Alcohol consumption and gastric cancer in Mexico

López‐Carrillo, Lizbeth; López-Cervantes, Malaquı́as; Ramírez-Espitia, Armando; Rueda, Celina; Fernandez-Ortega, Cielo; Orozco-Rivadeneyra, Sergio

doi:10.1590/s0102-311x1998000700004

Cited by 19 publications

(12 citation statements)

References 8 publications

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“…Fourteen studies examined the association of smoking and gastric cancer [24, 25, 32–36, 40, 42, 49, 58, 59, 62, 66]. Study-specific ORs for ever smokers vs. never smokers ranged from 0.56 to 5.87 (Figure 2b).…”

Section: Resultsmentioning

confidence: 99%

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Risk factors for gastric cancer in Latin America: a meta-analysis

Bonequi

Meneses-González

Correa

et al. 2012

Cancer Causes Control

118

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Background Latin America has among the highest gastric cancer incidence rates in the world, for reasons that are still unknown. In order to identify region-specific risk factors for gastric cancer, we conducted a meta-analysis summarizing published literature. Methods Searches of PubMed and regional databases for relevant studies published up to December 2011 yielded a total of 29 independent case-control studies. We calculated summary odds ratios (OR) for risk factors reported in at least five studies, including socioeconomic status (education), lifestyle habits (smoking and alcohol use), dietary factors (consumption of fruits, total vegetables, green vegetables, chili pepper, total meat, processed meat, red meat, fish and salt) and host genetic variants (IL1B-511T, IL1B-31C, IL1RN*2, TNFA-308A, TP53 codon 72 Arg and GSTM1 null). Study-specific ORs were extracted and summarized using random-effects models. Results Chili pepper was the only region-specific factor reported in at least five studies. Consistent with multifactorial pathogenesis, smoking, alcohol use, high consumption of red meat or processed meat, excessive salt intake and carriage of IL1RN*2 were each associated with a moderate increase in gastric cancer risk. Conversely, higher levels of education, fruit consumption, and total vegetable consumption were each associated with a moderately decreased risk. The other exposures were not significantly associated. No prospective study data were identified. Conclusion Risk factor associations for gastric cancer in Latin America are based on case-control comparisons that have uncertain reliability, particularly with regard to diet; the specific factors identified and their magnitudes of association are largely similar to those globally recognized. Future studies should emphasize prospective data collection and focus on region-specific exposures that may explain high gastric cancer risk.

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Section: Resultsmentioning

confidence: 99%

“…Risk estimates for alcohol use were reported in 16 studies [24, 25, 32–35, 37, 40, 41, 49, 52, 56, 58, 59, 62, 66]. For six of these studies [24, 25, 58, 59, 62, 66], dose-specific ORs for ever drinkers were averaged since overall associations were not reported.…”

Section: Resultsmentioning

confidence: 99%

Risk factors for gastric cancer in Latin America: a meta-analysis

Bonequi

Meneses-González

Correa

et al. 2012

Cancer Causes Control

118

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“…There are mixed findings about the relation between the type of alcoholic beverage and the incidence of gastric cancer. Wine drinking was significantly associated with a risk of developing gastric cancer in a study in Mexico, for the highest category of wine intake Odds ratio (OR) = 2.93 (CI 95%: 1.27–6.75) [34]. In Portugal, consumption of more than one bottle of red wine per day 20 years prior to the interview was also associated with a gastric cancer risk, OR = 2.61 (p = 0.049) [35].…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up

et al. 2012

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BackgroundGastric cancer is the second most common cause of death from cancer in the world. Epidemiological findings on alcohol use in relation to gastric cancer remain controversial. The aim of this study was to examine the effect of alcohol consumption on the risk of gastric cancer.MethodsThe association between alcohol intake and the risk of gastric cancer was examined in a population-based cohort of 7,150 men in Kaunas, Lithuania, who were enrolled during 1972–1974 or 1976–1980. After up to 30 years of follow-up, 185 gastric cancer cases were identified. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). The attained age was used as a time-scale.ResultsAfter adjustment for smoking, education level and body mass index, the HR of gastric cancer was 2.00 (95% CI: 1.04–3.82) for the highest alcohol consumption frequency (2–7 times per week) compared with occasional drinking (a few times per year) and 1.90 (95% CI: 1.13–3.18) for ≥100.0 g ethanol/week versus 0.1–9.9 g ethanol/week. A stronger effect of alcohol consumption on gastric cancer risk was observed during the second half of the study (1993–2008). In the analysis of gastric cancer risk by alcoholic beverage type, all beverages were included simultaneously in the model. The multivariate HR for men who consumed ≥0.5 litre of wine per occasion (compared with those who consumed <0.5 litre) was 2.95 (95% CI: 1.30–6.68). Higher consumption of beer or vodka was not statistically significantly associated with gastric cancer risk. After adjustment for smoking, education level, body mass index and ethanol, we found no excess risk of gastric cancer in association with total acetaldehyde intake.ConclusionsThis study supports a link between alcohol consumption (primarily from ethanol) and the development of gastric cancer in the Lithuanian population. Although an association with heavy wine consumption was observed, the effect of exposure to acetaldehyde on the development of gastric cancer in this cohort was not confirmed. Further research is needed to provide a more detailed evaluation of alcohol drinking and gastric cancer risk.

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“…Risk increases have been demonstrated with alcohol intake, specifically with hard liquor, beer (odds ratio [OR]=2.4; CI 95%, 1.5-3.9) [33], and wine (OR=2.93; CI 95%, 1.27-6.75) [34]. Alcohol intake has also been shown to increase the risk of chronic atrophic gastritis (3.2, 95% CI 1.1-9.2) [35].…”

Section: Alcoholmentioning

confidence: 99%

Nutrition and diet in the development of gastrointestinal cancer

Thomson

LeWinn²,

Newton³

et al. 2003

Curr Oncol Rep

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Diet plays a role in the prevention and development of gastrointestinal cancers. The majority of available research consists of case-control studies, but the number of clinical trials is growing. The dietary recommendations to reduce gastrointestinal cancer risk include lowering total energy, fat, and saturated fat intake; avoidance of grilled and smoked foods; avoidance of alcohol; and increasing intake of fruits, vegetables, and fiber. Studies of esophageal cancer support these dietary approaches, with the exception of dietary fat reduction and increased green tea intake. For gastric cancer, consuming additional fruits and vegetables, including those high in ascorbic acid, may reduce risk, and the capacity for diet to alter Helicobacter pylori infection should be explored. Recent interventional trials do not support a role for high-fiber or low-fat diets in reducing development of colon adenomas, although the evidence does not rule out efficacy at earlier stages of disease. Finally, the evidence for a relationship between pancreatic cancer and diet remains sparse and warrants additional investigation.

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Alcohol consumption and gastric cancer in Mexico

Cited by 19 publications

References 8 publications

Risk factors for gastric cancer in Latin America: a meta-analysis

Risk factors for gastric cancer in Latin America: a meta-analysis

Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up

Nutrition and diet in the development of gastrointestinal cancer

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