Prevenção de nefrotoxicidade por contraste com solução de bicarbonato: resultados preliminares e revisão da literatura

Silva, Ricardo Gonçalves da; Silva, Nelson Gonçalves da; Lucchesi, Fabiano; Burdmann, Emmanuel A.

doi:10.1590/s0101-28002010000300012

Cited by 10 publications

(5 citation statements)

References 60 publications

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“…A ocorrência da NIC no homem é variável (SILVA et al, 2010;SANTOS et al, 2011;SEELIGER et al, 2012) e depende da presença de fatores de risco, do tipo e da quantidade do meio de contraste utilizado, da sensibilidade do método empregado para a detecção do acometimento renal (CARRARO-EDUARDO et al, 2008;SANTOS et al, 2011;MESCHI et al, 2006) e do procedimento radiológico realizado (MESCHI et al, 2006).…”

Section: Fatores De Risco Relacionados E Prevalênciaunclassified

“…Embora ainda não haja um consenso universal para a NIC, tem-se adotado frequentemente a definição de aumento relativo de pelo menos 25% ou aumento absoluto de pelo menos 0,5 mg/dL no valor da creatinina sérica basal, em até 48 horas após a administração intravascular de contraste iodado, na ausência de outras causas concomitantes de lesão renal aguda (MORCOS, 1998;MURPHY;BARRETT;PARFREY, 2000;THOMSEN, 2003;KATHOLI, 2006;BARTORELLI;MARENZI, 2008;CARRARO-EDUARDO et al, 2008;KRAMER et al, 2008;MCCULLOUGH, 2008;PUCELIKOVA;DANGAS;MEHRAN, 2008;SILVA et al, 2010). Outros autores definem a NIC por meio da mesma magnitude de redução da função renal, sem uma etiologia alternativa, que pode ocorrer até 72 horas após a administração do MCI (THOMSEN et al, 2014a).…”

Section: Introductionunclassified

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Nefropatia induzida por contraste iodado

Martin¹,

Lorigados²,

Kogika³

et al. 2014

Rev. Acad. Ciênc. Anim.

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Considerando a grande demanda por exames radiológicos que fazem uso de meio de contraste iodado naMedicina Veterinária, especialmente com o advento da tomografia computadorizada, que incrementou consideravelmenteas indicações para o uso dessas substâncias, esta revisão tem por objetivo abordar as principaisquestões relacionadas à nefropatia induzida por contraste. A nefropatia induzida por contraste consisteno declínio da função renal secundariamente à administração intravascular do meio de contraste iodado.O potencial nefrotóxico dos contrastes iodados está diretamente relacionado a suas características físico--químicas e a condições inerentes ao paciente, como a disfunção renal preexistente. Há grande preocupaçãoe ampla informação sobre a nefrotoxicidade dos meios de contraste iodado e a nefropatia induzida porcontraste no homem, no entanto, existem poucos estudos em pequenos animais.

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Section: Fatores De Risco Relacionados E Prevalênciaunclassified

Section: Introductionunclassified

Nefropatia induzida por contraste iodado

Martin¹,

Lorigados²,

Kogika³

et al. 2014

Rev. Acad. Ciênc. Anim.

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“…Contrast-induced nephropathy (CIN) is a type of AKI that occurs after administration of contrast medium and is usually reversible. The pathogenesis of CIN is uncertain but is thought to involve hypoxic injury and generation of free radicals [8]. The contrast medium volume (CMV) is considered to be a major risk factor for AKI [9–14].…”

Section: Introductionmentioning

confidence: 99%

Influence of preoperative serum creatinine level and intraoperative volume of contrast medium on the risk of acute kidney injury after transfemoral transcatheter aortic valve implantation: a retrospective observational study

et al. 2019

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Objective This study aimed to determine if contrast medium volume (CMV) is a risk factor for acute kidney injury (AKI) during transcatheter aortic valve implantation (TAVI) via a transfemoral approach performed without major complications. All TAVI procedures performed at our institution between March 2014 and March 2018 were retrospectively reviewed. AKI was diagnosed using the Acute Kidney Injury Network classification based on the Valve Academic Research Consortium-2 definition. Procedures performed via a transapical approach and those in which circulatory dynamics failed intraoperatively were excluded. Results Eighty-one (96.4%) of 100 patients scheduled for TAVI were enrolled; seven (8.6%) developed AKI and 74 (91.4%) did not. The serum creatinine (SCr) level was significantly higher (p < 0.05) and the estimated glomerular filtration rate was significantly lower in the AKI group (p < 0.05). The CMV was significantly higher in the AKI group (103 ml vs 84 ml, p < 0.05), as was the CMV × SCr/BW value (3.34 vs 1.49, p < 0.01). The area under the curve for CMV × SCr/BW was 0.9228 and the cut-off value was 2.99. The CMV, SCr, and estimated glomerular filtration rate affect the likelihood of AKI after transfemoral TAVI and a CMV × SCr/BW value > 2.99 accurately predicts AKI. Electronic supplementary material The online version of this article (10.1186/s13104-019-4527-2) contains supplementary material, which is available to authorized users.

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“…creatinina basal em 24-48 horas, após a administração intravascular do agente, sem outras causas concomitantes (Morcos 1998, Murphy et al 2000, Thomsen 2003, Katholi 2006, Bartorelli & Marenzi 2008, Carraro-Eduardo et al 2008, Kramer et al 2008, McCullough 2008, Pucelikova et al 2008, Silva et al 2010. Como grande parte dos casos de NIC não é imediatamente evidente, devido ao curso assintomático (Bartorelli & Marenzi 2008), a prevenção constitui a melhor forma de reduzir sua ocorrência (Thomsen 2006, Pucelikova et al 2008.…”

Section: Introductionunclassified

Ultrassonografia modo B e Doppler na avaliação renal de cães submetidos à tomografia computadorizada após administração intravenosa de diferentes meios de contraste iodado

et al. 2017

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Contrast-induced nephropathy (CIN) is an acute disease, secondary to intravascular administration of iodinated contrast media (ICM). The most important mechanisms of this nephropathy are intrarenal prolonged vasoconstriction, medular hypoxia, and ischemia associated with renal tubular damage due to contrast cytotoxicity. Owing to the limited information available in veterinary literature regarding these mechanisms this study aims to compare the renal effects of intravenous administration of two nonionic ICM of different osmolarities in groups of dogs with risk factors for CIN development, by using a B-mode, color, power-and pulsed-wave Doppler ultrasonography, and other laboratory tests, in order to indirectly estimate the nephrotoxic potential of each contrast. The following two groups were established according to the nonionic ICM used: the GIH group [11 dogs administered iohexol (low osmolarity)] and the GID group [seven dogs administered iodixanol (iso-osmolarity)]. Both the groups were administered the same dose (600mgI/kg/IV). The following renal aspects were evaluated before administration of ICM (baseline) and after 1h30min, 24h, and 48h: renal morphometry (length and volume), renal morphology, cortical echogenicity, renal perfusion, and intrarenal vascular resistance (resistive and pulsatility indices); in addition, urinalysis was performed, and urinary gamma-glutamyl transferase:creatinine ratio (GGT:C), urinary protein:creatinine ratio (UPC), and serum creatinine were also measured. Both groups showed similar characteristics with respect to the length, volume, UPC ratio, urinalysis, and serum creatinine levels. No similarity was observed with respect to the pulsatility index (PI) in both the groups and there were no significant differences between baseline and 1h30min, 24h and 48h time points. With respect to the IR and urinary GGT:C, both groups showed no similarity, and significant increases were 1 Recebido em 13 de maio de 2016.Aceito para publicação em 6 de dezembro de 2016. Parte da tese de doutorado do primeiro autor.

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Prevenção de nefrotoxicidade por contraste com solução de bicarbonato: resultados preliminares e revisão da literatura

Cited by 10 publications

References 60 publications

Nefropatia induzida por contraste iodado

Nefropatia induzida por contraste iodado

Influence of preoperative serum creatinine level and intraoperative volume of contrast medium on the risk of acute kidney injury after transfemoral transcatheter aortic valve implantation: a retrospective observational study

Ultrassonografia modo B e Doppler na avaliação renal de cães submetidos à tomografia computadorizada após administração intravenosa de diferentes meios de contraste iodado

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