Essential regulatory elements for NHE3 gene transcription in renal proximal tubule cells

Neri, Elida Adalgisa; Bezerra, Camila Nogueira Alves; Rebouças, Nancy Amaral

doi:10.1590/s0100-879x2011007500054

Cited by 6 publications

(3 citation statements)

References 25 publications

(14 reference statements)

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“…Little is known about the transcriptional regulation of the genes encoding for NHE3 and NaPi2a (SLC9A3 and SLC34A1, respectively). However, CREB binding sites have been identified in the promoter region of each of these two genes [ 118 , 119 ]. Thus, these genes are indeed candidates for being subject to transcriptional control by CRTCs and SIK1.…”

Section: Discussionmentioning

confidence: 99%

Gene Level Regulation of Na,K-ATPase in the Renal Proximal Tubule Is Controlled by Two Independent but Interacting Regulatory Mechanisms Involving Salt Inducible Kinase 1 and CREB-Regulated Transcriptional Coactivators

Taub

2018

IJMS

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For many years, studies concerning the regulation of Na,K-ATPase were restricted to acute regulatory mechanisms, which affected the phosphorylation of Na,K-ATPase, and thus its retention on the plasma membrane. However, in recent years, this focus has changed. Na,K-ATPase has been established as a signal transducer, which becomes part of a signaling complex as a consequence of ouabain binding. Na,K-ATPase within this signaling complex is localized in caveolae, where Na,K-ATPase has also been observed to regulate Inositol 1,4,5-Trisphosphate Receptor (IP3R)-mediated calcium release. This latter association has been implicated as playing a role in signaling by G Protein Coupled Receptors (GPCRs). Here, the consequences of signaling by renal effectors that act via such GPCRs are reviewed, including their regulatory effects on Na,K-ATPase gene expression in the renal proximal tubule (RPT). Two major types of gene regulation entail signaling by Salt Inducible Kinase 1 (SIK1). On one hand, SIK1 acts so as to block signaling via cAMP Response Element (CRE) Binding Protein (CREB) Regulated Transcriptional Coactivators (CRTCs) and on the other hand, SIK1 acts so as to stimulate signaling via the Myocyte Enhancer Factor 2 (MEF2)/nuclear factor of activated T cell (NFAT) regulated genes. Ultimate consequences of these pathways include regulatory effects which alter the rate of transcription of the Na,K-ATPase β1 subunit gene atp1b1 by CREB, as well as by MEF2/NFAT.

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Section: Discussionmentioning

confidence: 99%

Gene Level Regulation of Na,K-ATPase in the Renal Proximal Tubule Is Controlled by Two Independent but Interacting Regulatory Mechanisms Involving Salt Inducible Kinase 1 and CREB-Regulated Transcriptional Coactivators

Taub

2018

IJMS

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“…These degraded ECM fragments could function as 'Matrikines,' upregulating Erk1/2, JNK, and NFκB signaling 32,58 . NHE3 and SCNN1A expression are regulated by these pathways 59,60 . Therefore, collagen degraded by MMPs could function as a 'Matrikines,' which could involve increased expression of NHE3 and SCNN1A.…”

Section: Discussionmentioning

confidence: 99%

The Elderly’s Organs are Ready for Functional Rejuvenation

Kim

Lee

Park

et al. 2022

Preprint

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The biological process of aging is thought to result in part from accumulation of senescent cells in organs. However, the present study identified that the numbers of full-senescent cells were not increased in normal elderly tissue. Instead, fibroblasts and smooth muscle cells that were neither proliferative nor fully senescent were prevalent in tissues of the elderly, which we termed “mid-old” cells. Upregulation of pro-inflammatory genes (IL1β, SAA1) and downregulation of anti-inflammatory genes (SLIT2, CXCL12) were detected in mid-old cells. In the stroma, SAA1 promotes development of the inflammatory microenvironment via upregulation of MMP9, which decreases the stability of epithelial cells present on the basement membrane, decreasing epithelial cell function. Strikingly, the microenvironmental change and the functional decline of mid-old cells could be rejuvenated by a young cell-originated protein, SLIT2. We provided the functional reverse of mid-old cells rather than elimination of senescent cells as a new concept about rejuvenation.

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“…Primeiramente, durante minha iniciação científica, foi analisada a atividade promotora do maior fragmento disponível no laboratório (-2094/+55) e do fragmento correspondente às posições de -152 a +55, que em experimentos realizados previamente pelo laboratório da Profa. Nancy, mostrou-se que era o mais ativo dentre os fragmentos disponíveis 80…”

Section: Efeitos Da Acidose Metabólica Sobre O Promotor Do Gene Do Nhe3unclassified

Análise comparativa dos efeitos da acidose metabólica e respiratória sobre a isoforma 3 do trocador sódio hidrogênio (NHE3).

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Essential regulatory elements for NHE3 gene transcription in renal proximal tubule cells

Cited by 6 publications

References 25 publications

Gene Level Regulation of Na,K-ATPase in the Renal Proximal Tubule Is Controlled by Two Independent but Interacting Regulatory Mechanisms Involving Salt Inducible Kinase 1 and CREB-Regulated Transcriptional Coactivators

Gene Level Regulation of Na,K-ATPase in the Renal Proximal Tubule Is Controlled by Two Independent but Interacting Regulatory Mechanisms Involving Salt Inducible Kinase 1 and CREB-Regulated Transcriptional Coactivators

The Elderly’s Organs are Ready for Functional Rejuvenation

Análise comparativa dos efeitos da acidose metabólica e respiratória sobre a isoforma 3 do trocador sódio hidrogênio (NHE3).

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