Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats

Soares, Everton Rocha; Lima, Wanderson Geraldo de; Machado, R.P.; Carneiro, Cláudia Martins; Silva, M.E.; Rodrigues, M.; Castro, U.G. De; Santos, Robson Augusto Souza; Campagnole‐Santos, Maria José; Alzamora, Andréia Carvalho

doi:10.1590/s0100-879x2011007500049

Cited by 23 publications

(32 citation statements)

References 36 publications

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“…The data from the present study are consistent with our prior study and with other studies [27,28] and show that the rats submitted to the FAT diet for 13 weeks and kept SED, also showed lower physical fitness due to high blood concentrations of lactate [13,30] and total cholesterol, glucose, insulin and ALT; and increases in the body mass and retroperitoneal fat. Additionally, the FAT-SED rats showed micro-and macro-steatosis, reduction of CAT activity, increased concentrations of TBARS, GSSG, protein carbonyl and the GSH/GSSG ratio, and reduced gene expression of IRS-1 and AKT-2 in the liver, in addition to increases in MAP and HR.…”

Section: Discussionsupporting

confidence: 93%

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Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet

et al. 2017

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(2017) Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet, Redox Report, 22:6, 515-523, DOI: 10.1080/13510002.2017 Oxidative stress, physical inactivity and high-fat (FAT) diets are associated with hepatic disorders such as metabolic syndrome (MS). The therapeutic effects of physical training (PT) were evaluated in rats with MS induced by FAT diet for 13 weeks, on oxidative stress and insulin signaling in the liver, during the last 6 weeks. FAT-sedentary (SED) rats increased body mass, retroperitoneal fat, mean arterial pressure (MAP) and heart rate (HR), and total cholesterol, serum alanine aminotransferase, glucose and insulin. Livers of FAT-SED rats increased superoxide dismutase activity, thiobarbituric acid-reactive substances, protein carbonyl and oxidized glutathione (GSSG); and decreased catalase activity, reduced glutathione/GSSG ratio, and the mRNA expression of insulin receptor substrate 1 (IRS-1) and serine/threonine kinase 2. FAT-PT rats improved in fitness and reduced their body mass, retroperitoneal fat, and glucose, insulin, total cholesterol, MAP and HR; and their livers increased superoxide dismutase and catalase activities, the reduced glutathione/GSSG ratio and the expression of peroxisome proliferator-activated receptor gamma and insulin receptor compared to FAT-SED rats. These findings indicated adaptive responses to PT by restoring the oxidative balance and insulin signaling in the liver and certain biometric and biochemical parameters as well as MAP in MS rats.

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Section: Discussionsupporting

confidence: 93%

“…However, different levels of PT intensity (high, moderate or low) induce different adaptations in the body. In contrast to high-intensity PT, moderate-to-low-intensity training leads to increased antioxidant defenses and has a preventive and therapeutic role in major diseases associated with oxidative stress [3,[12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet

et al. 2017

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“…The main mechanism underlying the reduction in blood pressure elicited by coconut oil can be attributed to its antioxidant activity, which will be discussed in detail below. In addition, several studies have demonstrated the effect of exercise training in reducing blood pressure in hypertensive rats (Horta et al 2005;Soares et al 2011;Abate et al 2012;Rossi et al 2013;Mizuno et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats

Alves

Porpino

Monteiro

et al. 2015

Appl. Physiol. Nutr. Metab.

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Abstract:The hypothesis that oral supplementation with virgin coconut oil (Cocos nucifera L.) and exercise training would improve impaired baroreflex sensitivity (BRS) and reduce oxidative stress in spontaneously hypertensive rats (SHR) was tested. Adult male SHR and Wistar Kyoto rats (WKY) were divided into 5 groups: WKY + saline (n = 8); SHR + saline (n = 8); SHR + coconut oil (2 mL·day −1 , n = 8); SHR + trained (n = 8); and SHR + trained + coconut oil (n = 8). Mean arterial pressure (MAP) was recorded and BRS was tested using phenylephrine (8 g/kg, intravenous) and sodium nitroprusside (25 g·kg −1 , intravenous). Oxidative stress was measured using dihydroethidium in heart and aorta. SHR + saline, SHR + coconut oil, and SHR + trained group showed higher MAP compared with WKY + saline (175 ± 6, 148 ± 6, 147 ± 7 vs. 113 ± 2 mm Hg; p < 0.05). SHR + coconut oil, SHR + trained group, and SHR + trained + coconut oil groups presented lower MAP compared with SHR + saline group (148 ± 6, 147 ± 7, 134 ± 8 vs. 175 ± 6 mm Hg; p < 0.05). Coconut oil combined with exercise training improved BRS in SHR compared with SHR + saline group (−2.47 ± 0.3 vs. −1.39 ± 0.09 beats·min −1 ·mm Hg −1 ; p < 0.05). SHR + saline group showed higher superoxide levels when compared with WKY + saline (774 ± 31 vs. 634 ± 19 arbitrary units (AU), respectively; p < 0.05). SHR + trained + coconut oil group presented reduced oxidative stress compared with SHR + saline in heart (622 ± 16 vs. 774 ± 31 AU, p < 0.05). In aorta, coconut oil reduced oxidative stress in SHR compared with SHR + saline group (454 ± 33 vs. 689 ± 29 AU, p < 0.05). Oral supplementation with coconut oil combined with exercise training improved impaired BRS and reduced oxidative stress in SHR.Key words: virgin coconut oil, swimming, hypertension, baroreflex, antioxidant. Résumé :On vérifie l'hypothèse selon laquelle la supplémentation per os en huile de coco (Cocos nucifera L.) vierge et l'entraînement physique atténuent le dérèglement de la sensibilité du baroréflexe (« BRS ») et diminuent le stress oxydatif chez des rats spontanément hypertendus (« SHR »). On répartit des rats mâles adultes SHR et Wistar Kyoto (« WKY ») en cinq groupes : WKY + saline (n = 8); SHR + saline (n = 8); SHR + huile de coco (2 mL·jour −1 , n = 8); SHR + entraînés (n = 8) et SHR + entraînés + huile de coco (n = 8). On enregistre la pression artérielle moyenne (« MAP ») et on évalue la BRS par l'administration de phényléphrine (8 g·kg −1 , intraveineux) et de nitroprussiate de sodium (25 g·kg −1 , intraveineux). On évalue le stress oxydatif par l'administration de dihydroéthidium dans le coeur et l'aorte. Les groupes SHR + saline, SHR + huile de coco et SHR + entraînés présentent une MAP plus élevée comparativement au groupe WKY + saline (175 ± 6, 148 ± 6, 147 ± 7 vs 113 ± 2 mm Hg, p < 0,05). Les groupes SHR + huile de coco, SHR + entraînés, SHR + entraînés + huile de coco présentent une MAP plus basse comparativement au groupe SHR + saline (148 ± 6, 147 ± 7, 134 ± 8 vs 175 ± 6 mm Hg, p < 0,05). L'hui...

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“…Increased adenosine production may be an important contributor to the enhanced coronary blood flow and angiogenesis that were observed in the exercise-trained rats; collectively, these results suggest improved myocardial perfusion. Soares et al [51] examined the effect of exercise training without or with a 3% workload on different cardiac and renal parameters in renovascular hypertensive (2K1C) male Fisher rats weighing 150-200 g. Morphometric evaluation showed concentric left ventricle hypertrophy in sedentary rats. Unloaded exercise prevented concentric cardiac hypertrophy, increased cardiomyocyte diameter and decreased cardiac vasculature thickness.…”

Section: Kk and Rocha E Silva M -Cardiology In Brazilian Scientific Joumentioning

confidence: 99%

Cardiology in Brazilian scientific journals: an overview

Patel

Silva

2012

Rev Bras Cir Cardiovasc

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Cardiology has been and is a very significant fraction of the Brazilian contribution to science. In older days, the most significant part of this work was directed to foreign periodicals, but the quasi-simultaneous emergence of SciELO and PUBMED has ordained a redirection of much of this work to Brazilian periodicals. We here survey some of this more recent contribution for the benefit of readers of Revista Brasileira de Cirurgia Cardiovascular. This is offered as an update. Articles on the general themes of Cardiology and Pneumology published by four ISI Indexed Brazilian journals not specializing in cardiology are re-visited, after a search through 10 journals. ResumoA Cardiologia foi, e continua sendo, responsável por uma fracção muito significativa da contribuição brasileira para a ciência. No passado, os trabalhos mais importantes eram direcionados para periódicos estrangeiros, mas o surgimento quase simultâneo do SciELO e PUBMED facilitou um redirecionamento de grande parte desses trabalhos a periódicos brasileiros. Neste artigo, examinamos algumas das contribuições mais recentes em benefício aos leitores da Revista Brasileira de Cirurgia Cardiovascular. Esta discussão é oferecida como uma atualização. Artigos sobre os temas gerais da cardiologia e pneumologia publicados por quatro revistas brasileiras indexadas no ISI -não especializadas em cardiologia -são revistos.RBCCV

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Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats

Cited by 23 publications

References 36 publications

Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet

Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats

Cardiology in Brazilian scientific journals: an overview

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