Malignant oedema associated with navel infection in a Merino lamb

Morris, W. E.; Uzal, Francisco A.; Paramidani, M.

doi:10.1590/s0102-09352002000400019

Cited by 3 publications

(8 citation statements)

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“…15 This is the result, in part, of impaired neutrophil mobility caused by the action of alpha-toxin of C. perfringens. 15 A similar lack of inflammatory infiltrate has been described in some, but not all, cases of animal gangrene, produced by several clostridial species, 44,50 and it is possible that other clostridial toxins have a similar leukocytoclastic effect to that seen with C. perfringens alpha-toxin, but this has not been proved.…”

Section: Microscopic Changesmentioning

confidence: 90%

“…This, however, may just represent the capacity of this organism to overgrow other histotoxic clostridia when they act together, given that C. septicum grows very quic kly. 11,12,29,44,68 Nevertheless, several cases of gas gangrene in which only C. septicum was detected by fluorescent antibody (FA) testing or immunohistochemistry (IHC) seem to contradict the above statement. 61,62,78,81 FA testing and IHC provide a snapshot of the relative proportion of different clostridial species present in animal tissues and are not affected by the presence of other microorganisms.…”

Section: Clostridium Septicummentioning

confidence: 99%

“…Diffuse hemorrhagic and gelatinous edema and congestion are seen in all tissues around the navel. 44,51 Absence of significant inflammatory response is a characteristic of cases of human C. perfringens-associated gas gangrene. 15 This is the result, in part, of impaired neutrophil mobility caused by the action of alpha-toxin of C. perfringens.…”

Section: Microscopic Changesmentioning

confidence: 99%

“…42 No age predisposition has been described in any animal species, except for cases of omphalophlebitis, which occur in neonatal animals. 44,51…”

Section: Introductionmentioning

confidence: 99%

“…42 No age predisposition has been described in any animal species, except for cases of omphalophlebitis, which occur in neonatal animals. 44,51 Despite the undeniable importance of gas gangrene in mammals, information regarding this disease is dispersed and mostly in the form of case reports. We review and discuss herein the most relevant aspects of gas gangrene in mammals.…”

Section: Introductionmentioning

confidence: 99%

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Gas gangrene in mammals: a review

et al. 2020

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Gas gangrene is a necrotizing infection of subcutaneous tissue and muscle that affects mainly ruminants and horses, but also other domestic and wild mammals. Clostridium chauvoei, C. septicum, C. novyi type A, C. perfringens type A, and C. sordellii are the etiologic agents of this disease, acting singly or in combination. Although a presumptive diagnosis of gas gangrene can be established based on clinical history, clinical signs, and gross and microscopic changes, identification of the clostridia involved is required for confirmatory diagnosis. Gross and microscopic lesions are, however, highly suggestive of the disease. Although the disease has a worldwide distribution and can cause significant economic losses, the literature is limited mostly to case reports. Thus, we have reviewed the current knowledge of gas gangrene in mammals.

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Section: Microscopic Changesmentioning

confidence: 90%

Section: Clostridium Septicummentioning

confidence: 99%

Section: Microscopic Changesmentioning

confidence: 99%

“…42 No age predisposition has been described in any animal species, except for cases of omphalophlebitis, which occur in neonatal animals. 44,51…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gas gangrene in mammals: a review

et al. 2020

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Mionecroses Clostridiais Bovinas

et al. 2010

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RESUMO As mionecroses são enfermidades altamente fatais, representadas pelo carbúnculo sintomático e edema maligno. Com o objetivo de determinar a ocorrência dos diferentes clostrídios envolvidos nas mionecroses em bovinos no Brasil, foi realizado um estudo retrospectivo a partir de 30 casos suspeitos de carbúnculo sintomático e edema maligno. Empregou-se a técnica de estreptavidina biotina peroxidase em tecidos de bovinos fixados em formol e incluídos em parafina de arquivos de patologia de diferentes estados do país. Foram detectados 21 Clostridium chauvoei (70%), cincoClostridium septicum(17%), seguidos de doisC. chauvoeiassociado aoC. septicum (7%), um C. chauvoei mais Clostridium sordellii (3%) e um C. chauvoei mais Clostridium novyi tipo A (3%). Este é o primeiro diagnóstico de C. novyi tipo A no Brasil, e o primeiro relato da ocorrência de C. chauvoei associado à lesão no miocárdio. Os achados da maior ocorrência de C. chauvoei e C. septicum corroboram com estudos anteriores no país. Estes dados sobre a ocorrência dos agentes responsáveis pelas mionecroses em diferentes estados do país são de extrema importância frente às decisões relativas ao controle dessas enfermidades.

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Clostridial Diseases Health Perspective in Farm Animals

2022

Int J Vet Sci

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Malignant oedema associated with navel infection in a Merino lamb

Cited by 3 publications

References 1 publication

Gas gangrene in mammals: a review

Gas gangrene in mammals: a review

Mionecroses Clostridiais Bovinas

Clostridial Diseases Health Perspective in Farm Animals

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