Efeito da drenagem abdominal na cicatrização de anastomoses colônicas: estudo experimental em ratos

Ortiz, Douglas Falleiros; Lauand, Felipe; Campos, Antonìo; Rocha, José Joaquim Ribeiro da; Féres, Omar

doi:10.1590/s0101-98802007000100009

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…These in turn are important complications in post-operative recovery of the digestive tract as they increase the morbidity and mortality of patients 15 and cause major impact on health care costs. 16 In addition to a social contribution, this study seeks to innovate in academics, since the influence of hepatic ischemia-reperfusion in the healing of duodenal anastomosis is still a subject that is little explored in the literature. Bibliographical searches in the databases of PubMed and SciElo using the keywords ischemia-reperfusion, liver, healing, and duodenum showed only 14 references, none of which were specifically concerned with the present protocol.…”

Section: Introductionmentioning

confidence: 99%

Hepatic ischemia-reperfusion and its effects on duodenal anastomosis healing

Oliveira

Oliveira²,

Almeida³

et al. 2015

J Surg Clin Res

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Background/objetive: The liver ischemia and reperfusion is important for procedures occurring in liver and intestinal trauma injuries that require intestinal resection and anastomosis. The aim of this study was to evaluate the influence of hepatic ischemia/reperfusion in vivo in the healing of duodenal anastomoses. Methods: Wistar rats were randomly selected and allocated into two groups of six animals each: liver ischemia/reperfusion + duodenal anastomosis group and duodenal anastomoses group. Hepatic ischemia was induced for 30 minutes by occlusion of the vessels that supply the median and lateral lobes of the liver, using a microvascular clip. In all rats the duodenum was sectioned and an end-to-end anastomosis was performed. After liver reperfusion, animals were observed for 6 days; the maximum bursting pressure of anastomoses was determined and duodenum samples were taken for histopathological examination. Results: As a result, the maximum bursting pressure of anastomosis in ischemia/reperfusion + duodenal anastomosis group (64.5±5.5mmHg) was significantly lower (p<0.001) than in duodenal anastomosis group rats (89.7±3.4mmHg). The inflammatory tissue response in ischemia/reperfusion + duodenal anastomosis group had scores higher than in duodenal anastomosis group rats (p=0.004). Conclusion: In conclusion, the hepatic ischemia-reperfusion negatively affected the healing process of duodenal anastomoses.

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Section: Introductionmentioning

confidence: 99%