Evaluation of pregnancy as a risk factor in the outcomes of influenza A (H1N1)/2009 in women of childbearing age

Lenzi, Luana; Pontarolo, Roberto

doi:10.1590/s0102-311x2012000200018

Cited by 10 publications

(7 citation statements)

References 6 publications

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“…The use of an antiviral medication was a protective factor death when administered within 72 hours of symptom onset. Several studies have shown an increased risk of death or worsening disease in pregnant women who started treatment late [ 10 , 11 , 19 , 20 , 21 , 22 , 23 ] and in patients in general [ 17 , 18 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009

et al. 2018

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To investigate the factors associated with death and describe the gestational outcomes in pregnant women with influenza A(H1N1)pdm09, we conducted a case-control study (deaths and recovered) in hospitalized pregnant women with laboratory-confirmed influenza A(H1N1)pdm09 with severe acute respiratory illness (SARI) in the state of São Paulo from June 9 to December 1, 2009. All cases were evaluated, and four controls that were matched by the epidemiological week of hospitalization of the case were randomly selected for each case. Cases and controls were selected from the National Disease Notification System-SINAN Influenza-web. The hospital records from 126 hospitals were evaluated, and home interviews were conducted using standardized forms. A total of 48 cases and 185 controls were investigated. Having had a previous health visit to a healthcare provider for an influenza episode before hospital admission was a risk factor for death (adjusted OR (ORadj) of 7.93, 95% CI 2.19–28.69). Although not significant in the multiple analysis (ORadj of 2.13, 95% CI 0.91–5.00), the 3rd trimester deserves attention, with an OR = 2.22, 95% CI 1.13–4.37 in the univariate analysis. Antiviral treatment was a protective factor when administered within 48 hours of symptom onset (ORadj = 0.16, 95% CI 0.05–0.50) and from 48 to 72 hours (ORadj = 0.09, 95% CI 0.01–0.87). There was a higher proportion of fetal deaths and preterm births among cases (p = 0.001) and live births with low weight (p = 0.019), compared to control subjects who gave birth during hospitalization. After discharge, control subjects had a favorable neonatal outcome. Early antiviral treatment during the presence of a flu-like illness is an important factor in reducing mortality from influenza in pregnant women and unfavorable neonatal outcomes. It is important to monitor pregnant women, particularly in the 3rd trimester of gestation, with influenza illness for diagnosis and early treatment.

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Section: Discussionmentioning

confidence: 99%

Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009

et al. 2018

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“…A taxa de letalidade encontrada em nosso estudo é se-melhante àquela observada em outros estudos publicados 19,26,28,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66 .…”

Section: Discussionunclassified

Relacionamento entre bases de dados para vigilância da pandemia de influenza A(H1N1)pdm09, Brasil, 2009-2010

Rossetto

Luna

2016

Cad. Saúde Pública

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Resumo: O objetivo deste estudo foi o de descrever, com base no relacionamento entre os sistemas de informação SINAN (Sistema de Informação de Agravos de Notificação) e SIM (Sistema de Informações sobre Mortalidade), o perfil epidemiológico dos casos notificados de influenza por novo subtipo viral que evoluíram para óbito, durante a pandemia da doença. Foram utilizados dados secundários de ambos os sistemas referentes aos anos de 2009 e 2010. O relacionamento identificou 5.973 óbitos de casos notificados como influenza pandêmica. Destes, 2.170 (36,33%) haviam sido classificados no SINAN como confirmados para a enfermidade; 215 (3,6%), como infecção por outro agente infeccioso; e 3.340 (55,92%), como descartados. Após o relacionamento, alguns casos, que, no SINAN, foram encerrados com evolução para óbito por influenza (n = 658) ou óbito por outras causas (n = 847), não foram encontrados no SIM. O relacionamento entre os bancos de dados pode aprimorar o sistema de vigilância e o dimensionamento da morbimortalidade. Recomendamos o fortalecimento da vigilância da influenza no país com o uso do relacionamento entre os sistemas de informação do Ministério da Saúde.

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“…Some studies [4], [5], [10], [11] found pregnant women might be at increased risk for complications from 2009 influenza A (H1N1) virus infection, and World Health Organization was with the same view on it [14]. But Lenzi found that pregnancy was not associated with increased risk for death in 2009 influenza A (H1N1) infection [15]. This study also showed that pregnancy was not a risk factor for severe cases of 2009 influenza A (H1N1), and this result is critically significant for determining whether pregnant women is at increased risk for severe cases of 2009 influenza A (H1N1).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Severe Cases of 2009 Influenza A (H1N1): A Case Control Study in Zhejiang Province, China

Fang

Lin²,

Chai³

et al. 2012

PLoS ONE

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Few case control studies were conducted to explore risk factors for severe cases of 2009 influenza A (H1N1) with the mild cases as controls. Mild and severe cases of 2009 influenza A (H1N1), 230 cases each, were randomly selected from nine cities in Zhejiang Province, China, and unmatched case control study was conducted. This study found that it averagely took 5 days for the severe cases of 2009 influenza A (H1N1) to start antiviral therapy away from onset, 2 days later than mild cases. Having chronic underlying diseases and bad psychological health combined with chronic underlying diseases were two important risk factors for severe cases, and their OR values were 2.39 and 5.85 respectively. Timely anti-viral therapy was a protective factor for severe cases (OR = 0.35, 95% CI: [0.18–0.67]). In conclusion, psychological health education and intervention, as well as timely anti-viral therapy, could not be ignored in the prevention, control and treatment of 2009 influenza A (H1N1).

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Evaluation of pregnancy as a risk factor in the outcomes of influenza A (H1N1)/2009 in women of childbearing age

Cited by 10 publications

References 6 publications

Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009

Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009

Relacionamento entre bases de dados para vigilância da pandemia de influenza A(H1N1)pdm09, Brasil, 2009-2010

Risk Factors for Severe Cases of 2009 Influenza A (H1N1): A Case Control Study in Zhejiang Province, China

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