Effects of short-term administration of estradiol on reperfusion arrhythmias in rats of different ages

Savergnini, Silvia Q; Reis, Adelina Martha dos; Santos, Robson A; Santos, Paulo Eustáquio de Brito; Ferreira, Anderson J.; Almeida, Alvair P.

doi:10.1590/s0100-879x2012007500169

Cited by 6 publications

(4 citation statements)

References 32 publications

(35 reference statements)

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“…Cyclical arrhythmia patterns have previously been described, 9 with estrogen providing antiarrhythmic effects. 10 , 11 Estrogen-blocking drugs used to treat infertility can theoretically favor arrhythmias in susceptible women in a manner similar to the luteal phase of the menstrual cycle. 12 …”

Section: Discussionmentioning

confidence: 99%

Ablation of a symptomatic spontaneous automatic focus arising from an atriofascicular fiber

Venier

Khairy

Thibault

et al. 2016

HeartRhythm Case Reports

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Section: Discussionmentioning

confidence: 99%

Ablation of a symptomatic spontaneous automatic focus arising from an atriofascicular fiber

Venier

Khairy

Thibault

et al. 2016

HeartRhythm Case Reports

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“…There is also literature suggesting a protective effect of estrogen in experimental models that might be important as a mechanism. Savergnini et al ( 2012 ) studied rats that were sham-operated, ovariectomized and treated with vehicle, or ovariectomized and treated with 17 B-estradiol. Isolated hearts were then subjected to 15 minutes of left coronary artery occlusion and 30 minutes of reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Does sex influence the incidence or severity of reperfusion-induced cardiac arrhythmias?

et al. 2015

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Whether sex affects the acute phase of myocardial ischemia in experimental animal models is currently being debated. Our purpose was to determine if sex influences either the incidence or severity of reperfusion-induced arrhythmias resulting from a brief coronary occlusion. Male and female Sprague–Dawley rats were assigned to the study. Anesthetized animals were subjected to a 5-minute coronary artery occlusion followed by 5 minutes of reperfusion. Mortality differed by sex: 10/27 (37%) of males died due to VT/VF while only 1/16 females (6%) died due to VT/VF (p = 0.033). Quantitative analysis of the electrocardiogram was performed on data acquired from 17 male and 15 female survivors. Analysis showed no other significant differences in ventricular arrhythmias between the two groups. Conclusion: Lethal reperfusion-induced arrhythmias led to a higher mortality in male rats versus female rats. Among survivors there was no difference in any other arrhythmic parameters measured.

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“…One week later, the COvx and MNOvx groups underwent bilateral ovariectomy, as described elsewhere (Moreira et al, 2005;Savergnini et al, 2012), and the experiment lasted for another eight weeks under the same conditions. Body mass and food intake were monitored daily.…”

Section: Methodsmentioning

confidence: 99%

A hydroalcoholic blackberry leaf extract improved glucose tolerance and body composition and attenuated depression-like symptoms in ovariectomized rats.

Mendes

Figueiró²,

Nunes³

et al. 2023

RSD

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Blackberry leaves (Morus nigra) are used in menopause to relieve hot flashes and night sweats and have been investigated in metabolic disorders. However, few studies investigated its effects on metabolic and behavioral disorders when associated with menopause. This study evaluated the effects of a hydroalcoholic extract of M. nigra leaves (MN) on body composition, glucose tolerance, and depression and anxiety-like behaviors in ovariectomized rats. For this purpose, 36 female Wistar rats were divided into groups: C – control; COvx – ovariectomized; MNOvx – ovariectomized and given MN at 400 mg.kg-1 body mass/day. Body composition was assessed by DEXA, glucose tolerance by the oral glucose tolerance test, and depression and anxiety-like behaviors by the forced swimming and elevated plus maze tests, respectively. Food intake and body mass gain were higher for MNOvx, followed by COvx and C (p<0.05). The MNOvx group gained less body fat than COvx (p<0.05) and was more glucose tolerant compared to C and COvx (p<0.05). In the elevated plus maze, COvx and MNOvx remained for less time in the open arms and longer in the closed arms than C (p<0.05). In forced swimming, immobility time was higher for COvx, followed by C and MNOvx (p<0.05). The MN protected ovariectomized rats from body fat gain, improved glucose tolerance, and attenuated depression-like behavior. Phytoestrogens and other bioactive compounds in MN may be involved in these effects.

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Effects of short-term administration of estradiol on reperfusion arrhythmias in rats of different ages

Cited by 6 publications

References 32 publications

Ablation of a symptomatic spontaneous automatic focus arising from an atriofascicular fiber

Ablation of a symptomatic spontaneous automatic focus arising from an atriofascicular fiber

Does sex influence the incidence or severity of reperfusion-induced cardiac arrhythmias?

A hydroalcoholic blackberry leaf extract improved glucose tolerance and body composition and attenuated depression-like symptoms in ovariectomized rats.

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