Fatores envolvidos na reatividade do PPD em pacientes com doença de Hansen

Duppré, Nádia Cristina; Alvim, Maria Fernanda Sardella; Gallo, Maria Eugênia Noviski; Nery, José Augusto da Costa; Sarno, Euzenir Nunes

doi:10.1590/s0102-311x1990000200006

Cited by 1 publication

(2 citation statements)

References 4 publications

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“…Other retrospective studies on the same cohort as that covered in the present study also revealed variations in the findings regarding the protective effect of BCG [8, 21]. However, the methodological differences (sampling, analysis methods, and follow-up time) of these studies must not be ignored.…”

Section: Discussionmentioning

confidence: 49%

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Kinship and Leprosy in the Contacts of Leprosy Patients: Cohort at the Souza Araújo Outpatient Clinic, Rio de Janeiro, RJ, 1987–2010

Santos

Duppré

Sales

et al. 2013

Journal of Tropical Medicine

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A broad variety of factors have been associated with leprosy among contacts, including socioeconomic, epidemiological, and genetic characteristics. Data from 7,174 contacts of leprosy patients from a leprosy outpatient clinic in Rio de Janeiro, Brazil, 1987–2010, were analyzed to investigate the effects of kinship, individual, and contextual factors on leprosy. Multivariate analyses were performed using a robust estimation method. In the prevalence analysis, close kinship (sibling OR = 2.75, offspring OR = 2.00, and other relatives OR = 1.70), socioeconomic factors, and the duration of exposure to the bacillus were associated to leprosy. In the incidence analysis, significant risks were found for all categories of kinship (parents RR = 10.93, spouse, boyfriend/girlfriend, and bride/groom RR = 7.53, sibling RR = 7.03, offspring RR = 5.34, and other relatives RR = 3.71). Once the treatment of the index case was initiated, other factors lost their significance, and the index case bacteriological index and BCG (Bacillus Calmette-Guérin vaccine) protection had a greater impact. Our findings suggested that both genetic susceptibility and physical exposure play an important role in the epidemiology of leprosy, but it was not possible establishing the role of genetic factor. Analyses of other factors related to the genotype of individuals, such as genetic polymorphisms, are needed.

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Section: Discussionmentioning

confidence: 49%

“…Matos et al (1999) found a protective effect of 62% among household contacts after adjustments via the Mitsuda test and the clinical form of the index case [8]. Duppre et al (1998) showed the protective effect of a childhood BCG scar in the contacts of multibacillary (MB) index cases [21]. …”

Section: Discussionmentioning

confidence: 99%