Estudo retrospectivo do resultado anatomopatológico de 100 polipectomias colonoscópicas realizadas na FMB-UNESP

Hossne, Rogério Saad; Maranhão, Mara Fernandes; Carvalho, Flávia Chiva; Mendes, Fabiana Guandalini

doi:10.1590/s0101-98802007000300001

Cited by 3 publications

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References 9 publications

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“…Polyps were more frequently located in the left colon and the rectum, and these two locations accounted for 71.0% of the observed polyps, which is in accordance with other studies 6,9,17 . On the other hand, Santos et al (2008) located a higher number of polyps in the right colon 7 .…”

Section: Vol 31 Nºsupporting

confidence: 92%

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Correlation between location, size and histologic type of colorectal polyps at the presence of dysplasia and adenocarcinoma

Valarini¹,

Bortoli²,

Wassano³

et al. 2011

J. Coloproctol. (Rio J.)

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Adenocarcinoma represents 96-98% of colorectal neoplasms, and neoplastic polyps (adenomas) are their precursors. The aim of this study is to correlate size, location and histologic type of colorectal polyps at the presence of dysplasia and adenocarcinoma. Methods: Colonoscopies from January/2007 to December/2008 were retrospectively studied, in order to evaluate the characteristics of the polyps. Results and Discussion: Out of the 2,401 analyzed colonoscopies, 583 (24.3%) presented polyps. Due to the lack of histopathologic data, 139 exams were excluded. Mean age of the patients was 58±12 years, and 60% were females. Polyps were prevalent in the left colon (38.5%) and rectum (32.5%). Out of the 850 polyps which were histologically examined, 55.17% were tubular adenomas; 21.88%, hyperplastic; 17.05%, serrated; 5.4%, tubulovillous; and 0.47%, villous. As to polyps £1.0 cm, dysplasia was observed in 16.0% and adenocarcinoma in 1.9%. Those >1.0 cm, 72.0% (p<0.001) presented dysplasia, and 25.3% (p<0.001) presented adenocarcinoma. Polyps in the right and transverse colon were strongly associated with dysplasia (17.8% and 16.7%). Adenocarcinomas were prevalent in the left colon (2.5%) and rectum (2.1%). Conclusion: Polyps were more frequent in the left colon and rectum. The right and transverse colons were strongly correlated with dysplasia. Those of the left colon and rectum were associated with adenocarcinoma. Lesions >1.0 cm were positively related to dysplasia and neoplasm.
O adenocarcinoma representa 96-98% do câncer colorretal, sendo os pólipos neoplásicos (adenomas) seus precursores. O objetivo desse estudo é correlacionar tamanho, localização e tipo histológico de pólipos colorretais com a presença de displasia e adenocarcinoma. Métodos: Estudou-se retrospectivamente colonoscopias realizadas entre janeiro/2007 e dezembro/2008, avaliando-se as características dos pólipos. Resultados e Discussão: Das 2401 colonoscopias analisadas, 583 (24,3%) apresentaram pólipos. Por falta de dados histopatológicos, excluiu-se 139 exames. A média de idade foi 58±12 anos, sendo 60% mulheres. Houve predomínio no cólon esquerdo (38,5%) e reto (32,5%). Quanto ao tamanho, 86,58% eram £1 cm. Dos 850 pólipos analisados histologicamente, 55,17% eram adenomas tubulares, 21,88% hiperplásicos, 17,05% serrilhados, 5,4% tubulovilosos e 0,47% vilosos. Dos pólipos £1,0 cm, 16,0% apresentaram displasia e 1,9% adenocarcinoma; dos >1,0 cm houve displasia em 72,0% (p<0,001) e adenocarcinoma em 25,3% (p<0,001). Pólipos do cólon direito e transverso associaram-se mais à displasia (17,8% e 16,7%, respectivamente). Adenocarcinoma predominou no cólon esquerdo (2,5%) e reto (2,1%). Conclusão: Os pólipos predominaram em cólon esquerdo e reto. Os do cólon direito e transverso correlacionam-se fortemente à displasia, e os do reto e cólon esquerdo ao adenocarcinoma. Lesões maiores que 1,0 cm associaram-se positivamente com a presença de displasia e neoplasia

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Section: Vol 31 Nºsupporting

confidence: 92%

“…The adenoma-carcinoma sequence was fi rst analyzed by Morson and is considered as the main path for colorectal carcinogenesis [16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

Correlation between location, size and histologic type of colorectal polyps at the presence of dysplasia and adenocarcinoma

Valarini¹,

Bortoli²,

Wassano³

et al. 2011

J. Coloproctol. (Rio J.)

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Fecal occult blood test and flexible rectosigmoidoscopy: tools for the screening of colorectal neoplasms in asymptomatic patients

Júca

Assunção

Júnior

2015

Journal of Coloproctology

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Purpose To assess the feasibility and effectiveness of the fecal occult blood test (FOBT) and flexible rectosigmoidoscopy (RSS), as tools used in the CRC screening, in asymptomatic patients, from 50 years of age. Methods The study is transversal and presents a sample of 102 individuals. The FOBT used was the guaiaco, FECA-CULT® method, held at a single time, in feces collected from a complete evacuation. Individuals, who presented the positive FOBT, were sent to colonoscopy complement, although this is not primary variable examined in this study. All subjects underwent to flexible RSS, after bowel preparation, using a solution of sodium phosphate monobasic monohydrate and dibasic sodium phosphate heptahydrate. Results Individuals showed minimum age of 50 years and maximum 82 years, 61.6 years average and standard deviation +8.1. Of the 102 individuals, 42 (41%) belong to the males, whereas 60 (58.8%) female. The FOBT presented 10 positive cases (9.8%) (IC 95%: 4.8–17.3%) and 92 negative cases (90.2%) (IC 95%; 82.7–95.2%). The FOBT was effective at 2.9% and presented false-positive result in 6.9%. The result of the FBOT association with flexible RSS showed that 70% of neoplastic polyps showed no bleeding. Its sensitivity was 30% (IC 95%: 0.00–63.40%), the value of the relative risk was 3.94 (IC 95%: 1.20–12.89) and 5.20 valued odds ratio (IC 95%: −23.15 to 1.21). The specificity was 92.40% (IC 95%: 86.43–98.35%). The flexible RSS detected 15 polyps, among which, after histopathological study, 10 were neoplastic, being 09 adenomatous polyps (60%) and 01 malignity (6.7%) (IC 95%: 0.20–31.90%) and 05 non-neoplastic polyps (33.3%), and 03 inflammatory polyps (20%) (IC 95%: 4.3–48.1%) and 02 hyperplastic polyps (13.3%) (IC 95%: 1.7–40.5%). Neoplastic polyps were present in 60% of individuals over 60 years of age. Among the adenomatous polyps, the adenomatous polyp tubular prevalence is 53.33%. Among the 102 individuals, flexible RSS detected 09 adenomatous polyps (8.82%) and 01 (0.98%) malignity polyp. Conclusion The tools FOBT and flexible RSS presented feasibility and, when associated demonstrated statistical significance in detecting polyps in general and important clinical significance on the detection of adenomatous polyps and colorectal cancer.

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Pathological findings of colorectal polyps analyzed in Curitiba – Brazil

Nisihara

Fudalli

Turra

et al. 2017

Journal of Coloproctology

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Context Colorectal cancer is the third leading cause of death from malignancy in the world and the fourth leading cause in Brazil's ranks. Adenomatous polyps are considered premalignant lesions, and its resection reduces both morbidity and mortality rates. Objectives Investigate the prevalence of premalignant lesions and correlate it with age and gender, as well as with the lesion found profile: location, morphology, histology and grade dysplasia. Methods This was a retrospective, observational and descriptive study. We analyzed and tabulated results of polyps reports sent to Pathology Laboratory in the period ranging from January 1 to December 31, 2013, in Curitiba, Paraná, Brazil. Results We analyzed 4640 reports of colorectal polypectomy, coming from 3089 patients, of whom 97.6% were examined by colonoscopy. Concerning gender, 56.5% were female and 43.5% were male. The mean age was 57.6 years (ranging from 15 to 92 years). The predominant removal areas of polyps were rectum in 26.2% and sigmoid in 24.2% cases. About histological aspects, the most common type – adenoma – was present in 75.1% polyps, of which 74.2% were tubular and 21.7% were serrated. Among the non-adenomatous polyps, hyperplastic prevailed with 88.7% cases. Malignancy was observed in 100 cases (2.15%). Conclusion This study showed higher incidence of colorectal polyps in women, although adenocarcinomas are equally distributed in both sexes. In addition, the average age of patients undergoing colonoscopy is decreasing. Furthermore, 2.15% polyps sent for pathology analysis were found to be malignant.

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Estudo retrospectivo do resultado anatomopatológico de 100 polipectomias colonoscópicas realizadas na FMB-UNESP

Cited by 3 publications

References 9 publications

Correlation between location, size and histologic type of colorectal polyps at the presence of dysplasia and adenocarcinoma

Correlation between location, size and histologic type of colorectal polyps at the presence of dysplasia and adenocarcinoma

Fecal occult blood test and flexible rectosigmoidoscopy: tools for the screening of colorectal neoplasms in asymptomatic patients

Pathological findings of colorectal polyps analyzed in Curitiba – Brazil

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