Utilization of HIV/AIDS treatment services: comparing injecting drug users and other clients

Melo, Angelita Cristine de; Caiaffa, Waleska Teixeira; César, Cibele Comini; Dantas, Ricardo Vieira; Couttolenc, Bernard F.

doi:10.1590/s0102-311x2006000400019

Cited by 7 publications

(2 citation statements)

References 29 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent small study analyzed data from 170 patients (68 IDU) from Brazil, aiming to compare the utilization of HIV-related healthcare by IDU and other populations 26. According to this study, IDU were less likely to receive ARV prescriptions and requests for CD4 lymphocyte and viral load counts compared to non-IDU.…”

Section: Introductionmentioning

confidence: 99%

Differential Survival Benefit of Universal HAART Access in Brazil: A Nation-Wide Comparison of Injecting Drug Users Versus Men Who Have Sex With Men

Malta

Bastos²,

Silva³

et al. 2009

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

Objective-Brazil accounts for ∼70% of injection drug users (IDU) receiving HAART in low/ middle income countries. We evaluated the impact of HAART availability/access on AIDS-related mortality among IDU versus men who have sex with men (MSM). Design-Nationwide analysis on Brazilian IDU and MSM diagnosed with AIDS in 2000-2006.Methods-Four national information systems were linked and Cox regression was used to assess impact of HAART availability/access on differential AIDS-related mortality.Results-Among 28,426 patients, 6,777 died during 87,792 person-years of follow-up. Compared to MSM, IDU were significantly less likely to be receiving HAART, to have ever had determinations for CD4 or viral load. After controlling for confounders, IDU had a significantly higher risk of death (AHR: 1.94; 95% CI: 1.84-2.05). Among the subset that had at least one CD4 and viral load determination, higher risk of death among IDU persisted (HR: 1.82; 95% CI: 1.58-2.11). Non-white ethnicity significantly increased this risk, while prompt HAART uptake after AIDS diagnosis reduced the risk of death. After controlling for spatially-correlated survival data, AIDS-related mortality remained higher in IDU than in MSM.

show abstract

Section: Introductionmentioning

confidence: 99%

Differential Survival Benefit of Universal HAART Access in Brazil: A Nation-Wide Comparison of Injecting Drug Users Versus Men Who Have Sex With Men

Malta

Bastos²,

Silva³

et al. 2009

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

show abstract

“…The finding of a low prevalence may reflect the fact that, although ART has been scaled-up in the city, the number of patients receiving ART in Hanoi may not be high enough to generate and transmit resistant mutations. Moreover, most HIV infections are in IDUs, who tend to have poor access to healthcare, including ARVs; therefore, drug-resistant mutations might be less likely to emerge, and be transmitted within this group [11,12].…”

Section: Overall Results and Interpretation Of Drug Mutationsmentioning

confidence: 99%

HIV drug resistance threshold survey using specimens from voluntary counselling and testing sites in Hanoi, Vietnam

Nguyen

Duc²,

Shrivastava³

et al. 2008

Antiviral Therapy

View full text Add to dashboard Cite

Background In countries where antiretroviral therapy has been available or is being rapidly expanded, the World Health Organization (WHO) recommends surveillance for transmitted HIV drug resistance (HIVDR) by threshold surveillance methods using specimens from antenatal clinics or voluntary counselling and testing (VCT) sites. The aim of this study was to implement the HIVDR threshold survey in VCT sites in Vietnam, where HIV prevalence is high. Estimating transmitted resistance in the infected population will enable the appropriateness of current antiretroviral drug regimens to be assessed and will inform plans for future HIVDR surveillance. Methods Consecutive blood specimens were collected from 70 newly diagnosed HIV-positive clients 18–24 years of age at two sites in Hanoi, Vietnam. Informed consent and serum specimens were obtained from each eligible client, with serum frozen at -70°C until shipping to Thailand for resistance testing using the TruGene system. Results From February until August 2006, 559 clients were eligible to participate in this survey. Of the 535 clients (95.7%) who agreed to participate, 70 (13%) were HIV-positive and were included in the survey. Of the 70 specimens sent for genotyping, 52 consecutive samples were amplified, 49 of which could be genotyped. Only 1 of 49 genotyped specimens had mutations associated with drug resistance (L74V and Y181C) in the reverse transcriptase gene, indicating that the prevalence of transmitted HIVDR to all drugs and drug classes evaluated was <5%. Conclusion The prevalence of transmitted HIVDR was low in Hanoi as determined using threshold surveillance methods. The Ministry of Health plans to repeat this survey methodology in one more province and to confirm these findings by expanded HIVDR surveillance.

show abstract

Adherence to Antiretroviral Medications Among Persons Who Inject Drugs in Transitional, Low and Middle Income Countries: An International Systematic Review

et al. 2014

View full text Add to dashboard Cite

Adherence to antiretroviral (ART) medication is vital to reducing morbidity and mortality among HIV positive persons. People who inject drugs (PWID) are at high risk for HIV infection in transitional/low/middle income countries (TLMIC). We conducted a systematic review of studies reporting adherence to ARTs among persons with active injection drug use and/or histories of injection drug use in TLMIC. Meta-regression was performed to examine relationships between location, adherence measurements, and follow-up period. Fifteen studies were included from seven countries. Adherence levels ranged from 33% to 97%; mean weighted adherence was 72%. ART adherence was associated with different methods of measuring adherence and studies conducted in Eastern Europe and East Asia. The great heterogeneity observed precludes generalization to TLMIC as a whole. Given the critical importance of ART adherence more research is needed on ART adherence among PWID in TLMIC, including the use of standardized methods for reporting adherence to ARTs.

show abstract

Utilization of HIV/AIDS treatment services: comparing injecting drug users and other clients

Abstract: This study compared healthcare utilization by injection drug users (IDUs)

Cited by 7 publications

References 29 publications

Differential Survival Benefit of Universal HAART Access in Brazil: A Nation-Wide Comparison of Injecting Drug Users Versus Men Who Have Sex With Men

Differential Survival Benefit of Universal HAART Access in Brazil: A Nation-Wide Comparison of Injecting Drug Users Versus Men Who Have Sex With Men

HIV drug resistance threshold survey using specimens from voluntary counselling and testing sites in Hanoi, Vietnam

Adherence to Antiretroviral Medications Among Persons Who Inject Drugs in Transitional, Low and Middle Income Countries: An International Systematic Review

Contact Info

Product

Resources

About