Primary intraocular chondrosarcoma in a dog

Perlmann, Eduardo; Morales, Adriana; Góes, Ana Carolina Almeida de; Dagli, M.L.; Barros, P S M

doi:10.1590/s0102-09352013000600011

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…The first descriptions of this unique ocular condition were only published several years later . In dogs, ocular chondrosarcoma may be primary or metastatic . Primary ocular chondrosarcoma has also been reported in fish ( Symphysodon aequifasciatus ) …”

Section: Introductionmentioning

confidence: 99%

Presumed post‐traumatic ocular chondrosarcoma with intrathoracic metastases in a cat

Moreira

Andrade

Fulgêncio³

et al. 2017

Veterinary Ophthalmology

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An indoor-only, 5-year-old, spayed female domestic shorthair cat presented for an ophthalmic examination of the left eye. An intraocular tumor with secondary glaucoma and blindness was diagnosed; the globe was enucleated and sent for histopathological examination. Gross examination revealed a solid white mass filling the entire vitreous space and replacing the iris and ciliary body. The lens and retina appeared to be similarly replaced by the neoplasm. Histological examination revealed a complete loss of the internal ocular structures, with a ruptured capsule as the only remnant of the lens within an extensive malignant mesenchymal neoplastic cell proliferation. The cells were polygonal, with well-defined cytoplasmic borders and abundant weakly basophilic cytoplasm, embedded within the islands of chondroid matrix. No neoplastic invasion of the sclera was apparent. The animal died 6 months after the enucleation due to respiratory distress. Gross examination revealed numerous firm, white to tan nodular masses with smooth to mildly irregular surfaces dispersed throughout the parietal pleura, thoracic surface of the diaphragm, tracheobronchial and mediastinal lymph nodes, pericardium, and lungs. On cross-section, the neoplastic nodules were solid and variably translucent, resembling hyaline cartilage. Histologically, these nodules were similar to the neoplasm identified earlier in the left globe. Metastasis of post-traumatic ocular chondrosarcoma has not yet been described in cats. This is therefore believed to be the first report of metastases of this type of neoplasm in cats. This case adds to the limited set of data on the outcome of this type of tumor.

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Section: Introductionmentioning

confidence: 99%

Presumed post‐traumatic ocular chondrosarcoma with intrathoracic metastases in a cat

Moreira

Andrade

Fulgêncio³

et al. 2017

Veterinary Ophthalmology

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“…11 In a case series of 67 cats with chondrosarcomas, 47 were tumors of skeletal origin and 20 presented in subcutaneous sites, several of which were thought to be vaccine-site sarcomas. 4 Intraocular chondrosarcoma is reported in 2 dogs as a primary 9 or metastatic 10 neoplasm. Metastatic intraocular chondrosarcoma was also reported in 1 human patient.…”

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confidence: 99%

Presumed primary intraocular chondrosarcoma in cats

2014

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Following unilateral enucleation, 4 Domestic Shorthair cats with an average age of 12.5 years (range: 9-16 years) were histologically diagnosed with a presumed primary intraocular chondrosarcoma at the Comparative Ocular Pathology Laboratory of Wisconsin (Madison, Wisconsin). Medical records and follow-up were available for 3 of the 4 cats. Clinically, only 1 eye was affected in each cat; a mass lesion was noted in 2 cats, and a neoplasm was suspected in the other 2 cats. Grossly, 3 tumors presented as coalescing, poorly demarcated, white, friable masses filling the vitreous and intraocular chambers; 1 tumor presented as a solitary, well-demarcated, tan mass involving the iris and ciliary body. Histologically, all 4 neoplasms were composed of haphazardly arranged plump neoplastic spindle cells surrounded by irregular islands and thick trabeculae of abundant, variably basophilic, and Alcian blue-positive chondromatous matrix. None of the cats presented histologically or clinically with signs suggestive of feline posttraumatic ocular sarcoma. Two cats are still alive and healthy 6 months and 3 years following enucleation. One cat died 6 months following enucleation; however, this cat suffered from poorly controlled diabetes mellitus, and the cause of death is undetermined. No other tumors or skeletal lesions were identified that could suggest a metastatic tumor to the eye. The origin of primary intraocular chondrosarcoma is unclear, but is presumed to be ocular multipotent mesenchymal stem cells. Four cases of intraocular chondrosarcoma in cats not associated with the posttraumatic sarcoma complex of intraocular tumors are described.

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