Adequação de um sistema de hemodiálise em eqüinos

Oliveira, Juliana de; Palhares, Maristela Silveira; Frössler, T.C.; Veado, Júlio César Cambraia; Meniccuci, L.M.; Leme, Fabíola Oliveira Paes; Filho, J.M. Silva

doi:10.1590/s0102-09352008000600008

Cited by 4 publications

References 14 publications

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Renal Replacement Therapy in Healthy Adult Horses

Wong

Witty²,

Alcott

et al. 2013

Veterinary Internal Medicne

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Background: Renal replacement therapy (RRT) has been implemented extensively in people to facilitate recovery from acute renal failure (ARF). RRT has not been explored in horses, but might provide a further treatment option in horses with ARF.Objective: To investigate efficacy and safety of RRT in horses. Animals: Five healthy adult horses. Methods: A prospective study was performed on horses restrained in stocks and intravenously connected to a commercial RRT machine to allow continuous venovenous hemodiafiltration to be performed for 6 hours. The RRT machine was set at the following flow rates: blood flow rate 250 mL/min; dialysate rate 3,000 mL/h; prefilter replacement pump 3,000 mL/h; and postfilter replacement pump rate 2,000 mL/h. Balanced electrolyte solution was used as dialysate and replacement fluid. Heart rate, respiratory rate, body temperature, direct arterial blood pressure, urine output, and various clinicopathologic parameters were measured over the study period.Results: Renal replacement therapy was successfully performed in horses, resulting in a mean creatinine clearance of 0.127 mL/kg/min (68.9 mL/min) and urea reduction ratio of 24%. No adverse effects were detected although a significant decrease in rectal temperature was observed (P .007). A significant increase in serum phosphorus (P .001) and decrease in BUN (P < .001) were also noted. A significant prolongation of prothrombin (P < .01) and partial thromboplastin time (P < .0001) were observed along with a decrease in platelet count (P .04). Conclusions and Clinical Importance: Renal replacement therapy can safely and effectively be used in adult horses.

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Renal Replacement Therapy in Healthy Adult Horses

Wong

Witty²,

Alcott

et al. 2013

Veterinary Internal Medicne

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Use of Renal Replacement Therapy in a Neonatal Foal with Postresuscitation Acute Renal Failure

Wong

Ruby

Eatroff

et al. 2017

Veterinary Internal Medicne

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A newborn foal was presented because it was unresponsive and in cardiopulmonary arrest. Aggressive cardiopulmonary cerebral resuscitation was administered to the foal, which revived the foal; however, acute renal failure developed. Fluid retention and azotemia occurred although the foal was alert and able to suckle. A 6-hour renal replacement therapy session using hemodiafiltration and a continuous renal replacement therapy machine was administered to the foal at 3 days of age which lowered the foal's azotemia and facilitated removal of some of the excess body fluid. Despite therapy, the foal developed pulmonary edema and was euthanized. Although the foal in this case did not survive, this report highlights the possibility of developing postresuscitation complications such as acute renal failure and describes the use of renal replacement therapy using hemodiafiltration as a viable option in neonatal foals with acute kidney injury.

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