Linear growth in asthmatic children

Antônio, Maria Ângela Reis de Góes Monteiro; Ribeiro, José Dirceu; Toro, Adyléia Aparecida Dalbo Contrera; Piedrabuena, Aquiles Eugênico; Morcillo, André Moreno

doi:10.1590/s0102-35862003000100008

Cited by 4 publications

(1 citation statement)

References 75 publications

(83 reference statements)

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“…3 O início precoce, o tempo e a gravidade da asma, a deformidade torácica, a hipoxemia, a anorexia crônica, o uso de corticosteróides e o nível socioeconômico são aspectos estudados como potencialmente responsáveis pelo retardo do crescimento desta criança, apesar de resultados conflitantes. 4 Acredita-se que a epilepsia refratária, assim como a asma grave, poderia apresentar diversas repercussões na vida das crianças e seus familiares, levando a restrições nos aspectos físicos, sociais e psicológicos dos envolvidos, podendo aumentar o risco de desenvolvimento de desajustes psicossociais.…”

Section: Introductionunclassified

Percepção do estigma na criança com epilepsia refratária: estudo comparativo entre doenças crônicas na infância

Schlindwein-Zanini¹,

Portuguez

Costa

et al. 2008

J. epilepsy clin. neurophysiol.

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A epilepsia refratária gera impacto na integração social, tendo repercussões emocionais e neuropsicológicas, possibilitando a vivência do estigma pelo paciente e seus familiares. Objetivo: Avaliar a percepção do estigma em crianças com epilepsia refratária e asma grave e em seus respectivos cuidadores, correlacionando os resultados entre estas duas doenças crônicas. Verificar as possíveis diferenças na percepção do estigma entre estes dois grupos de crianças. Métodos: Estudo hipotético-dedutivo-observacional-transversal. A amostra foi constituída de crianças com epilepsia refratária (e seus cuidadores) e do grupo controle constituído por crianças com asma grave (e seus respectivos cuidadores). As avaliações foram realizadas a partir de Escalas de Estigma (Child stigma scale e Parent stigma scale) e Escalas Weschsler de inteligência (WISC III -versão para crianças e WAIS III -versão para adultos) (em critérios de exclusão). Resultados: A análise de variância mostrou que a percepção do estigma é semelhante em ambas doenças, com médias de 22,35 nas crianças com epilepsia e 20,84 naquelas com asma. A maioria das crianças apresentou pontuação na escala de estigma, entre valores médios e altos, sugerindo que a percepção do estigma é significativa. Enquanto que os cuidadores de crianças com epilepsia mostraram média 15,35 e aqueles que cuidam de crianças com asma apresentaram média 15,16, indicando igual vivência de estigma entre os cuidadores.Unitermos: Epilepsia, estigma, asma, cuidador, criança. ABSTRACT Stigma perception on children with refractory epilepsy: Comparative study between chronic diseases in the childhoodThe refractory epilepsy causes an impact in the social integration, emotional and neuropsychological repercussions, which make living with the stigma possible by the patient and the patient's family. Objective: To evaluate the stigma perception on children who suffer from refractory epilepsy and the severe asthma and also on their caregivers, correlating the results between these two chronic diseases. To check the possible differences in the perception of the stigma between these two groups of children. Methods: Hypothetical-deductive-observational-transversal research. The sample was done with children who suffer from refractory

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Section: Introductionunclassified

Percepção do estigma na criança com epilepsia refratária: estudo comparativo entre doenças crônicas na infância

Schlindwein-Zanini¹,

Portuguez

Costa

et al. 2008

J. epilepsy clin. neurophysiol.

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Inhaled corticosteroid treatment and growth of asthmatic children seen at outpatient clinics

Arend¹,

Fischer²,

Debiasi³

et al. 2006

J Pediatr (Rio J)

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Exploring the Genetic Correlation Between Growth and Immunity Based on Summary Statistics of Genome-Wide Association Studies

Zhang

et al. 2018

Front. Genet.

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The relationship between growth and immune phenotypes has been presented in the context of physiology and energy allocation theory, but has rarely been explained genetically in humans. As more summary statistics of genome-wide association studies (GWAS) become available, it is increasingly possible to explore the genetic relationship between traits at the level of genome-wide summary statistics. In this study, publicly available summary statistics of growth and immune related traits were used to evaluate the genetic correlation coefficients between immune and growth traits, as well as the cause and effect relationship between them. In addition, pleiotropic variants and KEGG pathways were identified. As a result, we found negative correlations between birthweight and immune cell count phenotypes, a positive correlation between childhood head circumference and eosinophil counts (EO), and positive or negative correlations between childhood body mass index and immune phenotypes. Statistically significant negative effects of immune cell count phenotypes on human height, and a slight but significant negative influence of human height on allergic disease were also observed. A total of 98 genomic regions were identified as containing variants potentially related to both immunity and growth. Some variants, such as rs3184504 located in SH2B3, rs13107325 in SLC39A8, and rs1260326 located in GCKR, which have been identified to be pleiotropic SNPs among other traits, were found to also be related to growth and immune traits in this study. Meanwhile, the most frequent overlapping KEGG pathways between growth and immune phenotypes were autoimmune related pathways. Pleiotropic pathways such as the adipocytokine signaling pathway and JAK-STAT signaling pathway were also identified to be significant. The results of this study indicate the complex genetic relationship between growth and immune phenotypes, and reveal the genetic background of their correlation in the context of pleiotropy.

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Linear growth in asthmatic children

Cited by 4 publications

References 75 publications

Percepção do estigma na criança com epilepsia refratária: estudo comparativo entre doenças crônicas na infância

Percepção do estigma na criança com epilepsia refratária: estudo comparativo entre doenças crônicas na infância

Inhaled corticosteroid treatment and growth of asthmatic children seen at outpatient clinics

Exploring the Genetic Correlation Between Growth and Immunity Based on Summary Statistics of Genome-Wide Association Studies

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