A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups

Abstract

We conducted a case-control study of the association between SIL and HPV among whites (W ) , African Americans (AA), and Hispanics (H) in Harris County, Tex a s . Cases were identified at M.D. Anderson Cancer Center Colposcopy Clinic. C o n t rols were identified among W and AA, ), re s p e c t i ve l y.Si m i l a rl y, racial/ethnic differences were observed for both LSIL (AOR = 16.6, 7 . 7 , and 4.3, re s p e ct i vely) and HSIL (AOR = 78.6, 3 4 . 6 , and 14.2 AO R : 29,5 (12,5); 15,3 (6,8); e 5,8 (2,[6][7][8][9][10][11][12]6). De forma similar, f o ram observadas diferenças para ambos LSIL (AO R , re s p e c t i va m e n t e , de 16,6; 7,7 e 4,3) e HSIL (AOR de 78,6; 34,6 e 142). Os resultados apóiam a existência de associação entre SIL e H P V, d i f e renças na força de associação com SILs e HSILs, e sugerem risco mais elevado para mul h e res latinas e menor para mulheres negra s . , re s p e c t i ve l y ) . Findings support the association between SIL and HPV and differences in the strength of the association with LSILs and HSILs. Da t a also suggest a higher risk for H and a lower risk for AA. Key words Pa p i l l o m a v i r u s ; Ce rvix Ne o p l a s m s ; Ethnic Gro u p s ; Ca s e -C o n t rol St u d i e s Resumo Foi realizado um estudo caso-controle para analisar a associação entre lesões intraepiteliais escamosas do colo uterino (SIL) e HPV entre mulheres bra n c a s , n e g ras e latinas em Harris County, Tex a s . Os casos foram identificados na M. D. Anderson Cancer Center Colposcopy C l i n i c , e os controles foram obtidos realizando-se exame de Papanicolau em duas clínicas do De p a rtamento de Saúde. O HPV foi detectado por meio de ensaio de PCR (primer MY09/MY11). Fo ram construídos modelos de re g ressão logística para estimar as odds ra t i o s ajustadas (AO R ) , e seus intervalos de confiança de 95% (IC) de SIL entre os grupos étnicos e graus da doença. A prevalência de HPV nas SIL de baixo grau (LSIL) foi de 64%; nas de alto grau (HSIL), 8 4 % ; e 19% nos c o n t ro l e s . O risco de SIL foi maior em mulheres latinas que em brancas e negra s , sendo observad a s , re s p e c t i va m e n t e , as seguintes Palavras-chave Pap il om av ir u s ; Neoplasias do Colo Ut e r i n o ; Grupos Étnicos; Estudos de Casos e C o n t ro l e s

Human Leukocyte Antigen Class II Alleles and Risk of Cervical Cancer in China

“…However, very scant information regarding the extent of HPV infection and associations between HPV, HLA, and cervical cancer in China is available. Ethnic differences for cervical cancer and premalignant lesions have been reported for Latin American and U.S. Hispanics, revealing a higher risk for HPV infection and cervical cancer in those women [38,39]. Reported associations of HLA-and HPV-related cervical cancer in Latin America have dealt with Caucasian, Hispanic, and mestizo women [8,15,40].…”

Human Papillomavirus Genotype Distribution in Low-Grade Cervical Lesions: Comparison by Geographic Region and with Cervical Cancer

“…Each study was classified into one of five regions: Africa, Asia, Europe, North America, or South/Central America. If publications did not present the relevant data but study methods suggested that this information was available, data requests were made to authors (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Detailed information on all included studies is presented in Appendix A.…”

An Examination of Acceptability of HPV Vaccination among African American Women and Latina Immigrants

“…3 Studies have found multiple factors that are associated with such disparities in cervical cancer incidence between African Americans and Latinas and their white counterparts, including income, education, delay in seeking care for symptoms, lower rates of Pap smear, and higher rates of human papillomavirus (HPV) infection. [4][5][6][7][8][9][10][11] HPV has been identified as a necessary cause of nearly all cervical cancers 12,13 ; therefore, citing Rock et al, 12 primary prevention of cervical cancer should focus on risk reduction, dietary changes, and preventive vaccination. Recent studies showed that an HPV16/18 prophylactic vaccine had a great impact on the reduction of HPV16/18 infection and related cervical intraepithelial neoplasia (CIN).…”