Efeitos da suplementação oral de L-carnitina associada ao treinamento físico na tolerância ao exercício de pacientes com doença pulmonar obstrutiva crônica

Silva, Audrey Borghi; Lorenzo, Valéria Amorim Pires Di; Jamami, Maurí­cio; Sampaio, Luciana Maria Malosá; Demonte, Aureluce; Cardello, Leonardo; Costa, Dirceu

doi:10.1590/s0102-35862003000600010

Cited by 7 publications

(7 citation statements)

References 24 publications

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“…In a previous study (33), we observed a significant increase of exercise tolerance in the SMWT in patients with mild to moderate COPD receiving L-carnitine supplementation associated with physical exercise. The increased performance of these patients was not associated with an increase of plasma free L-carnitine levels.…”

Section: Discussionmentioning

confidence: 68%

L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs

Borghi‐Silva

Baldissera

Sampaio

et al. 2006

Braz J Med Biol Res

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The effects of adding L-carnitine to a whole-body and respiratory training program were determined in moderate-to-severe chronic obstructive pulmonary disease (COPD) patients. Sixteen COPD patients (66 ± 7 years) were randomly assigned to L-carnitine (CG) or placebo group (PG) that received either L-carnitine or saline solution (2 g/day, orally) for 6 weeks (forced expiratory volume on first second was 38 ± 16 and 36 ± 12%, respectively). Both groups participated in three weekly 30-min treadmill and threshold inspiratory muscle training sessions, with 3 sets of 10 loaded inspirations (40%) at maximal inspiratory pressure. Nutritional status, exercise tolerance on a treadmill and six-minute walking test, blood lactate, heart rate, blood pressure, and respiratory muscle strength were determined as baseline and on day 42. Maximal capacity in the incremental exercise test was significantly improved in both groups (P < 0.05). Blood lactate, blood pressure, oxygen saturation, and heart rate at identical exercise levels were lower in CG after training (P < 0.05). Inspiratory muscle strength and walking test tolerance were significantly improved in both groups, but the gains of CG were significantly higher than those of PG (40 ± 14 vs 14 ± 5 cmH 2 O, and 87 ± 30 vs 34 ± 29 m, respectively; P < 0.05). Blood lactate concentration was significantly lower in CG than in PG (1.6 ± 0.7 vs 2.3 ± 0.7 mM, P < 0.05). The present data suggest that carnitine can improve exercise tolerance and inspiratory muscle strength in COPD patients, as well as reduce lactate production.

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Section: Discussionmentioning

confidence: 68%

L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs

Borghi‐Silva

Baldissera

Sampaio

et al. 2006

Braz J Med Biol Res

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“…Os músculos respiratórios são fundamentais na manutenção da mecânica respiratória e, em condições fisiopatológicas, sua força encontra-se alterada resultando em diminuição das pressões respiratórias 23 . A hiperinsuflação dinâmica presente na DPOC também compromete a performance muscular respiratória, modificando a conformação geomé-trica das fibras musculares e reduzindo a curvatura diafragmática 24,25 . Neste estudo, ao avaliarmos as pressões respiratórias máximas, observarmos que o incremento nos valores da PImáx só foi relevante no grupo que realizou treinamento específico para este fim, já na avaliação da PEmáx houve incremento da PEmáx tanto no GTE, quanto no GTMR, fato relevante e que associado a outros fatores já citados pode correlacionar-se com a melhora da capacidade física observada nos voluntários.…”

Section: Discussionunclassified

Suplementação oral de L-carnitina associada ao treinamento físico e muscular respiratório na doença pulmonar obstrutiva crônica: estudo preliminar

Silva

Fernandes²,

Santos³

et al. 2012

Fisioter. Pesqui.

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| To evaluate the effects of oral supplementation of L-carnitine associated with physical and respiratory muscles training in chronic obstructive pulmonary disease (COPD). Participated 14 COPD volunteers (65±10.4 years), divided in group training mat (GTM) and respiratory muscle training group (RMTG). Passed by the six minute walk test (6MWT) and shuttle walk test (SWT), nutritional assessment of body mass index (BMI), dose recommended daily L-carnitine and evaluation of the inspiratory muscle training (IMT) and expiratory muscle training (EMT). They made 30 min walk on a treadmill 3 times/week for 10 weeks, and the RMTG also carried out 10 min with inspiratory muscle training (Threshold® IMT) and 10 min with expiratory muscle training (Threshold® PEP) with 50% of the MIP and MEP adjusted weekly. After 10 weeks, the volunteers were reevaluated. In 6MWT pre and post physical training programs, the variables changed were distance travelled (DT), final cardiac frequency (FCF), final systolic blood pressure (FSBP), diastolic blood pressure (DBP) and final Borg in RMTG. At GTM the variables changed were initial CF, final CF, SBP final, initial Borg and DT. Comparing the groups, we showed that in 6MWT, GTM presented final CF, final DBP and final Borg higher than RMTG in reevaluation. In shuttle walk test, the final SBP and final Borg were higher in GTM, and DT was higher in RMTG. In respiratory evaluation, the MEP was higher in RMTG in reevaluation. The aerobic training and L-carnitine supplementation in COPD patients presented performance optimization, improvement in physical capacity and greater exercise tolerance.

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“…(26) In another study conducted in Brazil, L-carnitine supplementation combined with physical training was evaluated in patients with COPD (FEV 1 < 65% of predicted) for a period of 6 weeks at a dosage of 2 g/day. (27) The authors observed greater attenuation of the heart rate in a supplemented group in relation to an unsupplemented group. In addition, the distance covered in the 6-minute walk test was greater in the group that received supplementation and physical training.…”

Section: L-carnitinementioning

confidence: 93%

Novas terapias ergogênicas no tratamento da doença pulmonar obstrutiva crônica

et al. 2006

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Chronic obstructive pulmonary disease is currently considered a systemic disease, presenting structural and metabolic alterations that can lead to skeletal muscle dysfunction. This negatively affects the performance of respiratory and peripheral muscles, functional capacity, health-related quality of life and even survival. The decision to prescribe ergogenic aids for patients with chronic obstructive pulmonary disease is based on the fact that these drugs can avert or minimize catabolism and stimulate protein synthesis, thereby reducing the loss of muscle mass and increasing exercise tolerance. This review summarizes the available data regarding the use of anabolic steroids, creatine, L-carnitine, branched-chain amino acids and growth hormones in patients with chronic obstructive pulmonary disease. The advantage of using these ergogenic aids appears to lie in increasing lean muscle mass and inducing bioenergetic modifications. Within this context, most of the data collected deals with anabolic steroids. However, to date, the clinical benefits in terms of increased exercise tolerance and muscle strength, as well as in terms of the effect on morbidity and mortality, have not been consistently demonstrated. Dietary supplementation with substances of ergogenic potential might prove to be a valid adjuvant therapy for treating patients with advanced chronic obstructive pulmonary disease, especially those presenting loss of muscle mass or peripheral muscle weakness.

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Efeitos da suplementação oral de L-carnitina associada ao treinamento físico na tolerância ao exercício de pacientes com doença pulmonar obstrutiva crônica

Cited by 7 publications

References 24 publications

L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs

L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs

Suplementação oral de L-carnitina associada ao treinamento físico e muscular respiratório na doença pulmonar obstrutiva crônica: estudo preliminar

Novas terapias ergogênicas no tratamento da doença pulmonar obstrutiva crônica

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