Intoxicação alumínica na DRC

Barreto, Fellype Carvalho; Araújo, Sônia Maria Holanda Almeida

doi:10.1590/s0101-28002011000200016

Cited by 3 publications

(2 citation statements)

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“…Our choice of Al citrate as the vehicle for intoxication was based on studies reporting that this form of Al crosses the gastrointestinal barrier into the blood [ 28 , 29 , 30 , 31 ]. Some authors claim that Al citrate can become soluble Al and a considerable fraction occurs as a neutral complex, capable of easily crossing the membranes and acting as a vehicle that facilitates the absorption of the metal [ 22 , 29 , 30 , 32 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Physical, Chemical, and Immunohistochemical Investigation of the Damage to Salivary Glands in a Model of Intoxication with Aluminium Citrate

Costa

Correa

Júnior

et al. 2014

IJERPH

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Aluminum absorption leads to deposits in several tissues. In this study, we have investigated, to our knowledge for the first time, aluminum deposition in the salivary glands in addition to the resultant cellular changes in the parotid and submandibular salivary glands in a model of chronic intoxication with aluminum citrate in rats. Aluminum deposits were observed in the parotid and submandibular glands. Immunohistochemical evaluation of cytokeratin-18 revealed a decreased expression in the parotid gland with no changes in the submandibular gland. A decreased expression of α-smooth muscle actin was observed in the myoepithelial cells of both glands. The expression of metallothionein I and II (MT-I/II), a group of metal-binding proteins, which are useful indicators for detecting physiological responses to metal exposure, was higher in both glands. In conclusion, we have shown that at a certain time and quantity of dosage, aluminum citrate promotes aluminum deposition in the parotid and submandibular glands, leads to an increased expression of MT-I/II in both the glands, damages the cytoskeleton of the myoepithelial cells in both glands, and damages the cytoskeleton of the acinar/ductal cells of the parotid glands, with the submandibular glands showing resistance to the toxicity of the latter.

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Section: Discussionmentioning

confidence: 99%

Physical, Chemical, and Immunohistochemical Investigation of the Damage to Salivary Glands in a Model of Intoxication with Aluminium Citrate

Costa

Correa

Júnior

et al. 2014

IJERPH

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“…Os teores de Al revelaram que somente 3 das 12 amostras analisadas estavam em discordância com os valores orientadores considerados (Tabela 2). O Al, em concentrações frequentemente presentes em águas de consumo humano (<100 mg/L), mostra baixa toxicidade associada à saúde (Barreto & Araujo 2011).…”

Section: Determinação De Elementos Traçosunclassified

Avaliação de risco à saúde humana associada ao consumo de águas subterrâneas contaminadas em Capitão Gervásio de Oliveira, Estado do Piauí

et al. 2014

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ResumoOs riscos potenciais à saúde humana associados à presença de elementos traços (Ba, B, Ni, Hg, Zn, Mg, Ca, K, P, Na, Cl -, F -) e patógenos fecais foram avaliados em 12 poços de captação de água subterrânea em Capitão Gervásio de Oliveira, Piauí. A metodologia de avaliação de risco à saúde humana proposta pela Agência Americana de Proteção Ambiental foi utilizada para a estimativa numérica dos riscos relacionados à exposição ambiental por Ni, Hg, Zn, B e Ba. A determinação dos coliformes totais e de Escherichia coli foi realizada com o emprego do método Colilert. Todas as concentrações obtidas foram comparadas aos padrões de qualidade recomendados pela legislação brasileira. Os resultados mostraram que os teores da maior parte dos elementos estudados estão abaixo dos valores máximos estipulados pela legislação, com exceção do Hg, Ni e Cl -. Todos os poços estudados mostram águas inapropriadas para o consumo humano quando se considera a contaminação por coliformes. Ainda, a estimativa numérica do risco total à saúde humana indicou que o Ni e o Hg são os metais que mais efetivamente participam do acréscimo de perigo, devendo ser priorizados em ações que decresçam os teores desses metais-traço nas águas consumidas pela população. Palavras-chave: águas subterrâneas, semiárido, saúde humana, risco. AbstractPotential risks on human health associated with trace elements (Ba, B, Ni, Hg, Zn, Ni, Mg, Ca, K, P, Na, Cl -, F -) and fecal pathogens exposure were evaluated in 12 groundwater samples from supply wells at the Capitão Gervásio de Oliveira Municipality, Piauí, Brazil. The methodology for human health risk assessment, established by the American Agency for Environmental Protection, was applied in order to numerically estimate the risks associated with Ni, Hg, Zn, B and Ba exposure. Total coliforms and Escherichia coli were quantified using the Colilert method. The concentrations were compared to the values defined by the Brazilian environmental law. The results revealed that most concentrations were in disagreement with the values defined by the Brazilian legislation, especially Hg, Ni and Cl -. In terms of coliforms pollution, all samples were inappropriate for human consumption. The numerical estimation of the total risks on human health indicated that Ni and Hg are the metals that most effectively increase the hazard, suggesting that actions should be focused on decreasing such levels in drinking water.

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