Ginkgo biloba e memória: mito ou realidade?

Forlenza, Orestes Vicente

doi:10.1590/s0101-60832003000600004

Cited by 5 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In vitro studies have shown three biological benefits of this substance: prevention of neurotoxicity by amyloid beta, the inhibition of apoptotic pathways, and protection from oxidative damage 19 . Nevertheless, previous randomized trials have revealed that long-term use of Ginkgo Biloba extract did not reduce the risk of AD's progression when compared with a placebo 20,21 .…”

mentioning

confidence: 99%

Trends and disparities in the use of cholinesterase inhibitors to treat Alzheimer’s disease dispensed by the Brazilian public health system – 2008 to 2014: a nation-wide analysis

Moraes

Souza

Lucchetti

et al. 2018

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

In light of the high cost of dementia treatment, there is legislation authorizing free distribution of cholinesterase inhibitors to those suffering from Alzheimer’s disease in Brazil. However, the existence of this free distribution does not guarantee adequate distribution. Objectives The present study aimed to investigate the trends of prescriptions and the coverage of Alzheimer’s disease treatment using cholinesterase inhibitors from public pharmacies dispensing high-cost drugs in Brazil. Methods This was a retrospective study that collected data from the Brazilian public Unified Health System. All cholinesterase inhibitors distributed at no cost to Brazilians during the year 2014, as well as the estimated number and percentages of patients who used these medications, were evaluated and compared to data from the year 2008. Results Our estimates indicated that 9.7% of the population having dementia syndromes used cholinesterase inhibitors, as well as 16.1% of those with Alzheimer’s disease in Brazil. A clear disparity was noted between the use and distribution of cholinesterase inhibitors, depending on the region in which they were found. Over time, an increase in the distribution of cholinesterase inhibitors has been noted. In 2008, that use was 12.0% whereas, in 2014, it was 16.1%, an increase of 34% in six years. Conclusion It was estimated that 16.1% of patients with Alzheimer’s disease in Brazil use cholinesterase inhibitors. These values have increased and, in spite of not being satisfactory, they indicate a potential for improvement. However, there is still a significant disparity among the regions.

show abstract

mentioning

confidence: 99%

Trends and disparities in the use of cholinesterase inhibitors to treat Alzheimer’s disease dispensed by the Brazilian public health system – 2008 to 2014: a nation-wide analysis

Moraes

Souza

Lucchetti

et al. 2018

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…It is constituted by 24% of ginkgo flavone glycosides and 6% of terpenoids (FORLENZA, 2003). Ginkgo biloba has antioxidant mechanism of action (MACARENCO et al, 2001) and antiapoptotic activity (FORLENZA, 2003).…”

Section: Ginkgo Bilobamentioning

confidence: 99%

“…G. biloba possibly potentiates the effect of acetylcholinesterase (CZAP, 2002). Therefore, it is recommended for clinical treatment of Alzheimer's disease (FORLENZA, 2003), cardiovascular diseases, sexual impotence, hepatic fibrosis, memory improvement, cerebral vascular insufficiency, PMS and some kinds of cancer (CZAP, 2002). In patients administered with anticoagulants, there may be a formation of subdural hematoma (ROSENBLATT & MINDEL, 1997).…”

Section: Ginkgo Bilobamentioning

confidence: 99%

Phytotherapy: an introduction to its history, use and application

Ferreira

Moreira

Cária

et al. 2014

Rev. bras. plantas med.

View full text Add to dashboard Cite

There has been a great advance in the pharmacognosy field, which has increased the use of medicinal plants by health professionals and practitioners of folk medicine. This systematic review explored the history and the present day application of phytotherapeutic medicines. We searched the databases Cochrane Library, Embase, Lilacs, PubMed, Scielo and a specialized bibliography. We concluded that there are many therapeutic potentialities in the use of phytotherapeutic medicines and medicinal plants. We also concluded that despite the increasing number of publications in the field each year, there is still a lack of reviews and meta-analyses that could promote a better integration of the knowledge produced. In addition, research about pharmacological interactions and multidisciplinary studies may promote a quicker and safer process from the workbench up to the clinical trials.Keywords: medicine history, herbal medicine, primitive medicine, phytotherapy. RESUMO: Fitoterapia: introdução a sua história, uso e aplicação. Diante do avanço que vem ocorrendo na área da farmacognosia, decorrente do aumento do uso de plantas medicinais na medicina popular e por profissionais da saúde, este trabalho apresenta uma revisão sistemática sobre a história dos fitoterápicos e sobre sua aplicação na atualidade. Foram realizadas buscas nas bases de dados Cochrane Library, Embase, Lilacs, PubMed, Scielo e em bibliografia especializada. Concluiu-se que, apesar da quantidade de estudos publicados crescer a cada ano, há ainda escassez de revisões e meta-análises que promovam melhor integração do conhecimento produzido. Pesquisas contemplando interações farmacológicas e trabalhos multidisciplinares podem acelerar os estudos em bases mais seguras, desde a bancada até os ensaios clínicos.Palavras-chave: história da medicina, ervas medicinais, medicina primitiva, fitoterapia.

show abstract

“…These effects may lead to the development of several diseases, particularly pathologies related to the central nervous system (Alok et al, 2014;Pereira et al, 2014). Because the EGb 761 extract has known antioxidant activity against oxidative stress, it may be effective in both treatments and prophylaxis of chornic degenerative diseases (Diamond et al, 2000;Puppo and Silva, 2008;Jager et al, 2006;Berigan and Page, 2000;Forlenza, 2003;Gauthier and Schlaefke, 2014;Siegel et al, 2014;Cheng et al, 2015;Montes et al, 2015;Solfrizzi and Panza, 2015).…”

Section: Introductionmentioning

confidence: 99%

Ginkgo bilobaL.: Phytochemical components and antioxidant activity

Fermino¹,

Milanez²,

Freitas³

et al. 2015

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Curative effects of Ginkgo biloba L. have been recognized for centuries, dating back to traditional Chinese medicine which used crushed leaves to treat several health problems. Although G. biloba L. has several known and investigated activities, the antioxidant activity of its extract (EGb 761) is particularly relevant because reactive oxygen (ROS) and reactive nitrogen (RNS) species are constantly produced in aerobic organisms. Currently, the exploitation of the antioxidant activity of G. biloba extract Egb 761 has been of particular pharmacological importance because oxidative stress may be harmful to cells and may trigger the development of many disorders. The antioxidant activity of the EGb extract against oxidative stress has been associated with several therapeutic effects and currently, Egb761 is indicated to treat labyrinthitis, headache, memory disturbance, intermittent claudication, dementia, Alzheimer's disease, glaucoma, cardiovascular disorders, cerebral ischemia, increased libido and sexual activity, and psychiatric diseases, such as depression. This study is a review of basic and clinical studies related to antioxidant properties of G. biloba L.

show abstract

Ginkgo biloba e memória: mito ou realidade?

Cited by 5 publications

References 11 publications

Trends and disparities in the use of cholinesterase inhibitors to treat Alzheimer’s disease dispensed by the Brazilian public health system – 2008 to 2014: a nation-wide analysis

Trends and disparities in the use of cholinesterase inhibitors to treat Alzheimer’s disease dispensed by the Brazilian public health system – 2008 to 2014: a nation-wide analysis

Phytotherapy: an introduction to its history, use and application

Ginkgo bilobaL.: Phytochemical components and antioxidant activity

Contact Info

Product

Resources

About