Caracterização farmacognóstica da pata-de-vaca Bauhinia forficata Link

Myiake, E T; Akisue, Gokithi; Akisue, Maria Kubota

doi:10.1590/s0102-695x1986000100007

Cited by 32 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(Fabaceae) is a small tree reaching up to 9 m height, native to the tropical area of Asia, Paraguay and Argentina, and is well adapted to the Brazilian climate. The leaves (7 -12 cm £ 13 cm) are alternate, simple, petiolate, bilobate to about one-third, or, more frequently to half of their length, rounded at the base, pubescent beneath; due to the characteristic shape of the leaves, this species is commonly known as 'Pata de Vaca' (cow's hoof) (Miyake et al 1986;Da Silva et al 2000). B. forficata is the Bauhinia species most used as an antidiabetic herbal remedy in popular medicine in Brazil, where it is defined also as 'vegetable insulin'.…”

Section: Introductionmentioning

confidence: 99%

Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract

Miceli

Buongiorno

Celi

et al. 2015

Natural Product Research

View full text Add to dashboard Cite

Bauhinia forficata Link. is utilised as an antidiabetic in Brazilian folk-medicine; furthermore, its antioxidant properties suggest a potential usefulness in the prevention of diabetes complications associated with oxidative stress. The contribution of a flavonoid-rich fraction (FRF), HPLC-PDA-ESI-MS characterised, to the antioxidant and cytotoxic properties of B. forficata hydro-alcoholic leaves extract was evaluated for the first time. Both extract and FRF showed radical-scavenging activity and reducing power with a strong relationship with the flavonoid content found; hence, flavonoids are mainly responsible for the primary antioxidant activity of B. forficata extract. The extract significantly decreased FO-1 cell viability at the higher concentrations. FRF did not exert any effect; thus, flavonoids do not appear to be responsible for the cytotoxicity of the extract. The extract resulted virtually non-toxic against both Artemia salina and normal human lymphocytes, demonstrating potential selectivity in inhibiting cancer cell growth. Finally, no antimicrobial activity was observed against the bacteria and yeasts tested.

show abstract

Section: Introductionmentioning

confidence: 99%

Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract

Miceli

Buongiorno

Celi

et al. 2015

Natural Product Research

View full text Add to dashboard Cite

show abstract

“…Esta informação é de extrema importância para análise de qualidade, uma vez que existe uma diversidade de preparações disponíveis no mercado a base de folhas de B. forfi cata. Por existir uma similaridade macroscópica entre as diversas espécies de Bauhinia (Miyake et al, 1986;Duarte & Debur, 2003;Ferreira et al, 2003), a adulteração das preparações vegetais é muito comum e, aliado a isto, as condições pelas quais as plantas se desenvolvem podem alterar a composição do material vegetal (Niero et al, 2003;Gobbo-Neto & Lopes, 2007). Considerando que no mercado farmacêutico há uma grande variedade de chás, aos quais se atribuem as propriedades da B. forfi cata, neste trabalho realizou-se um controle de qualidade destas preparações utilizando kaempferitrina como um marcador químico para aferir a qualidade dos produtos expostos à venda.…”

Section: Introductionunclassified

Controle de qualidade de drogas vegetais a base de Bauhinia forficata Link (Fabaceae)

Engel¹,

Ferreira²,

Cechinel‐Filho³

et al. 2008

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO:Este trabalho teve como objetivo utilizar métodos de controle de qualidade para algumas drogas vegetais a base de Bauhinia forfi cata comercializadas nos municípios de Itajaí e Balneário Camboriú, utilizando como marcador químico o fl avonóide kaempferitrina. As metodologias empregadas foram cromatografi a em camada delgada (CCD) e cromatografi a líquida de alta efi ciência (CLAE), além da análise microscópica, análise de rótulos e características organolépticas e a presença de material estranho. Todas as análises foram comparadas com os resultados demonstrados pela amostra autêntica, devidamente identifi cada, de B. forfi cata (A). Foram analisadas 06 amostras a base de Bauhinia identifi cadas através de siglas, sendo a B. forfi cata autêntica a amostra A e seis comerciais denominadas B-G. Todas as amostras comerciais foram reprovadas quanto à presença de material estranho, fi cando acima de 2%. Na análise microscópica observou-se que apenas a amostra E e G apresentam-se iguais à B. forfi cata. A análise cromatográfi ca revelou a presença de kaempferitrina somente nas amostras B, C, E e G. Unitermos: Bauhinia forfi cata, controle de qualidade, kaempferitrina.ABSTRACT: "Quality control of drugs with Bauhinia forfi cata Link (Fabaceae)". The present study aimed to use methods to perform the quality control of some vegetal drugs based on Bauhinia forfi cata from Itajaí and Balneário Camboriú, using the fl avonoid kaempferitrin as chemical marker. The methods used were thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), besides microscopic analysis, label analysis and organoleptic characteristics and strange material presence. All the analyses were compared with the authentic sample of B. forfi cata (A) results. This study used six commercial samples which were denoted as B-G. In the strange material analyses, all the samples were disapproved because they were above 2%. Microscopic analyses revealed that only B and G samples were identical to B. forfi cata (A). The chromatographic results suggested that only the samples B, C, E and G presented kaempferitrin.

show abstract

“…The strain TA 100 detects basepair substitution mutation in the codon GC of the gene that codifys for histidine his G46 . In B. for-cata, guanidine and flavonoids (Miyake et al, 1986;Oliveira and Saito, 1987-89) were reported. Compounds such as hydrocyanic acid and the flavonoids quercetin, quercitrin, and rutin were also reported in the genus Bauhinia (Duke, 1985).…”

Section: Resultsmentioning

confidence: 98%

Genotoxicity assessment through the Ames test of medicinal plants commonly used in Brazil

Rivera

Martins

Sanchez³

et al. 1994

Environ. Toxicol. Water Qual.

View full text Add to dashboard Cite

Ten medicinal herbs commonly used as popular medicine in Brazil—Bauhinia forficata L., Bauhinia variegata L., Cymbopogon citratus D.C. Stapf, Echinodorus macrophyllum (Kunth) Micheli, Hidrocotyle asiatica L, Matricaria chamomila L., Pfaffia iresinoides (Kunth) Sprengel, Plaffia paniculata (Martius) Kuntze, Phyllanthus tenellus Roxb, and Solidago microglossa D.C.—were tested for mutagenicity by the Ames test using Salmonella typhimurium TA 97a, TA 98, TA 100, and TA 104 strains, with and without metabolic activation. The genotoxicity assessment of these medicinal plants was performed in aqueous extracts 1:5. Seventy percent of these herbs presented mutagenic effects with at least one of the Ames strains used in this study. Bauhinia variegata L., E. macrophyllum K., and M. chamomilla L. showed no mutagenic activity. The mutagenic effects were detected mainly with the strains TA 98 related to frameshift mutations. The higher mutagenicity ratio was obtained with S. microglossa D.C. (known as arnica‐do‐Brazil) when TA 98 strain was used with metabolic activation (MR = 6.55) and with TA 97a strain with and without the addition of S9. Medicinal plants are now used by all the segments of the population, more intensively in the last years. These results indicate the need to establish rules to assess the safety of the use of medicinal herbs. © 1994 by John Wiley & Sons, Inc..

show abstract

Caracterização farmacognóstica da pata-de-vaca Bauhinia forficata Link

Cited by 32 publications

References 0 publications

Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract

Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract

Controle de qualidade de drogas vegetais a base de Bauhinia forficata Link (Fabaceae)

Genotoxicity assessment through the Ames test of medicinal plants commonly used in Brazil

Contact Info

Product

Resources

About