Uso do chumbo em urina como indicador de exposição e sua relação com chumbo no sangue

Moreira, Martha Cristina Nunes; Neves, Eduardo Borba

doi:10.1590/s0102-311x2008000900021

Cited by 22 publications

(16 citation statements)

References 21 publications

(47 reference statements)

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“…In addition, metals concentrations in different media have been shown to be differentially mediated by age and sex (Adams and Newcomb, 2014). Metals detected in both blood and urine are reported as independent due to their uncorrelated nature in both media (Adams and Newcomb, 2014; Gulson et al, 1998; Moreira and Neves, 2008). Similarly, total arsenic and arsenic metabolites are reported as independently detected because arsenic metabolites were not consistently detected in study participants, and to maintain consistency with the NHANES panel.…”

Section: Methodsmentioning

confidence: 99%

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Rosofsky

Janulewicz

Thayer

et al. 2017

Environmental Research

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Background Current exposure assessment research does not sufficiently address multi-pollutant exposure and their correlations in human media. Understanding the extent of chemical exposure in reproductive-aged women is of particular concern due to the potential for in utero exposure and fetal susceptibility. Objectives The objectives of this study were to characterize concentrations of chemical biomarkers during preconception and examine correlations between and within chemical classes. Methods We examined concentrations of 135 biomarkers from 16 chemical classes in blood and urine from 73 women aged 18–40 enrolled in Snart Foraeldre/Milieu, a prospective cohort study of pregnancy planners in Denmark (2011–2014). We compared biomarker concentrations with United States similarly-aged, non-pregnant women who participated in the National Health and Nutrition Environmental Survey (NHANES) and with other international biomonitoring studies. We performed principal component analysis to examine biomarker correlations. Results The mean number of biomarkers detected in the population was 92 (range: 60–108). The most commonly detected chemical classes were phthalates, metals, phytoestrogens and polycyclic aromatic hydrocarbons. Except blood mercury, urinary barium and enterolactone, geometric means were higher in women from NHANES. Chemical classes measured in urine generally did not load on a single component, suggesting high between-class correlation among urinary biomarkers, while there is high within-class correlation for biomarkers measured in serum and blood. Conclusions We identified ubiquitous exposure to multiple chemical classes in reproductive-aged Danish women, supporting the need for more research on chemical mixtures during preconception and early pregnancy. Inter- and intra-class correlation between measured biomarkers may reflect common exposure sources, specific lifestyle factors or shared metabolism pathways.

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Section: Methodsmentioning

confidence: 99%

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Rosofsky

Janulewicz

Thayer

et al. 2017

Environmental Research

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“…Several attempts were made to use urinary Pb as a surrogate of blood Pb levels [16, 108], but caution is advised: i) urinary Pb concentration exhibits relatively high intra-individual variability even at similar concentrations of Pb in the blood [16, 109]; ii) estimation of Pb in blood from urinary Pb may be possible on a group basis, but has limited value on an individual basis [108]; iii) for low level exposures urinary Pb levels are close to the detection limit of the analytical methods; iv) Pb urinary excretion reflects mainly recent exposure; and v) the determination of Pb in urine is further complicated by altered kidney function, in association with the nephrotoxic Pb effects [16]. …”

Section: Biomarkers For Lead (Pb) Arsenic (As) and Manganese (Mn)mentioning

confidence: 99%

Lead, Arsenic, and Manganese Metal Mixture Exposures: Focus on Biomarkers of Effect

Andrade

Mateus

Batoréu

et al. 2015

Biol Trace Elem Res

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Summary The increasing exposure of human populations to excessive levels of metals continues to represent a matter of public health concern. Several biomarkers have been studied and proposed for the detection of adverse health effects induced by lead (Pb), arsenic (As) and manganese (Mn); however, these studies have relied on exposures to each single metal, which fails to replicate real-life exposure scenarios. These 3 metals are commonly detected in different environmental, occupational and food contexts and they share common neurotoxic effects, which are progressive and once clinically apparent may be irreversible. Thus, chronic exposure to low levels of a mixture of these metals represents an additive risk of toxicity. Building upon their shared mechanisms of toxicity, such as oxidative stress, interference with neurotransmitters and effects on hematopoietic system, we address putative biomarkers, which may be assist in assessing onset of neurological diseases associated with exposure to this metal mixture.

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“…PbB levels between 5 and 10µg dL -1 suggest the existence of some type of environmental exposure 32 . Based on this, nine individuals in the study were exposed to low Pb levels, i.e., 7.57% of the study population showed environmental contamination with Pb.…”

Section: Pbb (μG DLmentioning

confidence: 99%

Avaliação dos níveis de chumbo e mercúrio em população exposta ambientalmente na Região Centro-oeste do Brasil

et al. 2018

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The objective was to assess the level of exposure to lead and mercury in a population in the Pantanal region in Mato Grosso State, Brazil. Blood lead (PbB) (n = 119) and urinary mercury (HgU) (n = 109) in local residents were measured by atomic absorption spectrometry. Comparison of means and correlations between variables used analysis of variance (ANOVA) and linear regression, respectively, with 95% confidence intervals. Mean PbB was 2.82 ± 1.53µg dL-1. The comparison of PbB stratified by collection site (p ≤ 0.01), work activity (p ≤ 0.01), and consumption of locally produced cow's milk (p ≤ 0.05) showed statistically significant differences. There were also positive associations between PbB and collection site (p ≤ 0.01), participants' profession (p ≤ 0.05), local milk (p ≤ 0.01), and source of drinking water (p ≤ 0.01). Mean HgU was 1.41 ± 0.98µg L-1. The levels only showed significant differences for participants' profession (p ≤ 0.01), and positive associations emerged between HgU and work activity (p ≤ 0.01) and body mass index (p ≤ 0.01). The samples showed low lead and mercury levels, similar to those found in other environmentally exposed populations. Despite these low concentrations, current knowledge on the toxicity of these metals shows that health effects can already be felt at levels that were previously considered safe, thus characterizing a health hazard.

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Uso do chumbo em urina como indicador de exposição e sua relação com chumbo no sangue

Cited by 22 publications

References 21 publications

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Lead, Arsenic, and Manganese Metal Mixture Exposures: Focus on Biomarkers of Effect

Avaliação dos níveis de chumbo e mercúrio em população exposta ambientalmente na Região Centro-oeste do Brasil

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