Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility

Hatagima, Ana

doi:10.1590/s0102-311x2002000200002

Cited by 36 publications

(29 citation statements)

References 114 publications

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“…31 Glutathione S-transferase (GST) family includes no fewer than four classes of genes: GSTalpha, mu (GSTM), pi (GSTP), and theta (GSTT), the alleles of which have been frequently associated with some types of tumors. 1 Studies of GST genes polymorphisms and lung cancer have found associations lower than three, 9 ranging from OR 0.8 24 to OR 2.7. 13 A meta-analysis of combined results of studies with GST genes revealed a tenuous risk, OR 1.14 (95% CI: 1.03-1.25).…”

Section: Genetic Polymorphisms and Cancermentioning

confidence: 99%

Modern cancer epidemiological research: genetic polymorphisms and environment

Filho

Zago

2005

Rev. Saúde Pública

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Individual cancer susceptibility seems to be related to factors such as changes in oncogenes and tumor suppressor genes expression, and differences in the action of metabolic enzymes and DNA repair regulated by specific genes. Epidemiological studies on genetic polymorphisms of human xenobiotics metabolizing enzymes and cancer have revealed low relative risks. Research considering genetic polymorphisms prevalence jointly with environmental exposures could be relevant for a better understanding of cancer etiology and the mechanisms of carcinogenesis and also for new insights on cancer prognosis. This study reviews the approaches of molecular epidemiology in cancer research, stressing case-control and cohort designs involving genetic polymorphisms, and factors that could introduce bias and confounding in these studies. Similarly to classical epidemiological research, genetic polymorphisms requires considering aspects of precision and accuracy in the study design. Resumo A suscetibilidade individual ao câncer envolve fatores como mudanças na expressão dos oncogenes e genes supressores de tumores e, também, diferenças em genes específicos que regulam a ação de enzimas metabólicas e de reparo do DNA. Estudos epidemiológicos relacionando polimorfismos genéticos e câncer têm mostrado riscos relativos tênues. Pesquisas abordando simultaneamente a prevalência de polimorfismos genéticos e a exposição a fatores ambientais podem conduzir a resultados relevantes para a compreensão da etiologia do câncer e dos

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Section: Genetic Polymorphisms and Cancermentioning

confidence: 99%

Modern cancer epidemiological research: genetic polymorphisms and environment

Filho

Zago

2005

Rev. Saúde Pública

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“…These are widely expressed in mammalian tissues and have broad substrate specificity. GSTs are expressed in all living mammals and constitute more than 4% of the total soluble protein (Hatagima, 2002). Based on similarity of the amino acid sequence, GSTs have been grouped into at least seven classes known as alpha (a), mi (m), pi (p), theta (q), zeta (z), sigma (s), and more recently discovered omega (W) (Coughlin and Hall, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous genetic polymorphisms have been reported for GST enzymes (Hatagima, 2002;Joseph et al, 2006) resulting in a lack of functional protein or causing either increased or decreased metabolic activity (Rubes et al, 2007;Taspinar et al, 2008). Genes encoding the GST Mu-1 and Theta-1 (GSTM1 and GSTT1, respectively) isoforms are polymorphic (Chen et al, 2002;Nakata et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

Finotti

Silva²,

Bordin³

et al. 2009

Genet. Mol. Res.

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ABSTRACT. Male infertility is a heterogeneous disorder, with various genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxifying enzymes of phase II drug metabolism can modify their expression or function, affecting the biotransformation of toxic compounds to which the male reproductive system is exposed. GSTM1 and GSTT1 encode enzymes that are essential in the process of detoxification of endogenous and exogenous xenobiotics, facilitating their excretion. We examined GSTM1 and GSTT1 polymorphism in 233 men with idiopathic infertility seen at the Human Reproduction Service of the Federal University of Goiás from [2004][2005][2006]. Genotype GSTM1/T1 (null) was found in 30/105 normal individuals and in 64/128 abnormal individuals, indicating a significant association with idiopathic male infertility. The sperm alteration associated with greater GSTM1/T1 (null) frequency was decreased sperm count (oligozoospermy), which was more frequent in patients with GSTM1 (78.9%) as well as in those who had GSTT1 (73.7%), although the difference was not significant. Individuals polymorphic for genes GSTM1 and GSTT1 are susceptible to reduction in sperm quality and infertility, possibly because oligozoo-

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“…Some studies indicate that homozygosis for GSTM1 null is associated with the increased risk of various types of cancer: lung, adenocarcinoma and also colorectal and other types of diseases (chronic bronchitis, arteriosclerosis) [34].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of biotransforming enzymes (GSTs) and their association with colorectal cancer in the Slovak population

Matáková¹,

Sivoňová²,

Halašová³

et al. 2009

neo

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The aim of present study was to summarize the results of a case-control study focused on genetic polymorphisms of selected Phase II metabolizing enzymes (GSTM1, T1, P1) and to investigate the association of these polymorphisms with the colorectal cancer risk among the Slovak population.A case-control study with 183 colorectal cancer cases and 422 controls was conducted. DNA was extracted from peripheral blood leukocytes, and the polymorphisms of GSTM1, GSTT1 and GSTP1 enzymes were determined by PCR-based methods. Association between specific genotypes and the development of colorectal cancer were examined using logistic regression analysis to calculate odds ratios (OR) and 95% confidence intervals (CI).The GSTP1 val/val genotype (OR=2.1, 95%CI: 1.1 -4.0, χ 2 = 0.28 and P = 0.0025) was associated with an elevated risk. The statistically significant correlation was found also for the combined genotypes of GSTM1 null and GSTP1 valine homozygosity (OR = 2.7, 95% CI: 1.1-6.1, χ 2 = 4.5 and P = 0.03). The genotype of certain metabolising enzymes affects the risk for colorectal cancer. This effect is also important when certain allelic combinations are studied. In the near future, individual risk assessment may be reached by further increasing the number of studies of polymorphisms, combining them with the traditional epidemiological risk factor.

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Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility

Cited by 36 publications

References 114 publications

Modern cancer epidemiological research: genetic polymorphisms and environment

Modern cancer epidemiological research: genetic polymorphisms and environment

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

Polymorphisms of biotransforming enzymes (GSTs) and their association with colorectal cancer in the Slovak population

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