Réplica

Acid catalysed degradation of some spiramycin derivatives found in the antibiotic bitespiramycin

“…Spiramycin is a 16-member macrolide antibiotic used to treat infections of the oropharynx, respiratory system and genito-urinary tract as well as cryptosporidiosis and toxoplasmosis [1][2][3]. The drug is actually a mixture of spiramycin I together with its 3-acetyl (spiramycin II) and 3-propanoyl (spiramycin III) esters ( Table 1).…”