Dyslipidemia and the risk of incident hypertension in a population of community-dwelling Brazilian elderly: the Bambuí cohort study of aging

Freitas, Marco Polo Dias; Filho, Antônio Ignácio de Loyola; Lima‐Costa, Maria Fernanda

doi:10.1590/s0102-311x2011001500005

Cited by 13 publications

(14 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for medications for the alimentary tract and metabolism, there was an increase of 2.6 times in the prevalence of drugs used in diabetes, which is consistent with the increase in the prevalence of diabetes mellitus among the older elderly in the Bambuí cohort 34 . Meanwhile, there was a decrease in the use of vitamins in the more recent cohort as compared to the earlier.…”

Section: Discussionsupporting

confidence: 71%

Birth cohort differences in the use of medications in a Brazilian population of older elderly: the Bambuí cohort study of aging (1997 and 2008)

et al. 2011

Self Cite

View full text Add to dashboard Cite

This study examined differences in the use of medications in two birth cohorts (born from 1916 to 1926 and from 1927 to 1937) wave, in 2008 (n = 620). The number of medications currently consumed (mean = 4.6 and 3.4, respectively) and prevalence of polypharmacy (46.6% and 29.1%, respectively) The high prevalence of chronic illnesses among the elderly is associated with high consumption of medications by this population group 3 . In the elderly population, the risks associated with consumption of medications compete with the expected benefits, due to the physiological changes proper to aging, including the decrease in muscle mass and body water, with effects on the pharmacodynamics and pharmacokinetics of medications. Thus, unwanted effects (adverse effects and drug-drug interactions) are more likely to occur 4 .The prevalence of polypharmacy is high in the elderly 5,6,7 , and is one of the strongest predictors of health problems associated with use of medications 4 . Polypharmacy is defined as the use of multiple medications, a basically quantita-ARTIGO ARTICLE Loyola Filho AI et al.

show abstract

Section: Discussionsupporting

confidence: 71%

Birth cohort differences in the use of medications in a Brazilian population of older elderly: the Bambuí cohort study of aging (1997 and 2008)

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…Due to its complex and multifactorial nature, the prevention of dyslipidemia must refer to multiple risk factors. Evidence showed that some predictors are associated with the occurrence of dyslipidemia [7]. Factors related to diet, lifestyle and family history might be associated with an increased risk of dyslipidemia [8], [9].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of a Simple and Effective Prediction Approach for Identifying Those at High Risk of Dyslipidemia in Rural Adult Residents

Wang

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

BackgroundDyslipidemia is an extremely prevalent but preventable risk factor for cardiovascular disease. However, many dyslipidemia patients remain undetected in resource limited settings. The study was performed to develop and evaluate a simple and effective prediction approach without biochemical parameters to identify those at high risk of dyslipidemia in rural adult population.MethodsDemographic, dietary and lifestyle, and anthropometric data were collected by a cross-sectional survey from 8,914 participants living in rural areas aged 35–78 years. There were 6,686 participants randomly selected into a training group for constructing the artificial neural network (ANN) and logistic regression (LR) prediction models. The remaining 2,228 participants were assigned to a validation group for performance comparisons of ANN and LR models. The predictors of dyslipidemia risk were identified from the training group using multivariate logistic regression analysis. Predictive performance was evaluated by receiver operating characteristic (ROC) curve.ResultsSome risk factors were significantly associated with dyslipidemia, including age, gender, educational level, smoking, high-fat diet, vegetable and fruit intake, family history, physical activity, and central obesity. For the ANN model, the sensitivity, specificity, positive and negative likelihood ratio, positive and negative predictive values were 90.41%, 76.66%, 3.87, 0.13, 76.33%, and 90.58%, respectively, while LR model were only 57.37%, 70.91%, 1.97, 0.60, 62.09%, and 66.73%, respectively. The area under the ROC cure (AUC) value of the ANN model was 0.86±0.01, showing more accurate overall performance than traditional LR model (AUC = 0.68±0.01, P<0.001).ConclusionThe ANN model is a simple and effective prediction approach to identify those at high risk of dyslipidemia, and it can be used to screen undiagnosed dyslipidemia patients in rural adult population. Further work is planned to confirm these results by incorporating multi-center and longer follow-up data.

show abstract

“…HDL-C level has been shown to be an independent factor and to be inversely associated with incident hypertension. 6,7,[26][27][28] A study with 15 000 subjects showed that lower level of HDL-C appears to precede the development of hypertension by at least 3 years. 28…”

Section: Discussionmentioning

confidence: 99%

The polymorphic CAG repeat in exon 1 of androgen receptor is associated with level of HDL cholesterol and hypertension in Chinese middle‐aged and elderly men

Yang

Tian

Zhang

et al. 2017

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

Dyslipidemia and the risk of incident hypertension in a population of community-dwelling Brazilian elderly: the Bambuí cohort study of aging

Abstract: (RR = 0.54;). Other lipid parameters had no significant effect on the outcome. High HDL-cholesterol showed an independent protective effect on subsequent development of hypertension in the elderly.

Cited by 13 publications

References 43 publications

Birth cohort differences in the use of medications in a Brazilian population of older elderly: the Bambuí cohort study of aging (1997 and 2008)

Birth cohort differences in the use of medications in a Brazilian population of older elderly: the Bambuí cohort study of aging (1997 and 2008)

Development and Evaluation of a Simple and Effective Prediction Approach for Identifying Those at High Risk of Dyslipidemia in Rural Adult Residents

The polymorphic CAG repeat in exon 1 of androgen receptor is associated with level of HDL cholesterol and hypertension in Chinese middle‐aged and elderly men

Contact Info

Product

Resources

About