2011
DOI: 10.1590/s0100-879x2011007500060
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An HPLC-UV method for the measurement of permeability of marker drugs in the Caco-2 cell assay

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Cited by 23 publications
(14 citation statements)
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“…The P app values across the Caco-2 cell monolayer for A to B of GG, atenolol, furosemide, carbamazepine, and verapamil were determined. In this study, the P app for QC compounds as well as the permeability rank were comparable with the literature values [10,[15][16][17]. The permeability rank of the test and QC compounds were done according to "low", if P app < 2.5 × 10 − 6 cm/sec, and "high", if P app ≥ 2.50 × 10 − 6 cm/sec.…”
mentioning
confidence: 55%
“…The P app values across the Caco-2 cell monolayer for A to B of GG, atenolol, furosemide, carbamazepine, and verapamil were determined. In this study, the P app for QC compounds as well as the permeability rank were comparable with the literature values [10,[15][16][17]. The permeability rank of the test and QC compounds were done according to "low", if P app < 2.5 × 10 − 6 cm/sec, and "high", if P app ≥ 2.50 × 10 − 6 cm/sec.…”
mentioning
confidence: 55%
“…Thereafter, samples (100 μL) were taken out from the receiver side at 0.5, 1.0, 1.5, 2.0 and 3.0 h, and the equivalent volume of fresh transport medium was supplemented. Finally, all the samples were analyzed by HPLC system [26,27], and free riboflavin laurate was measured by the method developed in our lab.…”
Section: Methodsmentioning
confidence: 99%
“…Propranolol is a non-substrate of P-gp and was used as a marker for passive, transcellular transport [22]. Propranolol alone data were not acquired for this particular study as propranolol is commonly used as marker for the transcellular transport known not to be influenced by P-gp and R123.…”
Section: Caco-2 Transport Studiesmentioning
confidence: 99%