Modelo experimental para o estudo da hérnia do disco intervertebral

Grava, André Luiz de Souza; Ferrari, Luiz F.; Parada, Carlos Amílcar; Defino, Helton La

doi:10.1590/s0102-36162008000300003

Cited by 4 publications

(2 citation statements)

References 28 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Roto-rod, although initially designed for forced ambulation on gait in lesions of the cerebellum 15 , is also used in the grading of joint function in experimental neurological compressions 27 , and joint changes in experimental arthritis of the knees 16,25 . This study showed that the greatest difference occurred in 7 and 14 days after induction.…”

Section: Control Group (Cg)mentioning

confidence: 99%

Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee

et al. 2016

View full text Add to dashboard Cite

PURPOSE:To evaluate the usefulness of a knee osteoarthritis model through functional, radiological and microscopic changes of the synovial membrane. METHODS:Forty eight rats were divided randomly into two groups. The first received 0.9% saline in the joint and corresponded to the control group. The second was submitted to experimental osteoarthritis of the right knee induced by monosodium iodoacetate and corresponded to the osteoarthritis group. All animals were subjected to comparative tests of forced ambulation and joint movements, inability to articulate and tactile allodynia on day 1 post-experiment by forced ambulation (Roto-rod test), joint assessment of disability (weight bearing test) and assessment of tactile allodynia (Von Frey test). After inflammatory induction they were divided into four subgroups corresponding to the scheduled death in 7, 14, 21 and 28 days when they were submitted to radiographic examination of the knee, arthrotomy and collection of the synovial membrane. RESULTS:The osteoarthritis group showed significant differences compared to control group on days 7 and 14 in Roto-rod, in weight bearing and Von Frey tests in all days, and in radiological evaluation. Microscopic examination of the synovial membrane showed abnormalities of inflammatory character at all stages. CONCLUSION:The osteoarthritis induced by intra-articular monosodium iodoacetate in rats knee is a good model to be used in related research, because it provides mensurable changes on joint movements, tactile allodynia, progressive radiological degeneration and microscopic inflammation of the synovial membrane, that represent markers for osteoarthritis evaluation

show abstract

Section: Control Group (Cg)mentioning

confidence: 99%

Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Cada disco é feito de uma parte interna gelatinosa e macia cercada por um revestimento externo duro e fi broso. Quando parte desta estrutura sai de sua posição normal, ocorre ruptura do anel fi broso, com subsequente deslocamento da massa central do disco nos espaços intervertebrais, e consequentemente comprimem as raízes nervosas CORDEIRO, 2002;ASSOCIAÇÃO, 2013;NEGRELLI, 2001;GRAVA, 2008).…”

unclassified

Comparação da flexibilidade, intensidade da dor e funcionalidade de portadores de hérnia discal submetidos à hidrocinesioterapia versus cinesioterapia clássica

2015

View full text Add to dashboard Cite

<p>O objetivo deste estudo foi comparar a flexibilidade, intensidade de dor, mobilidade e força muscular de portadores de hérnia discal submetidos a tratamento por cinesioterapia versus hidrocinesioterapia. Os participantes do estudo foram 40 voluntários com diagnóstico médico de hérnia discal, randomizados por sorteio simples em dois grupos: 24 no grupo de cinesioterapia (GC) com média de idade de 50,6 ± 11,0 anos e 15 no grupo hidrocinesioterapia (GH) com média de idade de 50,5 ± 5,7 anos. Os programas consistiram em duas sessões semanais de uma hora durante cinco semanas. Os voluntários realizaram antes e depois das 10 sessões avaliações quanto à mobilidade funcional (Teste Timed Up & Go), intensidade da dor (Escala Visual Analógica), flexibilidade da coluna lombar (Banco de Wells - Figure Finder Flex - Teste) e força muscular (dinamômetro). A análise estatística foi feita com o uso do Mann-Whitney U-test. Em todos os casos, o nível descritivo α estabelecido foi de p< 0,05. Foi observado melhora significativa na mobilidade e intensidade da dor nos dois grupos. Ao compararmos o efeito de melhora entre os grupos, não houve diferença significativa. Sendo assim, ambas as técnicas conseguiram diminuir a dor e melhorar a mobilidade, embora não tenham melhorado a flexibilidade e a força muscular.</p>

show abstract

Pharmacologic Treatment of Hyperalgesia Experimentally Induced by Nucleus Pulposus

Grava

Ferrari

Parada

et al. 2010

Revista Brasileira de Ortopedia (English Edition)

Self Cite

View full text Add to dashboard Cite

Objective: To evaluate the effect of anti-inflammatory drugs (dexamethasone, indomethacin, atenolol and indomethacin plus atenolol) and analgesic drugs (morphine) on hyperalgesia experimentally induced by the nucleus pulposus (NP) in contact with the L5 dorsal root ganglion (DRG). Methods: Thirty male Wistar rats of weights ranging from 220 to 250 g were used in the study. Hyperalgesia was induced by means of a fragment of NP removed from the sacrococcygeal region that was placed in contact with the L5 dorsal root ganglion. The 30 animals were divided into experimental groups according to the drug used. The drugs were administered for two weeks after the surgical procedure to induce hyperalgesia. Mechanical and thermal hyperalgesia was evaluated using the paw pressure test, von Frey electronic test and Hargreaves test, over a seven-week period. Results: The greatest reduction of hyperalgesia was observed in the group of animals treated with morphine, followed by dexamethasone, indomethacin and atenolol. Reductions in hyperalgesia were observed after drug administration ceased, except for the group of animals treated with morphine, in which there was an increase in hyperalgesia after discontinuation of the treatment. Conclusion: Hyperalgesia induced by NP contact with the DRG can be reduced through administration of anti-inflammatory and analgesic drugs, but a greater reduction was observed with the administration of dexamethasone.

show abstract

Modelo experimental para o estudo da hérnia do disco intervertebral

Cited by 4 publications

References 28 publications

Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee

Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee

Comparação da flexibilidade, intensidade da dor e funcionalidade de portadores de hérnia discal submetidos à hidrocinesioterapia versus cinesioterapia clássica

Pharmacologic Treatment of Hyperalgesia Experimentally Induced by Nucleus Pulposus

Contact Info

Product

Resources

About