Effects of defatted amaranth (Amaranthus caudatus L.) snacks on lipid metabolism of patients with moderate hypercholesterolemia

Chávez-Jáuregui, Rosa N.; Santos, Raul D.; Macedo, Alessandra; Chacra, Ana Paula Marte; Martinez, Tânia Leme da Rocha; Arêas, José Alfredo Gomes

doi:10.1590/s0101-20612010000400026

Cited by 20 publications

(6 citation statements)

References 11 publications

(16 reference statements)

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“…there are very few clinical studies available for reference. Chávez-Jáuregui et al [92] evaluated the effects of defatted Amaranth snacks of A. caudatus on plasma lipids in moderately hypercholesterolemic patients. An intake of 50 g of extruded amaranth daily for 60 days did not significantly reduce LDL in these subjects; but there was a significant reduction in HDL (Table 4).…”

Section: Clinical Studiesmentioning

confidence: 99%

Rediscovering the therapeutic potential of Amaranthus species: A review

Peter

Gandhi

2017

Egyptian Journal of Basic and Applied Sciences

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Extracts of Amaranthus have been used to treat several ailments since ancient times. However, Amaranthus spp. has seen a resurgence of interest in recent decades. Literature summarization of in vitro and in vivo studies established that Amaranthus spp. has several protective and curative properties attributed majorly to strong antioxidant activity. This comprehensive review critically analyzes folklore claims of Amaranthus with scientific evidences, delineating its phytochemical based nutrapharmaceutical properties and emphasizes clinical utility of the plant in various chronic diseases, also defining gap areas for future clinical research. Data on 13 edible Amaranthus spp. was acquired via an electronic search including regional scientific journals, theses, books and government reports. These results provide an in-depth analysis of biological effects of major bioactive ingredients present in crude extracts of specific bioparts. However, bioavailability and underlying mechanism of action of constituents isolated from Amaranthus spp. have not been worked out, thus necessitating focused research in this arena.

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Section: Clinical Studiesmentioning

confidence: 99%

Rediscovering the therapeutic potential of Amaranthus species: A review

Peter

Gandhi

2017

Egyptian Journal of Basic and Applied Sciences

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“…A handful of recent studies have documented the effectiveness of consuming the three ancient grains against chronic disease conditions. An early study by Chávez-Jáuregui et al [ 82 ] evaluated the consumption of an extruded amaranth snack on the lipid profile of patients suffering from hypercholesterolemia. Although the study found a reduction in LDL, VLDL, total cholesterol, and triglycerides, none of the parameters were significantly different compared to the placebo group.…”

Section: Clinical Trial Evidence On the Consumption Of Amaranth Quino...mentioning

confidence: 99%

The Role of Amaranth, Quinoa, and Millets for the Development of Healthy, Sustainable Food Products—A Concise Review

Balakrishnan

Goodrich-Schneider

2022

Foods

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The selection of sustainable crops adaptable to the rapidly changing environment, which also cater to the dietary needs of the growing population, is a primary challenge in meeting food security. Grains from ancient crops such as amaranth, quinoa, and millets are positioned to address this challenge and hence have gained dietary predominance among cereals and pseudocereals due to their nutritional value and energy efficiency. From a nutritional perspective, they are recognized for their complete protein, phenolic compounds and flavonoids, prebiotic fibers, and essential micronutrients, including minerals and vitamins. Bioactive peptides from their proteins have shown antihypertensive, antidiabetic, antioxidant, and anticancer properties. The nutritional diversity of these grains makes them a preferred choice over traditional cereals for developing healthy, sustainable food products such as plant-based dairy, vegan meats, and gluten-free products. With growing consumer awareness about sustainability and health, the categories mentioned above are transitioning from ‘emerging’ to ‘mainstream’; however, there is still a significant need to include such healthy grains to fulfill the nutritional gap. This review article emphasizes the health benefits of amaranth, quinoa, and millet grains and discusses the recent research progress in understanding their application in new sustainable food categories. The challenges associated with their incorporation into novels foods and future research directions are also provided.

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“…They are a very good source of healthy lipids, like unsaturated fatty acids, and bioactive compounds like tocopherols, squalene, and biopeptides, between others (Ogrodowska et al., ; Tovar‐Pérez, Lugo‐Radillo, & Aguilera‐Aguirre, ; Velarde‐Salcedo, Bojórquez‐Velázquez, & Barba de la Rosa, ). Different studies show that amaranth biopeptides in addition to presenting cho‐lowering activity, present antithrombotic, antioxidant, and antihypertensive activity, which is why they have a potential application in foods as a functional component (Chávez‐Jáuregui et al., ; Orsini‐Delgado et al., ; Lado, Burini, Rinaldi, Añón, & Tironi, ; Plate & Arêas, ; Quiroga, Aphalo, Nardo, & Añón, ; Sabbione, Rinaldi, Añón, & Scilingo, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of the Incorporation of Amaranth (Amaranthus Mantegazzianus) into Fat‐ and Cholesterol‐Rich Diets for Wistar Rats

Sisti

Scilingo

Añón

2019

Journal of Food Science

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The hypocholesterolemic effect of amaranth was studied in male Wistar rats fed a high‐fat diet that was supplemented with amaranth flour, AF, or isolated protein, AI. Likewise, an in vitro test was carried out, in which the capacity of the AI, AF, the digested isolate, DAI, and the digested amaranth flour, DAF, to displace the cholesterol of the model micelles was evaluated. The in vivo results showed an increase in the excretion of cholesterol through feces (77% for AF7; 23% and 108% for AI30 and AF30, respect control) and a decrease in the content of hepatic cholesterol (98% for AF7; 96% and 53% for AI30 and AF30 respect control); whereas in vitro it was shown that both AF and DAF have greater power to displace cholesterol than the AI and DAI (IC50 0.1, 0.71, 0.2, and 2.1 for AF, DAF, AI, and DAI, respectively). These evidences show that the proteins and fibers of amaranth have an effect on cholesterol metabolism. Practical Application Nowadays, consumers give great importance to the effect that food has on health. The results shown in this work evidence the potential hypocholesterolemic activity presented by amaranth, this is of great importance due to the increase in the incidence of dyslipidemia in the world population and the importance of amaranth as a nonextensive crop of excellent agronomic, nutritional, and bioactive properties suitable for preparation of functional foods.

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Effects of defatted amaranth (Amaranthus caudatus L.) snacks on lipid metabolism of patients with moderate hypercholesterolemia

Cited by 20 publications

References 11 publications

Rediscovering the therapeutic potential of Amaranthus species: A review

Rediscovering the therapeutic potential of Amaranthus species: A review

The Role of Amaranth, Quinoa, and Millets for the Development of Healthy, Sustainable Food Products—A Concise Review

Effect of the Incorporation of Amaranth (Amaranthus Mantegazzianus) into Fat‐ and Cholesterol‐Rich Diets for Wistar Rats

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