Resultados do tratamento do câncer colorretal (T4) perfurado: análise de 14 pacientes operados

Costa, Sergio Renato Pais; Lupinacci, Renato Arioni

doi:10.1590/s0101-98802008000300001

Cited by 1 publication

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References 16 publications

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“…Symptoms of CRC can be nonspecific or quite fulminant [40]. Emergency situations are most commonly related to the complications of tumour obstruction [41] or tumour perforation [41,42]; these are relatively rare complications, both with a poor prognosis and high risk of recurrence [41]. In a meta-analysis, Jellema et al analysed various symptoms of CRC and concluded that the symptoms most commonly investigated included abdominal pain, rectal bleeding, change in bowel habits, and perianal symptoms.…”

Section: Symptomsmentioning

confidence: 99%

A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital, Northern Portugal

2013

J Gastrointest Dig Syst

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Background: Colorectal cancer (CRC) is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nonetheless, despite being a frequent cancer on which many epidemiological international studies have already been written, Portuguese epidemiological data are scarce and in particular there are very few specific data for Minho Region, which is traditionally recognized as a high incidence area. Aim: Characterize CRC patients treated at Braga Hospital. Methods: Data regarding clinical and preoperative diagnostic examinations, operative reports and histopathological and follow-up data was collected prospectively and stored in two Excel PC databases (colon and rectal cancer) and statistically analysed using the Statistical Package for the Social Sciences, version 19.0 (SPSS Inc., Chicago, Illinois, USA). All comparisons were examined for statistical significance using Pearson's chi-square (χ 2) test and Fisher's exact test (when n<5), with the threshold for significance P values <0.05. Overall survival and Survival free disease were both assessed using the Kaplan-Meier method. Results: The study comprises 672 patients with histological diagnosis of CRC treated in Braga Hospital between 2005 and 2009. It included 62.3% males and 37.7% females and most patients (60.5%) were between 61-80 years old. 65.3% of the cases arose from colon cancer and 34.7% from rectal cancer. We observed that 94.8% of the patients had no previous history of colorectal polyps. 4.1% had a previous personal history of CRC and 7.7% of a different cancer. 9.7% had a positive CRC family history. Most patients (81.3%) were symptomatic at diagnosis, while 18.8% were detected by routine colonoscopies. Colon and rectal cancer from most patients was at IIA stage and IV stage respectively. Follow-up time ranged between 1 and 5 years and, during this period, 26.7% of colon cancer patients and 25.3% of rectal cancer patients died from a colorectal cancer-related cause; also, 14.6% and 19.3% respectively had recurrence, mainly in the liver. Conclusion: This is the first study of a large cohort of CRC patients from the Minho Region in Northern Portugal. The large majority of the 672 cases were diagnosed because symptomatic and at an advanced stage, with a relatively poor prognosis. These findings emphasize the need to start a screening program and diagnose CRC at an early stage, thus increasing cure rates and improving resource management.

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Section: Symptomsmentioning

confidence: 99%

A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital, Northern Portugal

2013

J Gastrointest Dig Syst

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Resultados do tratamento do câncer colorretal (T4) perfurado: análise de 14 pacientes operados

Cited by 1 publication

References 16 publications

A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital, Northern Portugal

A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital, Northern Portugal

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