Pesticide exposure and poor pregnancy outcomes: weaknesses of the evidence

Paumgartten, Francisco José Roma

doi:10.1590/s0102-311x2012001000019

Cited by 1 publication

(1 citation statement)

References 5 publications

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“…Arbuckle et al (2001) observed that the wives of male pesticide applicators have an increased risk of spontaneous abortion when the husband has been exposed to herbicides such as phenoxy acetic acids, triazines, glyphosate, and captan, as well as to insecticides as organophosphorus and carbamates, some of which are also used by the agricultural workers in the three sites of Guerrero state. Reports have also described that pesticides can affect the male reproductive system (Tas et al 1996) and that male exposure may cause a variety of adverse consequences in the offspring of unexposed females (Petrelli et al 2000), a lack of fertility (Koifman et al 2002), and congenital malformations . It is advisable that further epidemiologic research be made on the reproductive toxicity of pesticide use in this region.…”

Section: Arceliamentioning

confidence: 99%

Biomonitoring of agricultural workers exposed to pesticide mixtures in Guerrero state, Mexico, with comet assay and micronucleus test

Carbajal-López

Gómez‐Arroyo

Villalobos‐Pietrini

et al. 2015

Environ Sci Pollut Res

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The aim of this study was to evaluate the genotoxic effect of pesticides in exfoliated buccal cells of workers occupationally exposed in Guerrero, Mexico, using the comet assay and the micronucleus test. The study compared 111 agricultural workers in three rural communities (Arcelia 62, Ajuchitlan 13, and Tlapehuala 36), with 60 non-exposed individuals. All the participants were males. The presence of DNA damage was investigated in the exfoliated buccal cells of study participants with the comet assay and the micronucleus (MN) test; comet tail length was evaluated in 100 nuclei and 3000 epithelial cells of each individual, respectively; other nuclear anomalies such as nuclear buds, karyolysis, karyorrhexis, and binucleate cells were also evaluated. Study results revealed that the tail migration of DNA and the frequency of MN increased significantly in the exposed group, which also showed nuclear anomalies associated with cytotoxic or genotoxic effect. No positive correlation was noted between exposure time and tail length and micronuclei frequencies. No significant effect on genetic damage was observed as a result of age, smoking, and alcohol consumption. The MN and comet assay in exfoliated buccal cells are useful and minimally invasive methods for monitoring genetic damage in individuals exposed to pesticides. This study provided valuable data for establishing the possible risk to human health associated with pesticide exposure.

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