Partial gastrectomy associated to anterior truncal vagotomy: alterations in metabolism of the calcium. Experimental study in rats

Santos, Elisvânia Freitas dos; Tsuboi, Kathia Hitomi; Palu, Beatriz Frolini; Araújo, Marina Rachel; Andreollo, Nelson Adami; Miyasaka, Célio Kenji

doi:10.1590/s0102-67202009000200008

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…After the gastric resection the content of calcium in the bone is reduced and became more pronounced during the time 12 . These results were observed in other studies 5,1,12,16,17 . Patients submitted to bariatric surgery present micronutrient deficiencies of vitamin B12, iron, calcium, and vitamin D, and nutrient and mineral supplementation are essential for the treatment and prevention of nutritional and metabolic complications 8 .…”

Section: Discussionsupporting

confidence: 89%

Dietary polydextrose increases calcium absorption in normal rats

Santos¹,

Tsuboi²,

Araújo³

et al. 2009

ABCD, arq. bras. cir. dig.

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BACKGROUND: Gastric surgery is known to cause bone disorders, possibly related to an impaired capacity for the absorption of dietary calcium. AIM: To verify if polydextrose (PDX) could stimulate calcium absorption in partially gastrectomized and sham operated rats. METHODS: The rats were laparotomized (sham-operated control) or partially gastrectomized (Billroth II), in groups of 20 each. Half in each operated group were fed a control diet (AIN-93M) without PDX or the same diet containing (PDX 50g/Kg of diet) for eight weeks. The rats were divided into four subgroups: sham-operated and gastrectomized without PDX; sham-operated and gastrectomized with PDX. On the final day of the study, total blood was collected for determination of serum calcium concentration. RESULTS: In the diet with PDX, excretion of calcium in the feces was significantly lower than in the groups not receiving PDX, irrespective of the operation. Apparent calcium absorption and serum calcium was higher in the sham operated PDX fed group than in the control group. In sham operated rats, the calcium concentration in bone was higher in the PDX fed group. CONCLUSION: The polydextrose feeding increased calcium absorption and bone calcium concentration in normal rats, which may be relevant for decreasing the risk of osteoporosis. Partially gastrectomy did not affect the bone calcium concentration in 56 days of experimental period.

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Section: Discussionsupporting

confidence: 89%

Dietary polydextrose increases calcium absorption in normal rats

Santos¹,

Tsuboi²,

Araújo³

et al. 2009

ABCD, arq. bras. cir. dig.

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“…Previous studies showed that the partial gastrectomy associated to anterior truncal vagotomy were a good experimental model to study the iron metabolism 21 and calcium metabolism 22 . However, the etiology of iron malabsorption after gastrectomy has not been fully clarified.…”

Section: Discussionmentioning

confidence: 99%

A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

Santos¹,

Tsuboi²,

Araújo³

et al. 2011

ABCD, arq. bras. cir. dig.

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headings -Prebiotics. Gastrectomy. Iron. Anemia. Rats.abstRact -Background -The ingestion of two prebiotics, galactooligosaccharide (GOS) and polydextrose (PDX), leads to an increase in iron absorption and promotes recovery from anemia in gastrectomized rats. Aim -To study whether GOS + PDX stimulate iron absorption in gastrectomized and normals rats. Methods -Rats were laparotomized (sham-operated control) and partially gastrectomized (Billroth II) in groups of 20 each. Animals from both treatments were subsequently fed a control diet (AIN-93M) or the same diet supplemented with GOS and PDX (25 g/Kg of diet each) for eight weeks. They were divided into four subgroups, i.e., sham-operated and gastrectomized without GOS + PDX, sham-operated and gastrectomized with GOS + PDX. Two rats died during the experiment. All gastrectomized rats received an intramuscular injection of vitamin B-12 every two weeks. Hematocrit (HCT) and hemoglobin concentration (HGB) were measured at the start and on day 30 and 56 days after the start of feeding. On the final day of the study, total blood was collected for determination of serum iron concentration. Results -In the diet with GOS + PDX, iron excretion in feces was significantly lower than without the prebiotics. Apparent iron absorption and serum iron was higher in the GOS + PDX fed groups (both sham operated and gastrectomized) than in the non-GOS + PDX fed groups. The HCT and HGB concentrations were significantly lower in gastrectomized rats than in the control group, however, GOS + PDX feeding improved HGB levels in this group. ConclusionThe association of the GOS + PDX increase absorption of iron in sham-operated and gastrectomized rats and still prevent postgastrectomy anemia.Resumo -Racional -Ratos gastrectomizados desenvolvem anemia, e a ingestão de galactooligossacarídeo (GOS) e a polidextrose (PDX) aumenta a absorção de ferro e promove a recuperação da anemia em ratos com deficiência de ferro. Objetivo -Avaliar se GOS e PDX estimulam a absorção de ferro em ratos gastrectomizados e normais. Métodos -Os ratos foram laparotomizadas (controle falso-operado) e parcialmente gastrectomizados (Billroth II) em grupos de 20 animais. Os animais de ambos os tratamentos foram posteriormente submetidos à dieta controle (AIN-93M) ou a mesma dieta suplementada com GOS e PDX (25 g/kg de dieta cada) durante oito semanas e divididos em quatro subgrupos: sham-operados e gastrectomizados sem GOS e PDX, sham-operados e gastrectomizados com GOS e PDX. Dois animais morreram durante o experimento. Todos os ratos gastrectomizados receberam uma injeção intramuscular de vitamina B-12 a cada duas semanas. Hematócrito (HCT) e concentração de hemoglobina (HGB) foram dosados no início e nos dias 30 e 56 dias após o início da alimentação. No último dia do estudo, o sangue total foi coletado para determinação da concentração de ferro sérico. Resultados -Na dieta com GOS e PDX a excreção de ferro nas fezes foi significativamente menor do que no grupo sem prebióticos. Absorção aparente de ferro e ferro sé...

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“…This fact added to the reduced gastric capacity and the absence hydrochloric acid increases the iron and other nutrients deficiencies 15 . Previous studies showed that the partial gastrectomy associated to anterior truncal vagotomy were a good experimental model to study the iron metabolism 27 and calcium metabolism 28 .…”

Section: Fecal Iron and Apparent Iron Absorptionmentioning

confidence: 99%

Ingestion of polydextrose increase the iron absorption in rats submitted to partial gastrectomy

et al. 2010

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Purpose: To investigate whether polydextrose stimulates iron absorption in rats submitted to partial gastrectomy and sham operated. Methods: The rats were submitted to partial gastrectomy (Billroth II) or laparotomy (sham-operated control), in groups of 20 and 20 each respectively. The animals were fed with a control diet (AIN-93M) without polydextrose or a diet containing polydextrose (50g/Kg of diet) for eight weeks. They were divided into four subgroups: sham-operated and Billroth II gastrectomy and with or without polydextrose. Two animals died during the experiment. All rats submitted to gastrectomy received B-12 vitamin (intramuscular) each two weeks. The hematocrit and hemoglobin concentration were measured at the start and on day 30 and 56 after the beginning of the experimental period. At the end of the study, the blood was collected for determination of serum iron concentration. Results: The diet with polydextrose reduced the excretion of iron. Apparent iron absorption was higher in the polydextrose fed groups than in the control group. The haematocrit and haemoglobin concentration were lower after Billroth II gastrectomy rats fed the control diet as compared to the polydextrose diet groups. Conclusion: Polydextrose increase iron absorption and prevents postgastrectomy anemia. Key words: Prebiotics. Gastrectomy. Iron. Anemia. Rats. RESUMOObjetivo: Investigar se a polidextrose estimula a absorção de ferro em ratos submetidos à gastrectomia parcial e sham operados. Métodos: Os ratos foram submetidos à gastrectomia parcial (Billroth II) e à laparotomia (controle sham-operados) em grupos de 20 e 20 cada, respectivamente. Os animais foram alimentados com uma dieta controle (AIN-93M), sem polidextrose ou uma dieta contendo polidextrose (50g/kg de dieta) durante oito semanas. Foram divididos em quatro grupos: sham-operados e com gastrectomia BII e com ou sem polidextrose. Dois animais morreram durante o experimento. Todos os ratos com gastrectomia receberam vitamina B-12 (intramuscular) a cada duas semanas. O hematócrito e a hemoglobina foram dosados no início e nos dias 30 e 56 após o início do período experimental. No final do estudo, o sangue foi coletado para determinação da concentração de ferro sérico. Resultados: A dieta com polidextrose reduziu a excreção de ferro e a absorção de ferro aparente foi maior nos grupos alimentados com polidextrose do que no grupo controle. As dosagens de hematócrito e hemoglobina foram menores em ratos com gastrectomia alimentados com a dieta controle em relação aos grupos de dieta com polidextrose. Conclusão: A polidextrose aumenta a absorção do ferro e previne a anemia pós-gastrectomia.

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Partial gastrectomy associated to anterior truncal vagotomy: alterations in metabolism of the calcium. Experimental study in rats

Cited by 6 publications

References 17 publications

Dietary polydextrose increases calcium absorption in normal rats

Dietary polydextrose increases calcium absorption in normal rats

A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

Ingestion of polydextrose increase the iron absorption in rats submitted to partial gastrectomy

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