Mammary carcinosarcoma in cat: a case report

Paniago, Juliana Del Giúdice; Vieira, Antônio Wilson; Ocarino, Natália de Melo; França, S. A.; Malm, Christina; Cassali, Geovanni Dantas; Serákides, Rogéria

doi:10.1590/s0102-09352010000400008

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…It always shows features of malignancies in both components, and in the dog, it most often presents as a carcinoma and osteosarcoma. 14,31,34,37 In our cases, the 2 cell components were evident, but the interstitial cells morphologically resembled the malignant myoepithelium of canine carcinoma and malignant myoepithelioma. 10,14,31,34,37 The definitive diagnosis was based on the fact that the interstitial cells exclusively expressed vimentin alone or vimentin and SMA.…”

Section: Discussionmentioning

confidence: 48%

“…14,31,34,37 In our cases, the 2 cell components were evident, but the interstitial cells morphologically resembled the malignant myoepithelium of canine carcinoma and malignant myoepithelioma. 10,14,31,34,37 The definitive diagnosis was based on the fact that the interstitial cells exclusively expressed vimentin alone or vimentin and SMA. This is not definitive for the identification of myoepithelial cells, since vimentin and SMA also label mesenchymal cells (ie, myofibroblasts).…”

Section: Discussionmentioning

confidence: 48%

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Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

et al. 2020

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Feline mammary tumors are usually malignant and aggressive carcinomas. Most cases are simple monophasic carcinomas (1 epithelial population), and additional phenotyping is usually not needed. In this study, we describe 10 malignant mammary tumors from 9 female cats that had unusual histomorphology: they appeared biphasic, with 2 distinct cell populations. Initially, they were morphologically diagnosed as either carcinosarcoma (1/10) or malignant pleomorphic tumor (9/10) of the mammary gland, as the latter did not match any previously described histological subtype. Immunohistochemistry (IHC) was performed for pancytokeratin, cytokeratins 8 and 18, cytokeratin 14, cytokeratins 5 and 6, vimentin, p63, calponin, alpha-smooth muscle actin, Ki-67, ERBB2, estrogen receptor alpha, and progesterone receptor. In 7 of 10 cases, the biphasic nature was confirmed and, on the basis of the IHC results, they were classified as carcinoma and malignant myoepithelioma (4/10), ductal carcinoma (1/10), and carcinosarcoma (2/10). The other 3 of 10 cases were monophasic based on IHC. In the cases of carcinoma and malignant myoepithelioma, the malignant myoepithelial cells were 100% positive for vimentin (4/4) and variably positive for p63, calponin, and cytokeratins (4/4). These findings show that, although rare, biphasic mammary carcinomas do occur in cats. In dogs and humans, tumors composed of malignant epithelial and myoepithelial cells have a less aggressive behavior than certain simple carcinomas, and therefore, their identification might also be clinically significant in the cat.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 48%

Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

et al. 2020

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“…Paniago et al . 58 reported a “feline mammary carcinosarcoma” mainly composed of malignant pleomorphic cells, but no spindle cells were described 58 . Similar to the survival of the patient described in this study (three months), the animals reported by Matsuda et al .…”

Section: Discussionmentioning

confidence: 99%

“… 57 and Paniago et al . 58 developed pulmonary metastasis and died three and two months after diagnosis, respectively 57 , 58 .…”

Section: Discussionmentioning

confidence: 99%

TiHo-0906: a new feline mammary cancer cell line with molecular, morphological, and immunocytological characteristics of epithelial to mesenchymal transition

Granados-Soler

Junginger

Hewicker‐Trautwein

et al. 2018

Sci Rep

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Feline mammary carcinomas (FMCs) with anaplastic and malignant spindle cells histologically resemble the human metaplastic breast carcinoma (hMBC), spindle-cell subtype. hMBCs display epithelial-to-mesenchymal transition (EMT) characteristics. Herein we report the establishment and characterization of a cell line (TiHoCMglAdcar0906; TiHo-0906) exhibiting EMT-like properties derived from an FMC with anaplastic and malignant spindle cells. Copy-number variations (CNVs) by next-generation sequencing and immunohistochemical characteristics of the cell line and the tumour were compared. The absolute qPCR expression of EMT-related markers HMGA2 and CD44 was determined. The growth, migration, and sensitivity to doxorubicin were assessed. TiHo-0906 CNVs affect several genomic regions harbouring known EMT-, breast cancer-, and hMBCs-associated genes as AKT1, GATA3, CCND2, CDK4, ZEB1, KRAS, HMGA2, ESRP1, MTDH, YWHAZ, and MYC. Most of them were located in amplified regions of feline chromosomes (FCAs) B4 and F2. TiHo-0906 cells displayed an epithelial/mesenchymal phenotype, and high HMGA2 and CD44 expression. Growth and migration remained comparable during subculturing. Low-passaged cells were two-fold more resistant to doxorubicin than high-passaged cells (IC50: 99.97 nM, and 41.22 nM, respectively). The TiHo-0906 cell line was derived from a poorly differentiated cellular subpopulation of the tumour consistently displaying EMT traits. The cell line presents excellent opportunities for studying EMT on FMCs.

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“…7,26,27 In goats, carcinosarcoma has not been reported in any organ, to our knowledge. In other animal species (i.e., mice and rats, 34 dogs, 4,8,15 cats, 31 a rabbit, 36 and a gray squirrel 37 ), most cases are mammary carcinosarcomas (Table 1). Feline carcinosarcomas have also been reported in the uterus, 13,30,32 lung, 14 biliary system, 9 pancreas, 42 and salivary gland.…”

Section: Introductionmentioning

confidence: 99%

Uterine carcinosarcoma (malignant mixed Müllerian tumor): case report in a goat and literature review

2018

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Carcinosarcomas are biphasic malignant tumors composed of 2 distinct neoplastic cell populations, epithelial cells and mesenchymal cells. A 13-y-old, female, mixed-breed goat was presented with a 1-wk history of anuria and lethargy. Transabdominal ultrasonography showed an irregular and heterogeneous structure in the region of the bladder and uterus and changes in the echogenicity of both kidneys. Given the poor prognosis, euthanasia was elected. Autopsy revealed a large mass within the uterine cervix and confirmed the changes in the urinary tract. Histopathology and immunohistochemistry revealed a mixed, anti-cytokeratin AE1/AE3-positive epithelial, and vimentin-positive mesenchymal neoplasm consistent with a homologous carcinosarcoma, also called malignant mixed Müllerian tumor, with areas of double-labeling. We highlight the complexity of the diagnosis of uterine neoplasms in domestic animals and in goats in particular.

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Mammary carcinosarcoma in cat: a case report

Cited by 6 publications

References 5 publications

Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

TiHo-0906: a new feline mammary cancer cell line with molecular, morphological, and immunocytological characteristics of epithelial to mesenchymal transition

Uterine carcinosarcoma (malignant mixed Müllerian tumor): case report in a goat and literature review

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