-MeOH R and Sast-MeOH L involve changes on intestinal secretion. In addition, active metabolites with antidiarrheal activity may be more concentrated in the roots of this species. However further studies are needed to elucidate the action mechanism involved in this activity.

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Section: Resultsmentioning

confidence: 99%

“…This enhanced secretory capacity is clearly shown through the administration of large amounts of castor oil (Gurgel, 2000). Thus, we assessed the effects of Sast-MeOH R and Sast-MeOH L extracts in mice using a castor oil-induced intestinal fluid accumulation model and evaluated the fluid amount in comparison to the control group.…”

Section: Resultsmentioning

confidence: 99%

Antidiarrheal activity of Solanum asterophorum in mice

Silva¹,

Neto²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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“…Diarrhea caused by castor oil occurs due to the formation of ricinoleic acid in the intestinal lumen and leads to changes in intestinal homeostasis ( Bakare et al, 2010 ), thereby increasing fluid secretion ( Gurgel et al, 2002 ). Our data showed that the volume and weight of intestinal contents could be both significantly inhibited by luteolin and scutellarein with the inhibition rates of 25.94% and 31.88% ( p < 0.05) ( Figures 4A,B ).…”

Section: Resultsmentioning

confidence: 99%

The Active Ingredients Identification and Antidiarrheal Mechanism Analysis of Plantago asiatica L. Superfine Powder

Dong

et al. 2021

Front. Pharmacol.

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Plantago asiatica L. is a natural medicinal plant that has been widely used for its various pharmacological effects such as antidiarrheal, anti-inflammatory, and wound healing. This study aims to explore the antidiarrheal active ingredients of Plantago asiatica L. that can be used as quality markers to evaluate P. asiatica L. superfine powder (PSP). Molecular docking experiment was performed to identify the effective components of P. asiatica L., which were further evaluated by an established mouse diarrhea model. Na+/K+-ATPase and creatine kinase (CK) activities and the Na+/K+ concentrations were determined. The gene expression of ckb and Atp1b3 was detected. PSP was prepared and evaluated in terms of the tap density and the angle of repose. The structures of PSPs of different sizes were measured by infrared spectra. The active ingredient contents of PSPs were determined by HPLC. The results indicated that the main antidiarrheal components of P. asiatica L. were luteolin and scutellarein that could increase the concentration of Na+ and K+ by upregulating the activity and gene level of CK and Na+/K+-ATPase. In addition, luteolin and scutellarein could also decrease the volume and weight of small intestinal contents to exert antidiarrheal activity. Moreover, as the PSP size decreased from 6.66 to 3.55 μm, the powder tended to be amorphous and homogenized and of good fluidity, the content of active compounds gradually increased, and the main structure of the molecule remained steady. The optimum particle size of PSP with the highest content of active components was 3.55 μm, and the lowest effective dose for antidiarrhea was 2,000 mg/kg. Therefore, the antidiarrheal active ingredients of PSP were identified as luteolin and scutellarein that exert antidiarrheal activity by binding with Na+/K+-ATPase. PSP was successfully prepared and could be used as a new dosage form for the diarrhea treatment.

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“…C. urucurana Baill. (600 and 800 mg/kg) has been reported that significant antidiarrheal effect[ 28 ] and several Croton species are used in folk medicine as anti-diarrheal, e.g. C. cajucara ,[ 13 ] C. tiglium ,[ 14 ] and C. urucurana .…”

Section: Resultsmentioning

confidence: 99%

Croton grewioides Baill. (Euphorbiaceae) shows antidiarrheal activity in mice

Silva¹,

Silva²,

Neto³

et al. 2016

Phcog Res

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Based on chemotaxonomy, we decided to investigate the possible antidiarrheal activity in mice of a crude ethanolic extract obtained from aerial parts of Croton grewioides (CG-EtOH). We tested for any possible toxicity in rat erythrocytes and acute toxicity in mice. Antidiarrheal activity was assessed by determining the effect of CG-EtOH on defecation frequency, liquid stool, intestinal motility and intestinal fluid accumulation. CG-EtOH showed no in vitro cytotoxicity and was not orally lethal. In contrast, the extract given intraperitoneally (at 2000 mg/kg) was lethal, but only in females. CG-EtOH produced a significant and equipotent antidiarrheal activity, both in defecation frequency (ED50 = 106.0 ± 8.1 mg/kg) and liquid stools (ED50 = 105.0 ± 9.2 mg/kg). However, CG-EtOH (125 mg/kg) decreased intestinal motility by only 22.7% ± 4.4%. Moreover, extract markedly inhibited the castor oil-induced intestinal contents (ED50 = 34.6 ± 5.4 mg/kg). We thus conclude that CG-EtOH is not orally lethal and contains active principles with antidiarrheal activity, and this effect seems to involve mostly changes in intestinal secretion.SUMMARY CG-EtOH showed no in vitro cytotoxicity and was not orally lethal. In contrast, the extract given intraperitoneally (at 2000 mg/kg) was lethal, but only in females.CG-EtOH probably contains active metabolites with antidiarrheal activity.CG-EtOH reduced the frequency and number of liquid stools.Metabolites presents in the CG-EtOH act mainly by reducing intestinal fluid and, to a lesser extent, reducing intestinal motility. Abbreviations Used: CG-EtOH: crude ethanolic extract obtained from the aerial parts of C. grewioides; WHO: World Health Organization; ED50: dose of a drug that produces 50% of its maximum effect; Emax: maximum effect

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Estudo da atividade antidiarréica e antisecretória intestinal do látex do Croton urucurana Baill

Cited by 8 publications

References 0 publications

Antidiarrheal activity of Solanum asterophorum in mice

Antidiarrheal activity of Solanum asterophorum in mice

The Active Ingredients Identification and Antidiarrheal Mechanism Analysis of Plantago asiatica L. Superfine Powder

Croton grewioides Baill. (Euphorbiaceae) shows antidiarrheal activity in mice

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