Resposta completa à terapia neoadjuvante no câncer de reto: apenas sorte ou um resultado previsível?

Pinho, Mauro

doi:10.1590/s0101-98802007000400017

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Isso sugere que a idade influencia o risco das intercorrências inerentes ao ato cirúrgico. 20 Proporcionalmente, o número de fistulas foi maior para os tumores localizados entre o reto médio e baixo (9,09%) quando comparado aos tumores de reto alto (7,79%). Essa alta incidên- Intervalo de confiança (IC), total de pacientes acompanhados em 12 meses (N1), total de pacientes acompanhados em 24 meses(N2), total de pacientes acompanhados em 36 meses (N3), sobrevida em 12 meses (S1), sobrevida geral em 24 meses (S2), sobrevida geral em 36 meses (S3).…”

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Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

Figueiredo¹,

Campos²,

Marcos³

et al. 2014

Revista Médica De Minas Gerais

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RESUMOIntrodução: o câncer colorretal (CCR) é um tumor maligno frequente do aparelho digestivo e, no Brasil, representa a quarta causa de óbito. A sobrevida dos portadores de CCR é influenciada por uma série de variáveis, destacando-se o estadiamento tumoral. A principal modalidade terapêutica com perspectiva de cura é a cirúrgica, tendo como tratamentos adjuvantes a quimioterapia e a radioterapia. Objetivo: avaliar a sobrevida, bem como a taxa de complicações anastomótica dos pacientes com CCR acompanhados entre janeiro de 2007 e janeiro de 2013. Métodos: foi realizado estudo descritivo -série de casos com 171 pacientes. A variável dependente foi o tempo de sobrevida do CCR e as independentes foram faixa etária, sexo, sítio anatômico do tumor, infiltração tumoral e metástase linfonodal. Resultados: a sobrevida global dos pacientes com CCR no pós-operatório em 12, 24 e 36 meses de acompanhamento foi, respectivamente, de: 83,21, 76,56 e 63,47%. Acometimento linfonodal e o grau de infiltração tumoral representaram as variáveis relacionadas a pior prognóstico. Os sítios tumorais mais comuns foram o reto alto e sigmoide (43,75%), seguido do reto médio (18,75%) e reto baixo (18,75%). A deiscência anastomótica foi a complicação pós-operatória mais frequente (6,43%). Conclusão: a infiltração tumoral na parede intestinal e o número de linfonodos positivos influenciaram negativamente o tempo de vida dos pacientes com CCR. A fístula compreendeu a principal complicação anastomótica pós-operatória.Palavras-chave: Cirurgia Colorretal; Taxa de Sobrevida; Prognóstico. ABSTRACT Introduction: Colorectal cancer (CRC) is a common malignant tumor of digestive tract and, in Brazil, is the fourth leading cause of cancer. The survival of patients with CRC isinfluenced by a number of variables, especially the tumor staging. The main therapeutic modality with the prospect of cure is surgical, and as adjuvant chemotherapy and radiotherapy treatments. Objective: Evaluate survival, and the rate of anastomotic complications of patients with CCR followed between January 2007 and January 2013. Methods: This is a descriptive -series of cases study of 171 patients. The dependent variable was the survival time of the CCR and the independent variables were age, gender, anatomic site of the tumor, tumor infiltration and lymph node metastasis. Results: The overall survival of patients with CRC postoperatively in 12, were respectively 83.21%, 76.56% and 63.47%. The presence of lymph node involvement and the degree of tumor infiltration accounted for variables related to worse prognosis. The most common tumor sites were the rectum and sigmoid high (43.75%), followed by the rectum (18.75%) and lower rectum (18.75%). The anastomotic leak was the most common postoperative (6.43%) complication. Conclusion: The tumor infiltration in the intestinal wall and the number of positive nodes influenced negatively on the survival of patients Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

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Section: Discussionunclassified

Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

Figueiredo¹,

Campos²,

Marcos³

et al. 2014

Revista Médica De Minas Gerais

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Neoadjuvant Therapy and Surgery in Rectal Adenocarcinoma: Analysis of Patients with Complete Tumor Remission

Andrade

Leal

Fagundes

et al. 2013

Journal of Coloproctology

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Introduction: the standard treatment for locally advanced extra-peritoneal rectal adenocarcinoma, consists of neoadjuvant treatment with radiotherapy and chemotherapy followed by total mesorectal excision. Objective: evaluate, retrospectively, the patients submitted to neoadjuvant therapy and surgery that presents with total remission of the lesion in the anatomopathological examination. Methods: between 2000 and 2010, 212 patients underwent surgery at the Coloproctology Unit at DMAD at FCM–UNICAMP. They were grouped as: rectosigmoidectomy and colorectal anastomosis (n = 54), rectosigmoidectomy with coloanal anastomosis (n = 41), 114 abdominoperineal resection of the rectum (n = 114) and other (n = 3). Results: thirty (14.2%) patients (mean age 57.6 years; 60% males) showed complete remission of the rectal lesion. 4 (13.3%) had compromised lymph nodes and/or lymphatic invasionAt follow-up (mean 51.9 months), 4 (13.3%) presented with local recurrence (one patient) or distant metastases (two patients had liver metastasis, one had liver and lung, and one had bone metastasis). The mean survival was 86.7%. Conclusion: patients with a complete tumor response show ed an increased survival rate, however, the same patients without evidence of residual tumors could develop local recurrence or distant metastases on a later follow-up.

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Resposta completa à terapia neoadjuvante no câncer de reto: apenas sorte ou um resultado previsível?

Cited by 2 publications

References 21 publications

Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

Neoadjuvant Therapy and Surgery in Rectal Adenocarcinoma: Analysis of Patients with Complete Tumor Remission

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