Primeiro registro de Leptogorgia punicea (Milne-Edwards &amp; Haime) (Cnidaria, Octocorallia) para o Estado do Maranhão, Brasil

Pérez, Carlos Daniel

doi:10.1590/s0101-81752005000300046

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“…Gorgonian octocorals are widely distributed marine organisms, and have provided a wide range of new compounds with diverse carbon skeletons and valuable biological activities [ 1 , 2 ]. Leptogorgia punicea (Octocorallia, Gorgonaea) is a reddish purple species, which is found in Brazil, from the coast of Santa Catarina State in the South to the State of Maranhão in the North [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity

et al. 2014

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Five new polyoxygenated marine steroids—punicinols A–E (1–5)—were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel.

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Section: Introductionmentioning

confidence: 99%