Rapid tests for diagnosing syphilis: validation in an STD clinic in the Amazon Region, Brazil

Benzaken, Adèle Schwartz; García, Enrique Galbán; Sardinha, José Carlos; Dutra, João Catarino; Peeling, Rosanna W.

doi:10.1590/s0102-311x2007001500013

Cited by 18 publications

(20 citation statements)

References 9 publications

(9 reference statements)

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“…Several studies have different specificity and sensitivity values with the SD Bioline Syphilis 3.0 test. Sensitivity values very close to those found in the present study were reported by Herring et al 23 who found 95.0%; Benzaken et al 26 90.2%; Dlamini et al 27 90.1%; Causer et al 21 87.8%; Bocoum et al 28 90%; and Mehra et al 29 92.9%. As for specificity values, the same authors found 94.9%, 99.4%, 98.0%, 98.5%, 98.0% and 98.3%, respectively.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels

et al. 2017

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Objectives In 2012, the WHO estimated that 6 million new cases of syphilis per year would occur worldwide, including 937 000 in Brazil. Early diagnosis and treatment of syphilis are essential to reduce morbidity and prevent transmission. The availability of rapid tests (RTs) for this diagnosis means that testing can be performed more quickly, as a point-of-care test, even in non-laboratory environments and requires only simple technical training to antibodies detection. The objective of this study was to evaluate the performance and operational aspects of seven commercially available RTs for syphilis in Brazil. Methods Seven rapid treponemal tests were evaluated for sensitivity, specificity, accuracy and Kappa value, according to a panel composed of 493 members. The operational performance of the assay was also determined for these tests. results The seven RTs showed sensitivity ranging from 94.5% to 100% when compared with the reference tests and specificity of between 91.5% and 100%. All the RTs evaluated presented good operational performance, and only one failed to present the minimum specificity as defined by Brazil's Ministry of Health. conclusion All the tests presented good operational performance, and the professionals who performed them considered them to be easy to use and interpret. This evaluation is important for making informed choices of tests to be used in the Brazilian Unified Health System. IntrOductIOnSyphilis constitutes a major public health problem. In 2012, the WHO estimated that six million new cases of syphilis per year would occur worldwide.

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Section: Discussionsupporting

confidence: 90%

Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels

et al. 2017

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“…A utilização do teste em maior escala possibilitaria iniciar o tratamento desde o primeiro contato, diminuindo os casos de tratamento tardio ou não tratamento 30 .…”

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Avaliação das ações de prevenção da transmissão vertical do HIV e sífilis em maternidades públicas de quatro municípios do Nordeste brasileiro

et al. 2009

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“…Available evidences in contemporary scientific literatures did show that the burden of syphilis was found to be substantially high among the attendees of STI-clinic worldwide as well as in China. A study conducted at a STI-clinic of Amazon Region of Brazil reported a syphilis prevalence of 9.4% among the participants [7]. Another study conducted in USA reported a sero-positivity of 2.6% among STI-clinic attendees [8].…”

Section: Introductionmentioning

confidence: 99%

Syphilis and Its Correlates among Heterosexual Males Attending Sexually Transmitted Infection Clinics – Observation from a Multicity Cohort in Jiangsu Province, China

Liu

Hao

Jiang³

et al. 2014

PLoS ONE

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ObjectivesTo estimate the prevalence of HIV and syphilis, incidence of syphilis and to identify the correlates of syphilis infection among heterosexual male attendees of sexually transmitted infection (STI) clinics (MSC).MethodsA cohort study of one-year duration was conducted in Yangzhou and Changzhou cities in Jiangsu province of China. The baseline survey commenced in June 2009, recruited 1225 consenting adult MSCs (609 in Yangzhou and 617 in Changzhou) through STI-clinic based convenience sampling.ResultsBaseline HIV and syphilis prevalence were 0.49% and 17.29% respectively. Syphilis incidence rate was 7.22 per 100 person-years (6.53 in Yangzhou and 7.76 in Changzhou) during the 6-month follow-up with retention fractions of 27.38% and 35.15% for Yangzhou and Changzhou respectively. Majority of the participants were middle-aged, high school educated, married, living with partners and non-migrants. Very few subjects reported recent and consistent condom-use with regular partners. Although considerable number of MSCs reported recent sexual exposure with female sex workers (FSW) and non-FSW casual partners, the proportion of reported condom use was very low during those exposures. In multivariate analyses higher age, having recent sex with FSWs and being HIV-positive were associated with higher syphilis sero-positivity while higher education was protective. In bivariate analyses, being married, divorced/widowed, official residency of the study cities and non-use of condom with regular partners predicted higher risk.ConclusionsConsidering the potential bridging role of MSCs between high and low-risk populations, effective intervention strategies among them targeting the correlates of syphilis infection are urgently called for in Jiangsu province of China.

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Rapid tests for diagnosing syphilis: validation in an STD clinic in the Amazon Region, Brazil

Cited by 18 publications

References 9 publications

Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels

Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels

Avaliação das ações de prevenção da transmissão vertical do HIV e sífilis em maternidades públicas de quatro municípios do Nordeste brasileiro

Syphilis and Its Correlates among Heterosexual Males Attending Sexually Transmitted Infection Clinics – Observation from a Multicity Cohort in Jiangsu Province, China

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