Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine transporter/ERK signaling pathway

Zhang, Leiyi; Zhou, Yueying; Chen, Fei; Wang, Bing; Li, Jing; Deng, Youwen; Liu, Weidong; Wang, Zhengguang; Li, Yawei; Li, Dong-Zhe; Lv, Guohua; Yin, Bin

doi:10.1590/s0100-879x2011007500078

Cited by 25 publications

(14 citation statements)

References 38 publications

(30 reference statements)

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“…Accumulation of glycogen vacuoles in the liver was previously observed in fish fed high amounts of crystal amino acids which could not be entirely utilized toward protein synthesis and were metabolized by gluconeogenesis and stored in the liver as glycogen (Dabrowski and Guderley, 2002;Ostaszewska et al, 2008;Walton et al, 1982). Many factors influence the digestibility and bioavailability of amino acids and other nutrients (Rønnestad et al, 2003); it is possible that taurine plays a role in this domain and facilitates amino acid metabolism through signaling properties (Baek et al, 2012;Zhang et al, 2011). The development of hepatic vacuoles and glycogen accumulation is evidence of a marked metabolic disruption, likely to affect the whole organism; this clearly warrants further research.…”

Section: Impact On the Liver And General Metabolismmentioning

confidence: 99%

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

et al. 2016

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Section: Impact On the Liver And General Metabolismmentioning

confidence: 99%

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

et al. 2016

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“…It could also stimulate cell proliferation in neural stem/progenitor cells, neural progenitor cells and osteoblast cells (Jeon et al 2007;Hernandez-Benitez et al 2010. Taurine inhibited serum deprivationinduced cell apoptosis via the taurine transporter and extracellular signal-regulated kinase (ERK) signaling pathway, and increased cell proliferation by ERK 1/2 activation (Jeon et al 2007;Zhang et al 2011). It also promoted osteoclastogenesis through the taurine transporter that was downregulated by calcium blockers in osteoblast cells (Kang 2009;Yuan et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…; Zhang et al 2011). In addition, taurine could obviously promote GAG deposition in cultured chondrocytes as shown by biochemical assay (Fig.…”

mentioning

confidence: 99%

Chondroprotective Effects of Taurine in Primary Cultures of Human Articular Chondrocytes

Liu

et al. 2015

Tohoku J. Exp. Med.

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Articular cartilage is characterized by the lack of blood vessels and has a poor self-healing potential. Limited cell numbers and dedifferentiation of chondrocytes when expanded in vitro are the major obstacles of autologous chondrocyte implantation. Autologous chondrocyte implantation is a cell-based treatment that can be used as a second-line measure to regenerate chondral or osteochondral defects in younger, active patients. There is an urgent need to find an effective chondrogenic protection agent alleviating or inhibiting chondrocyte dedifferentiation. In this study, we explored the effect of taurine (2-aminoethane sulfonic acid) on proliferation and phenotype maintenance of human articular chondrocytes by analyzing the cell proliferation, morphology, viability, and expression of cartilage specific mRNAs and proteins. Primary chondrocytes were isolated from human articular cartilage tissues. Results showed that taurine effectively promoted chondrocyte growth and enhanced accumulation of glycosaminoglycans and collagens in the conditioned media of chondrocytes. Moreover, taurine exposure caused significant increases in the relative expression levels of mRNAs for cartilage specific markers, including aggrecan, collagen type II and SOX9. Aggrecan is a cartilage-specific proteoglycan, and SOX9 is a chondrogenic transcription factor. In contrast, the mRNA expression of collagen type I, a marker for chondrocyte dedifferentiation, was significantly decreased in cells treated with taurine, indicating that taurine inhibits the chondrocyte dedifferentiation. This study reveals that taurine is effective in proliferation promotion and phenotype maintenance of chondrocytes. Thus, taurine may be a useful pro-chondrogenic agent for autologous chondrocyte implantation in the treatment of cartilage repair.

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“…Genetic defects affecting the creatine transporter CreaT result in mental retardation with seizures [65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82]. Defective cellular taurine uptake by TauT fosters apoptosis [83,84,85,86,87,88,89,90,91]. …”

Section: Discussionmentioning

confidence: 99%

Upregulation of Na⁺,Cl^--Coupled Betaine/ γ-Amino-Butyric Acid Transporter BGT1 by Tau Tubulin Kinase 2

Almilaji

Muñoz

Hosseinzadeh

et al. 2013

Cell Physiol Biochem

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Background/Aims: The serine/threonine kinase Tau-tubulin-kinase 2 (TTBK2) is expressed in various tissues including kidney, liver and brain. Loss of function mutations of TTBK2 lead to autosomal dominant spinocerebellar ataxia type 11 (SCA11). Cell survival is fostered by cellular accumulation of organic osmolytes. Carriers accomplishing cellular accumulation of organic osmolytes include the Na⁺, Cl^--coupled betaine/γ-amino-butyric acid transporter BGT1. The present study explored whether TTBK2 participates in the regulation of BGT1 activity. Methods: Electrogenic transport of GABA was determined in Xenopus oocytes expressing BGT1 with or without wild-type TTBK2, truncated TTBK2[1-450] or kinase inactive mutants TTBK2- KD and TTBK2[1-450]-KD. Results: Coexpression of wild-type TTBK2, but not of TTBK2[1-450], TTBK2-KD or TTBK2[1-450]-KD, increased electrogenic GABA transport. Wildtype TTBK2 increased the maximal transport rate without significantly modifying affinity of the carrier. Coexpression of wild-type TTBK2 significantly delayed the decline of transport following inhibition of carrier insertion with brefeldin A, indicating that wild-type TTBK2 increased carrier stability in the cell membrane. Conclusion: Tau-tubulin-kinase 2 TTBK2 is a powerful stimulator of the osmolyte and GABA transporter BGT1.

show abstract

Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine transporter/ERK signaling pathway

Cited by 25 publications

References 38 publications

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

Chondroprotective Effects of Taurine in Primary Cultures of Human Articular Chondrocytes

Upregulation of Na⁺,Cl^--Coupled Betaine/ γ-Amino-Butyric Acid Transporter BGT1 by Tau Tubulin Kinase 2

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Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine transporter/ERK signaling pathway

Cited by 25 publications

References 38 publications

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

Chondroprotective Effects of Taurine in Primary Cultures of Human Articular Chondrocytes

Upregulation of Na+,Cl--Coupled Betaine/ γ-Amino-Butyric Acid Transporter BGT1 by Tau Tubulin Kinase 2

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Upregulation of Na⁺,Cl^--Coupled Betaine/ γ-Amino-Butyric Acid Transporter BGT1 by Tau Tubulin Kinase 2