Reduced hippocampal GABAergic function in Wistar audiogenic rats

Drumond, Luciana E.; Kushmerick, Christopher; Guidine, Patrícia Alves Maia; Doretto, Maria Carolina; Moraes, Márcio Flávio Dutra; Massensini, André Ricardo

doi:10.1590/s0100-879x2011007500118

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…In addition to the behavioral similarities, it is believed that other aspects are shared between the two audiogenic models. Neurochemical and molecular aspects have been investigated and suggest that GASH/Sal presents abnormalities in the GABAergic neurotransmission (15) as already proposed for the WAR model (16,17). Furthermore, López-López et al (18) revealed common molecular alterations, such as the overexpression of the Egr1, Egr2, and Egr3 genes in the IC of both models.…”

Section: Introductionmentioning

confidence: 79%

Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal

et al. 2020

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Section: Introductionmentioning

confidence: 79%

Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal

et al. 2020

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“…In addition, WARs and other audiogenic strains show abnormalities in neurochemical systems and anatomical structures that have also been suggested to modulate emotional, social, motivational, and mnemonic aspects of behavior. The WARs show evidence for altered cholinergic and GABAergic systems when compared with Wistar controls [19,20].…”

Section: Introductionmentioning

confidence: 94%

Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

Castro

Medeiros

Guarnieri

et al. 2017

Epilepsy & Behavior

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Accumulating evidence from different animal models has contributed to the understanding of the bidirectional comorbidity associations between the epileptic condition and behavioral abnormalities. A strain of animals inbred to enhance seizure predisposition to high-intensity sound stimulation, the Wistar audiogenic rat (WAR), underwent several behavioral tests: forced swim test (FST), open-field test (OFT), sucrose preference test (SPT), elevated plus maze (EPM), social preference (SP), marble burying test (MBT), inhibitory avoidance (IAT), and two-way active avoidance (TWAA). The choice of tests aimed to investigate the correlation between underlying circuits believed to be participating in both WAR's innate susceptibility to sound-triggered seizures and the neurobiological substrates associated with test performance. Comparing WAR with its Wistar counterpart (i.e., resistant to audiogenic seizures) showed that WARs present behavioral despair traits (e.g., increased FST immobility) but no evidence of anhedonic behavior (e.g., increased sucrose consumption in SPT) or social impairment (e.g., no difference regarding juvenile exploration in SP). In addition, tests suggested that WARs are unable to properly evaluate degrees of aversiveness (e.g., performance on OFT, EPM, MBT, IAT, and TWAA). The particularities of the WAR model opens new venues to further untangle the neurobiology underlying the co-morbidity of behavioral disorders and epilepsy. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".

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“…There are grounds for considering that the source of genetically determined increases in sound sensitivity in most cases consists of the auditory nuclei, while the inferior and then the superior colliculi, medial geniculate body, and amygdala play an important role in maintaining this state [8,17,19,26]. In addition, audiogenic rats showed some functional insufficiency of the GABAergic inhibitory system and some increase in the excitability of hippocampal neurons [15,35].…”

Section: Discussionmentioning

confidence: 99%

Effects of Ionotropic Glutamate Receptor Blockers on Pentylenetetrazole-Induced Seizures in Krushinskii–Molodkina Rats

Kim

Zaitsev

Lavrent’eva

et al. 2014

Neurosci Behav Physi

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The common final stage in convulsive syndrome is an excess of rhythmic activity of motor cortex neurons. The initial points in the development of this stage can be located in different brain structures and can be the targets of different etiological factors. The pathways of the pathogenesis of convulsions from target to appearance of intense electrical spike activity in the motor centers are also various. The main approaches to studying the pathogenesis of epilepsy and identification of the molecular mechanisms underlying it and seeking anticonvulsive agents include experimental models of convulsive states [20].The clear multiplicity in the nosological forms of human epilepsy dictates the need to use and compare different models of convulsive states induced in animals. The role of convulsants, i.e., actions provoking transient (convulsive seizures) or prolonged recurrent convulsive states, can be played by many chemical agents with different mechanisms of action, as well as electrical stimulation. Depending on the intensity and duration of action, these produce increased convulsive readiness and/or active convulsive foci detected by neurological observations of experimental animals, Krushinskii-Molodkina (KM) rats have a genetic predisposition to increased audiogenic convulsive readiness and respond to sound signals with clonic-tonic convulsive seizures reminiscent of epileptic attacks in humans. The aims of the present work were to compare the neurological manifestations of the convulsant pentylenetetrazol (corazol) in Wistar and KM rats, i.e., to identify the contribution of genetically caused audiogenic convulsive readiness, and to assess the abilities of the NMDA receptor blockers memantine and 1-phenylcyclohexylamine (IEM-1921) to prevent the actions of pentylenetetrazol in KM rats. Convulsive reactions to administration of pentylenetetrazol were significantly stronger in KM rats than in Wistar rats, and deaths in KM rats were 2.1 times more frequent. Both blockers demonstrated the ability to reduce convulsive reactions to administration of pentylenetetrazol; the prophylactic action of IEM-1921 was more marked. IEM-1921 decreased the mean intensity of convulsive seizures by 2 points on a 5-point scale, while the total duration of generalized seizures decreased 41-fold. IEM-1921 completely prevented deaths among the animals, while memantine produce no more than a tendency to a decrease in lethality (68% in controls, 50% after administration of memantine). The results obtained here provide evidence that NMDA glutamate receptors play an important role in the molecular mechanisms of convulsive syndromes of different etiologies.

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Reduced hippocampal GABAergic function in Wistar audiogenic rats

Cited by 9 publications

References 35 publications

Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal

Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal

Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

Effects of Ionotropic Glutamate Receptor Blockers on Pentylenetetrazole-Induced Seizures in Krushinskii–Molodkina Rats

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